Posted on 08/25/2025 1:05:38 AM PDT by Morgana
Cutting-edge technology could one day transform treatment for Down syndrome, as researchers have successfully deleted an extra chromosome in lab-grown cells.
Down syndrome - which occurs when a person has three copies of chromosome 21 instead of two - alters brain development and can cause intellectual disability, learning difficulties and other health challenges.
It affects about one in 700 births in the US, with an estimated 250,000 people living with the condition.
Scientists from Mie University in Japan have used CRISPR-Cas9, a DNA-editing tool often described as 'molecular scissors,' to cut away the surplus chromosome in cells.
Their system was able to distinguish the duplicated chromosome from the two original parental copies, ensuring the cell kept one from each parent rather than two identical versions.
Those corrected cells began showing more typical patterns of gene activity and cellular behavior, especially in pathways linked to brain development.
While the results are a striking proof of concept, experts stress that this research is still far from becoming a therapy.
'Removing an extra chromosome from a single cell has been possible for more than a decade, and CRISPR has made the process more precise,' Dr Roger Reeves of Johns Hopkins University School of Medicine told the Daily Mail.
(Excerpt) Read more at dailymail.co.uk ...
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I remember discussing this with a scientist way back in 1970.
bkmk
Timing of required surgery would be almost impossible.
Without early detection I don’t see how the therapy works. Unless its a very expensive vaccine, which no one would trust at all.
Makes sense. Might be able to do a procedure while in the womb. (I’m not a scientist.)
I see future generations of job security for the snippers.
Wouldn’t you need to remove the cell while it is a zygote?
It seems every few months a new “breakthrough” is announced for cancer, Alzheimer’s, even weight loss etc.
And then nothing is heard again.
Inhuman. Ugh.
Yep, really hard to tell if you’re pregnant let alone diagnose a baby at the zygote.
So unless this is some kind of down syndrom vaccine I don’t see it working. But nobody wants to test that kind of vaccine for obvious reasons.
When I was a medical student, I prayed through many tears for many miracles. Some happened. During the many years since then, many more have happened. Many diseases that were incurable then are not today. Pray that Down’s Syndrome will become one of them.
Wouldn’t this have to be done right after conception? At a time when you certainly would not know the child was downs. Seems rather impossible.
Yup. Good news for laboratory rats, I guess, but not for the rest of us.
It may work much better for IVF, but IVF comes with its own set of issues.
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