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Breakthrough new treatment could REVERSE Down syndrome
Daily Mail UK ^ | August 24, 2025 | STACY LIBERATORE

Posted on 08/25/2025 1:05:38 AM PDT by Morgana

Cutting-edge technology could one day transform treatment for Down syndrome, as researchers have successfully deleted an extra chromosome in lab-grown cells.

Down syndrome - which occurs when a person has three copies of chromosome 21 instead of two - alters brain development and can cause intellectual disability, learning difficulties and other health challenges.

It affects about one in 700 births in the US, with an estimated 250,000 people living with the condition.

Scientists from Mie University in Japan have used CRISPR-Cas9, a DNA-editing tool often described as 'molecular scissors,' to cut away the surplus chromosome in cells.

Their system was able to distinguish the duplicated chromosome from the two original parental copies, ensuring the cell kept one from each parent rather than two identical versions.

Those corrected cells began showing more typical patterns of gene activity and cellular behavior, especially in pathways linked to brain development.

While the results are a striking proof of concept, experts stress that this research is still far from becoming a therapy.

'Removing an extra chromosome from a single cell has been possible for more than a decade, and CRISPR has made the process more precise,' Dr Roger Reeves of Johns Hopkins University School of Medicine told the Daily Mail.

(Excerpt) Read more at dailymail.co.uk ...


TOPICS: Health/Medicine; Science
KEYWORDS: dna; downsyndrome; treatment

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1 posted on 08/25/2025 1:05:38 AM PDT by Morgana
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To: Morgana

I remember discussing this with a scientist way back in 1970.


2 posted on 08/25/2025 2:30:01 AM PDT by Sacajaweau
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To: Morgana

bkmk


3 posted on 08/25/2025 4:05:30 AM PDT by ptsal (Vote R.E.D. >>>Remove Every Democrat ***h)
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To: Morgana

Timing of required surgery would be almost impossible.


4 posted on 08/25/2025 4:12:26 AM PDT by tired&retired (Blessings )
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To: Morgana
Like a two-edged sword, a discovery that offers great hope and ever greater danger.

5 posted on 08/25/2025 5:37:51 AM PDT by BitWielder1 (I'd rather have Unequal Wealth than Equal Poverty)
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To: tired&retired

Without early detection I don’t see how the therapy works. Unless its a very expensive vaccine, which no one would trust at all.


6 posted on 08/25/2025 5:45:12 AM PDT by Bayard
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To: Morgana

Makes sense. Might be able to do a procedure while in the womb. (I’m not a scientist.)


7 posted on 08/25/2025 5:57:35 AM PDT by MayflowerMadam (It's hard not to celebrate the fall of bad people. - Bongino)
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To: Morgana

I see future generations of job security for the snippers.


8 posted on 08/25/2025 6:15:01 AM PDT by Racketeer
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To: Bayard

Wouldn’t you need to remove the cell while it is a zygote?


9 posted on 08/25/2025 6:17:06 AM PDT by tired&retired (Blessings )
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To: Morgana
I wish I could be more excited about this.

It seems every few months a new “breakthrough” is announced for cancer, Alzheimer’s, even weight loss etc.

And then nothing is heard again.

10 posted on 08/25/2025 6:19:38 AM PDT by daler
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To: Morgana

Inhuman. Ugh.


11 posted on 08/25/2025 6:32:21 AM PDT by ichabod1 (lets change our name to the United States of Trump!)
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To: tired&retired

Yep, really hard to tell if you’re pregnant let alone diagnose a baby at the zygote.

So unless this is some kind of down syndrom vaccine I don’t see it working. But nobody wants to test that kind of vaccine for obvious reasons.


12 posted on 08/25/2025 6:46:31 AM PDT by Bayard
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To: Morgana

When I was a medical student, I prayed through many tears for many miracles. Some happened. During the many years since then, many more have happened. Many diseases that were incurable then are not today. Pray that Down’s Syndrome will become one of them.


13 posted on 08/25/2025 7:03:52 AM PDT by Savage Beast (NOTHING enkindles anger, hate, violence, and murderous fury like Truth threatening guarded delusion.)
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To: Morgana

Wouldn’t this have to be done right after conception? At a time when you certainly would not know the child was downs. Seems rather impossible.


14 posted on 08/25/2025 7:10:52 AM PDT by Republican Wildcat
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To: Republican Wildcat
Wouldn’t this have to be done right after conception? At a time when you certainly would not know the child was downs. Seems rather impossible.

At a future technology level? Not necessarily.. There might be ways to fix a number of cells, reintroduce them to the patient, and have progressive improvement as the corrected cells multiply. Probably not a 100% cure, but a solid treatment that moves every patient halfway up the ladder. If every full Down's kid could shift to Mosaic Down's, that would represent a 10-25 pt IQ shift for the condition as a whole. And greatly reduce the severity and range of the many comorbidities that Down's tend to acquire.
15 posted on 08/25/2025 8:21:14 AM PDT by Svartalfiar (-)
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To: daler
I wish I could be more excited about this. It seems every few months a new “breakthrough” is announced for cancer, Alzheimer’s, even weight loss etc. And then nothing is heard again.

Yup. Good news for laboratory rats, I guess, but not for the rest of us.

16 posted on 08/25/2025 9:15:31 AM PDT by fidelis (Ecce Crucem Domini! Fugite partes adversae! Vicit Leo de tribu Juda, Radix David! Alleluia!)
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To: Morgana

It may work much better for IVF, but IVF comes with its own set of issues.


17 posted on 08/25/2025 9:18:41 AM PDT by kosciusko51
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To: Svartalfiar

Good point. of course you would still have the “uncorrected” cells also multiplying. But that seems to be what you imply the rest of the post as to why it would be a cure or 100% prevention. But yes, I see the point of how that would be a vast improvement for these individuals, and many of the problems some of them have is not the learning disability.


18 posted on 08/25/2025 1:23:50 PM PDT by Republican Wildcat
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To: Svartalfiar

Good point. of course you would still have the “uncorrected” cells also multiplying. But that seems to be what you imply the rest of the post as to why it would *not* be a cure or 100% prevention. But yes, I see the point of how that would be a vast improvement for these individuals, and many of the problems some of them have is not the learning disability.


19 posted on 08/25/2025 1:24:27 PM PDT by Republican Wildcat
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