Posted on 05/29/2024 12:49:48 PM PDT by Red Badger
The world's first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030.
The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar. The intravenous treatment will be tested for its efficacy on human dentition, after it successfully grew new teeth in ferret and mouse models with no significant side effects.
"We want to do something to help those who are suffering from tooth loss or absence," said lead researcher Katsu Takahashi, head of dentistry and oral surgery at Kitano Hospital. "While there has been no treatment to date providing a permanent cure, we feel that people's expectations for tooth growth are high."
Following this 11-month first stage, the researchers will then trial the drug on patients aged 2-7 who are missing at least four teeth due to congenital tooth deficiency, which is estimated to affect 1% of people. The team is recruiting for this Phase IIa trial now.
Researchers are then looking at expanding the trial to those with partial edentulism, or people missing one to five permanent teeth due to environmental factors. The incidence of this varies from country to country, but it's estimated around 5% of Americans are missing teeth, with a much higher incidence among older adults.
The medicine itself deactivates the uterine sensitization-associated gene-1 (USAG-1) protein, which suppresses tooth growth. As we reported in 2023, blocking USAG-1's interaction with other proteins encourages bone morphogenetic protein (BMP) signaling, which triggers new bone to generate.
(Excerpt) Read more at newatlas.com ...
I think I dated her 50 years ago.....................
Are you suggesting it comes from inbreeding?
Just sayin’.............🙄
Ladies and gentleman..... start your files.
Just what I need: a new egg tooth.
It’s a tooth-fer!
I guess the meth users have something to legitimately celebrate.
Doesn't climate change kill us all in 2030?
The birth defects this will cause can’t be fathomed.
will it grow teeth in places where we didn’t know we had places??
Just wait til one of these 30 guys sprouts a molar in the middle of his forehead
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Or you chews their food going in and out.
Honeymooning groom to new bride: "Well, I don't know either, but the d@mn thing bit me!"
[I hope it has an off-switch, though.]
“I am the walrus.”
While, you’re at it, please ask Him if he could rethink coronary artery design.
There’s some snake-oil salesman advertising on YouTube about some magic gunk that will repair gums and regrow teeth.
I am skeptical about this, too.
And dental implant companies weep.
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I suspect Dr Bukk has been using this technology to produce his line of “teef” for a while.
https://www.drbukk.com/shop-all-products/
I have something like those around here somewhere.....used to freak people the hell out. Lol!
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