Posted on 04/12/2023 5:36:19 AM PDT by Red Badger
An in-development COVID-19 nasal vaccine that contains a live but weakened coronavirus outperformed several other types of shots in a preclinical study — suggesting that there may be a less painful and more effective way to protect against COVID-19.
The challenge: More than 30 COVID-19 vaccines have been authorized for use in at least one country, and while they’re all designed to help the immune system recognize the coronavirus so that it can stop an infection, they do so in a variety of ways.
The mRNA vaccines, for example, deliver instructions that teach our cells to make the coronavirus’ spike protein, and protein-based shots just inject the spike directly. Adenovirus vaccines use the shells of a cold virus as carriers for the spike instructions, while inactivated vaccines use whole, killed coronaviruses.
Live attenuated vaccines are typically highly effective, durable, and can be stored in refrigerators.
In search of: One thing missing from our COVID-19 vaccine arsenal is a live attenuated vaccine, which uses a live but weakened version of the virus to train the immune system to fight the real thing.
These vaccines aren’t without limitations — because it is possible that the attenuated virus might retain its toxicity in the body, they might not be the best option for people who are immunocompromised.
However, they’re typically highly effective, durable, and can be stored in refrigerators, which makes them easier to distribute than shots that must be frozen. They’re also well understood, as we use them to protect against flu, smallpox, measles, and many other diseases.
What’s new? Several groups are now working to get a live attenuated vaccine for COVID-19 authorized, and a team in Germany has just published positive preclinical data on their candidate, sCPD9, which is delivered via a nasal spray, rather than an injection.
“Overall protection from virus replication, tissue damage, and lung inflammation were significantly better.”
NOUAILLES ET AL. This approach creates what’s known as “local immunity” in the mucus membranes of the nose and mouth, which can prevent the coronavirus from entering the body at all. With injected vaccines, the immune system typically doesn’t spring into action until the coronavirus is in the body, and a person might have already spread the virus to others by then.
Nasal vaccines also have the benefit of being less painful (and, for some, less scary) than injections, which could encourage more people to get vaccinated.
How it works: For their study, the German researchers used hamsters to compare their live attenuated vaccine against BNT162b2, an approved mRNA vaccine developed by BioNTech and Pfizer, and Ad2-Spike, an in-developed adenovirus-based vaccine.
The hamsters were given two doses of vaccine 21 days apart — these were either two doses of the live attenuated vaccine, two doses of the mRNA vaccine, two doses of the adenovirus-based vaccine, or the mRNA vaccine followed by the live attenuated vaccine.
“Our goal is to rapidly scale-up production and advance clinical development.”
VLADIMIR CMILJANOVIC Fourteen days after the second dose, the hamsters were challenged with the coronavirus. The researchers then looked at tissue samples from the animal’s nasal passages and lungs, and discovered that the live attenuated vaccine out performed the others at protecting against infection.
“Overall protection from virus replication, tissue damage, and lung inflammation were significantly better in sCPD9-vaccinated animals,” they wrote.
Looking ahead: A handful of live attenuated vaccines for COVID-19 have made it to human testing — NY-based biotech startup Codagenix’s candidate is in phase 3 trials — and the German researchers hope theirs will be the next to take that major step closer to authorization.
To that end, they’ve teamed up with Swiss startup RocketVax AG to prepare their vaccine for phase 1 clinical trials.
“Our goal is to rapidly scale-up production and advance clinical development towards market access to provide protection against post-COVID symptoms for all,” said RocketVax CEO Vladimir Cmiljanovic.
I can’t remeber the name of it now, but it was showing promise and then it disappeared with he c,aim hat it “needed to be studied more” . I think I had xylitol in it if I recall right
Here is a link to some newer sprays that claim to prevent 99% of viruses
“She said that it has been shown to be effective in the lab against a wide range of viruses, and said that new variants of the coronavirus won’t interfere with its effectiveness, emphasizing: “It contains a broad spectrum antiviral which kills all viruses and all variants.””
“Israel will become the first country where the spray is sold. The Health Ministry has given interim approval for its sale as a medical device suitable for people age 12 and up — meaning it could be used by many who aren’t yet approved for coronavirus vaccines — with packaging stating: “Scientifically tested to kill 99.9% of viruses within 2 minutes.”:
This was from. 2021, and we haven’t heard anything more on it- I’m wondering if it got banned? Can’t have a nasal spray competing with vaccines apparently.
If that suff had worked, the “pandemic” wou,d have been essentially over quickly, and nowhere near as many deaths as they could have admi ksered it to the sickly and elderly with 4 or more comorbities and saved 10’s of 1000s of lives most likely, and Noone would have had to risk vaccine injuries
I had a couple of ill days but bounced back by the weekend. I have had a couple of times where I have felt ill like I was coming down with it, but it stopped.
But I do not know whether I have just been lucky.
Is that supposed to be a bad thing?
wastedyears wrote: “Is that supposed to be a bad thing (being an anti-vaxxer)?”
When one considers the hundreds of millions of lives saved by vaccines, it’s both stupid and bad.
They pushed the jabs on 6 month old babies and kids and young healthy adults, none of whom needed it. Hell, I’m 57 and got through COVID just fine without the jab(s)
20 years ago, my wife was taking my 2 1/2 year old son for another round of vaccines. I made the comment; “Again? I don’t remember having so many.” Two weeks later, a switch flipped in his brain. He didn’t talk again until he was 4 1/2. He’s “on the spectrum”.
I hate the bastards!
We never had the jab nor the covid.
I take D3 and multivitamins along with potassium and magnesium, never even had so much as a sniffle...................
At least one fear I would have is that the attenuated live virus wouldn’t be fully attenuated and then be viable enough to infect cells and proliferate.
I still don’t know if other researchers are breaking up the COVID virion into constituent parts (destroying the viral genome in the process) and exposing the immune system to that. Seems like having the immune system attack the capsid of the virus and the spike protein might be a decent idea. IMHO
The first Polio vaccines had that flaw....................
“When one considers the hundreds of millions of lives saved by vaccines, it’s both stupid and bad.”
That’s one of the tragedies. By lying so badly about Covid shots, people (including myself) are understandably very reluctant to trust any vaccine now.
The government and Big Pharma destroyed 75 years of trust.
Everyone I knew that had Covid (including my Shoa-surviving grandparents) who rinsed their sinuses with salt water using a high volume sprayer (like two cups, one into each nostril) basically had a bad head cold.
The theory in Israel was that it kept the viral load in the lungs down by washing out infected drainage that would otherwise load up the lungs.
Did it myself and it worked.
Jewbacca wrote: “The government and Big Pharma destroyed 75 years of trust.”
I fully understand your point. However, there has always been a vocal minority that disparges vaccines. For example, JFK, jr. who has been on a crusade against vaccines for many years. And, if you examine the history of vaccination, you’ll find the same misrepresentation and mistrust of vaccines since the 1790s. This is nothing new.
Ok why use the term “anti vaxxer”? It’s a tad provocative don’t you think? So if you use inflammatory prose in your post did you believe that would somehow not receive the same response in kind?
Don’t care. For 99.9999% of the population, Covid at worsthas mutated into a bad case of the sniffles.
I use a nasal powder spray from Israel. I believe citrus acid based. Viruses cannot attach. But it made my nose stuffy so I didn’t use it much.
DariusBane wrote: “Ok why use the term “anti vaxxer”? It’s a tad provocative don’t you think? So if you use inflammatory prose in your post did you believe that would somehow not receive the same response in kind?”
The term anti-vaxxer accurately describes the vast majority of the posts to these threads that are overwhelmingly critical of the vaccines. For example where they use provocative terminology like ‘clot shot’, ‘poison’, etc. Where they insist that those who favor the vaccines are guilty of crimes against humanity, that they should be executed under the terms of the Nuremburg Convention. Claims that everyone who is vaccinated will be dead in a short number of years. Do you consider that rhetoric to be provocotive too?
Also of importance is this. Ever since the introduction of vaccination in the 1790s, there has been a vocal minority who peddle fear-mongering arguments against the vaccines. For example, in the 1790s, the smallpox vaccine would turn one into a cow. The vaccines contained bat feces. Now, the claims are the same. The vaccines change your DNA. The vaccines are poison.
If the person spouts anti-vaccine propaganda it is correct to call them an anti-vaxxer.
my not trusting you doesn’t make me an “anti-vaxxer”...
heavy metal wrote: “my not trusting you doesn’t make me an “anti-vaxxer”...”
True, it’s your aversion to vaccines that make you an anti-vaxxer.
my not trusting what you write on free republic doesn’t make me an “anti-vaxxer”...
heavy metal wrote: “my not trusting what you write on free republic doesn’t make me an “anti-vaxxer”...”
Does that mean you’re up to date on your vaccinations?
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