Posted on 04/03/2023 7:27:39 PM PDT by ConservativeMind
A new research paper was published in Aging, titled "Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series."
In this study, researchers reported on a case series of six women who completed a methylation-supportive diet and lifestyle program designed to impact DNA methylation and measures of biological aging.
"The modifiable lifestyle intervention used by participants in this case series was first investigated in a pilot clinical trial in which participants (all men between the ages of 50-72 years) reduced their biological age by an average of 3.23 years as compared to controls [7]. The case series reported on herein was conducted to further the investigation of a modifiable lifestyle intervention that was largely the same in other populations; importantly in women," write the researchers.
The team carried out an intervention consisting of an eight-week program. This program included guidance on diet, sleep, exercise, and relaxation, supplemental probiotics and phytonutrients and nutritional coaching. DNA methylation and biological age analysis (Horvath DNAmAge clock (2013), normalized using the SeSAMe pipeline [a]) was conducted on blood samples at baseline and at the end of the eight-week period.
Five of the six participants exhibited a biological age reduction of between 1.22 and 11.01 years from their baseline biological age. There was a statistically significant (p=.039) difference in the participants' mean biological age before (55.83 years) and after (51.23 years) the 8-week diet and lifestyle intervention, with an average decrease of 4.60 years.
The average chronological age at the start of the program was 57.9 years and all but one participant had a biological age younger than their chronological age at the start of the program, suggesting that biological age changes were unrelated to disease improvement and instead might be attributed to underlying aging mechanisms.
(Excerpt) Read more at medicalxpress.com ...
Really excellent journal article.
Thank you for sharing.
Everytime I read about methylation, I think of the research done by Randy Jirtle at Duke University with agouti mice that are predisposed to cancer, obesity and diabetes. With methylation, he removed the expression of the genetic predisposition in the offspring. Bruce Lipton wrote about this in “Biology of Belief.”
https://www.nature.com/scitable/topicpage/obesity-epigenetics-and-gene-regulation-927/
This subject fascinates me.
It appears that a childhood trauma and the related stress somehow removes the natural methylation protection. I have observed the effect of inter-generational trauma on inherited obesity.
In one very obese woman, I found severe early childhood trauma. The result in testing was more profound than I had ever observed.
We removed the extreme emotion attached to the trauma memories and several months later the woman contacted me that she had lost over 50 lbs without trying.
Decreased methylation due to the stress of the trauma appeared to be the root cause of the obesity.
B-vitamins are very important in methylation.
Still figuring out the details of this puzzle.
Your posted medical articles are a blessing in this process.
Thank You.
Just stumbled onto this very interesting article:
DNA methylation in the pathogenesis of polycystic ovary syndrome
From the article:
“Remarkably, exposure to elevated androgens early in life, such as in women with congenital adrenal hyperplasia and prenatally androgenized animals, correlates with a decline in the negative feedback effect of estradiol and progesterone in the GnRH-mediated release of LH, which is a typical characteristic in women with PCOS (Blank et al. 2006).
A study recently proposed that prenatal exposure to androgens results in aberrant fetal programming in GnRH neurons that impairs their response to the steroid hormones negative feedback in mice (Silva et al. 2018).”
I’m good where I’m at.
If I could do it all over again, I wouldn’t.
If I could start today at any age I wanted I’d pick my current age.
If I could take a drug to make me live forever I wouldn’t.
Joint pain free would be nice but otherwise I’m good.
BFL
How to Support Methylation + Why It’s Important for Your Health
By Jillian Levy, CHHC
May 4, 2022
(Dr Axe website)
https://draxe.com/health/methylation/
My hubby would be on your list too. He is a meat and potatoes guy. He’s 73, and recovering from Covid, colon cancer removal, and chemo. Fatigue is his biggest battle.
He would never do smoothies, any green vegetables except green beans and peas. They kept asking during chemo, any nausea? In 53, nearly 54 yrs married, I’ve known him to be nauseous maybe once.
I guess the longer we live, the longer we have to do something good in the world.
Some things may be up to us, but everyone’s time comes. I have to assume that God has His reasons for someone living to be 105, and someone else dying much younger.
Some things may be up to us, but everyone’s time comes. I have to assume that God has His reasons for someone living to be 105, and someone else dying much younger.
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1000 million years from now, maybe that will seem like an irrelevant difference.
Do you suppose the Earth will be here that far in the future?
If humanity survives that long, I suspect our far descendants will probably be living on other planets by then and won’t even remember Earth...especially if they had originally arrived there as bits of meteor-borne ‘flotsam’.
Maybe not, but things might exist in some form.
Ideas and Ideals live forever. They’re made of Mind, not of Flesh.
Let’s hope that wherever/however Earth Humanity winds up, our best ideas and highest idealism still live.
Well, let me know when your book gets published
Ping for later.
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