Just stumbled onto this very interesting article:
DNA methylation in the pathogenesis of polycystic ovary syndrome
From the article:
“Remarkably, exposure to elevated androgens early in life, such as in women with congenital adrenal hyperplasia and prenatally androgenized animals, correlates with a decline in the negative feedback effect of estradiol and progesterone in the GnRH-mediated release of LH, which is a typical characteristic in women with PCOS (Blank et al. 2006).
A study recently proposed that prenatal exposure to androgens results in aberrant fetal programming in GnRH neurons that impairs their response to the steroid hormones negative feedback in mice (Silva et al. 2018).”