Posted on 06/07/2022 10:21:57 AM PDT by SeekAndFind
Acancer treatment has shown astounding results in a small clinical trial. All of the treated patients, who had a specific form of mid-stage rectal cancer, have since experienced complete remission. Though the findings are based on a sample size of just 18 people, they could hold important implications for treating these particular cancers.
The results of the Phase II trial were published over the weekend in the New England Journal of Medicine . The study involved researchers at the Memorial Sloan Kettering Cancer Center as well as Yale University, and it was sponsored by the pharmaceutical company GlaxoSmithKline.
The trial enrolled volunteers diagnosed with stage II or III rectal cancer, meaning their tumors had begun to grow larger and spread to nearby parts of the body. Their cancer was also determined to be caused by a particular mechanism known as a deficiency in mismatch repair.
Cancers can form for many different reasons. But sometimes, our cells develop mutations that hinder them from being able to fix errors made when DNA is copied within them. These errors can then eventually lead to cancerous cells.
The researchers theorized that their treatment, a lab-made antibody called dostarlimab, might be able to help this subset of patients. It works by inhibiting a protein known as programmed death receptor-1 (PD-1) found in many cancer cells. This inhibition then allows the immune system to recognize the cancer cells as harmful and target them for destruction. The drug was developed by GlaxoSmithKline, and it was given an accelerated approval by the Food and Drug Administration last year for cases of endometrial cancer linked to a mismatch repair deficiency.
The patients were given a dose of dostarlimab every three weeks for six months.
(Excerpt) Read more at msn.com ...
But remarkably, the treatment alone seemed to wholly eradicate their cancer. As of the study’s publication, 18 patients have completed treatment, while 12 have been tracked for at least a year, and none of them have shown signs of their cancer returning so far.
According to the New York Times, the first patient given the drug has remained cancer-free two years later.
That said, the findings are still very early, and it will take much more research with larger-sized studies to confirm the drug’s effectiveness, especially over the long term. Dostarlimab and similar immunotherapy treatments also aren’t side-effect free, and they can rarely cause serious complications like muscle weakness, though no such adverse events were reported in this trial. And the drug doesn’t come cheap, costing $11,000 per dose out of pocket.
And this is the last we will ever hear of it.
I'm willing to end the thousand dollar stipends and free public school and emergency room care for illegal aliens and billions in aid to countries like Ukraine to help our American citizens get cheap cancer treatments.
It’s 18 patients. Too small to reach any conclusions.
Yep. It was a small group, too small to tell anything. Oh well...oh look! A squirrel!!
Translation: We will never hear of this again
FDA will get around to evaluating it in 20 years or so.
Maybe Joe can save it for October’24. Claiming credit for curing cancer might be good for a bump.
They’ll squelch that somehow.
Trust the government to keep something that actually benefits us from being available.
Sure because a 100% success rate in a small sample happens all the time, so it is not statistically significant, right?
Yep. Cancer will never be allowed to be cured. There is too much money to be made. Two of my younger sisters and both my parents died from cancer.
No, it’s not, unfortunately.
From reading that article, all patients had early stage colon cancer. That is not one of the most aggressive and fast growing cancer location. Pancreatic cancer is the worst, followed closely by liver, brain, kidney cancers.
My wife was diagnosed with stage-4 cancer 4 years and 3 months ago. Cancer tumors were present in lung, rib bones, brain, and lymph nodes. I am impressed with the great cancer treatments available today because she is still with us and not doing all that bad considering her and I enjoyed 6 cruises since diagnosis. Since last September 2021 we have enjoyed 5 cruises, and these 5 were less than half full ships and cheap prices.
That would be true if it didn’t work for all of them.
Says the non-entity.
18 is a very small sample size. The next step is to try this drug on a larger sample size.
Joe Biden has done it. He has cured cancer. Amazing. He will forever be known as the man who cured cancer.
phillipa , if you actually read the abstract, you will see that it reports statistical significance at the .05 level, the standard confidence level. 12-0 at 6 months is a pretty impressive score regardless.
I Am Legend is a 2007 American post-apocalyptic action thriller film loosely based on the 1954 novel of the same name by Richard Matheson. Directed by Francis Lawrence from a screenplay by Akiva Goldsman and Mark Protosevich, the film stars Will Smith as US Army virologist Robert Neville. It is set in New York City after a virus, which was originally created to cure cancer, has wiped out most of mankind, leaving Neville as the last human in New York, other than nocturnal mutants.Hmmmmmm... /s
It’s 18 patients. Too small to reach any conclusions.
__________________________________
Other than, 100% were effectively cured of cancer. which, IMO, is a pretty solid indication that something very interesting is happening.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.