Posted on 04/07/2022 8:37:38 PM PDT by ConservativeMind
A diet involving short-term, severe calorie restriction was safe, feasible, and resulted in a decrease of blood glucose and growth factor concentration, reduction in peripheral blood immunosuppressive cells, and enhanced intratumor T-cell infiltration in cancer patients receiving standard-of-care therapy, according to a trial.
Preclinical research has demonstrated that severe calorie restriction in the form of cyclic fasting or fasting-mimicking diet (FMD) has potent anticancer effects when combined with standard pharmacological treatments.
The researchers administered an FMD regimen to the study participants that consisted of a five-day, low-carbohydrate, low-protein, plant-derived diet, which provided up to 600 Kcal on day 1 and up to 300 Kcal on days 2, 3, 4, and 5, for a total amount of up to 1,800 Kcal in five days. The cycle was repeated every three or four weeks for up to a maximum of eight consecutive cycles. Calorie restriction was followed by a refeeding period of 16 to 23 days, during which patients were not subjected to specific dietary restrictions.
In 99 evaluable patients, the FMD regimen reduced the median plasma glucose concentration by 18.6 percent, serum insulin by 50.7 percent, and serum IGF-1 by 30.3 percent.
The researchers found a significant decrease of circulating immunosuppressive myeloid subpopulations and an increase of activated CD8+ T cells.
To investigate the effects of the FMD diet on intratumor immunity, Vernieri and colleagues performed an interim analysis of another ongoing trial (DigesT) testing a five-day FMD cycle seven to 10 days before surgery in early-stage breast cancer and melanoma patients. Specifically, they evaluated the tumor-infiltrating immune cells and transcriptomic immune profiles in 22 breast cancer patients for whom enough tumor tissue had been collected.
This analysis revealed a significant increase in tumor-infiltrating CD8+ T cells and other changes, indicating a functional switch toward an antitumor immune microenvironment following FMD.
(Excerpt) Read more at medicalxpress.com ...
Various cancers were included, but breast and melanoma cancers were called out in the write up.
I wish they had done a comparative between actual fasting and the fast mimicking diet.
Lettuce and celery?
Why not full fast?
I usually forget to eat, not interested in food and a lousy cook. Weigh 115 now, can’t gain because I don’t eat much. My friends “hate” me. LOL
Anyway, I don’t think I’m in danger of cancer, the good Lord willing, and a fair sea. Have had skin cancer though, due to a childhood spent in the sun with no suntan lotion.
i only eat twice a day- always have practically- small sandwhich for breakfast- ham and cheese- no condiments- throw most of the bread to the birds- and at night maybe a 6 ounce steak, or pork or chicken- sometimes a few vegetables or potatoes- but not often- 185- bee this weight since highschool 30 or so years ago— hardly ever go above or below- I’;m just not a big food lover either- do drink 2 sodas a day though- my ‘breakfast’ is around 11 am- dinner usually at 7- even when i was working hard- doing physical labor- if i ate a breakfast then lunch, i would just feel bloated and not well- and couldn’t work as well- so i quit and stuck to 2 meals a day- probably not doing me a lot of good though-
BOOKbump
“ Why not full fast?”
Side effects and risks of a full fast are much worse. The added risks and suffering are not worth it, since the benefits can be achieved in a safer and easier way.
A full fast shuts down bowel movements, which can cause autotoxemia. Also, critical mineral or electrolyte imbalances can occur in some people from a full fast. Sleep suffers a lot more during a full fast.
Having done both, I can report that the fast mimicking diet is a lot more comfortable, and it is much easier to keep working through it.
I fasted over 200?days a year for almost 3 years. My doctors said all systems were go. No negative effects were detected.
I watched a documentary on netflix called the science of fasting. The research was so old most of it had been done in the old soviet union but it clearly showed that fasting for 4 days before chemotherapy results in only tumor cells still looking for and absorbing sugar. Since sugar is the carrying agent in most chemotherapy drugs the cancer cells lap up the chemo with the sugar. The bodies own normal cells are perfectly capable of dealing with short duration starvation diet but the cancer cells are not. Funny how these obvious effects are still not known in this country. Might it have something to do with not being able to charge someone for not eating before chemotherapy.
"The real point of a fasting mimicking diet is to experience both autophagy and apoptosis. Both require that you cut your protein to somewhere in the range of 16 grams per day (or even less). Apoptosis is programmed cell death –– in this case the deaths of senescent cells. Around two or three days into a fast, there’s evidence that your body runs out of cellular debris, so it starts eating its own cells. ... It appears to kick in two or three days after the start of autophagy."
I'll leave it to the diligent to search out the benefits or autophagy,
probably not doing me a lot of good though-
What you’re doing sounds a lot like “intermittent fasting”, which seems to be developing quite a following.
“ I fasted over 200?days a year for almost 3 years”
How did you approach it? Every other day? So many day on, then so many days off?
Thanks I’ll look that up- hadn’t heard of thay term before. My calorie intake is really low- I think the mid morning sandwh8ch and soda only come out to like maybe 400 calories tops, then at night, the meal maybe 600-800 or so? I thunk someone around 180,needs about 2000 a day, more if active? Not sure though.
I didn’t eat Sunday night through Friday night.
I did take electrolytes and if I felt hungry I let a grain of Himalayan Salt dissolve on my tongue. That eliminates the hunger.
Wow, how much weight did you lose?
Hmmm. As your mom might say, eat your veggies.
I eat lots of them, fresh or frozen, tossed in steamer, then served with Trader Joe Soyaki sauce, which I like a lot. Also make a nice omelet a few times a week with avocado slices, tomato slices, white mushroom slices, maybe even some steamed potato slices. Two eggs in ceramic pan. Just yum and cleans up really fast. On alternate mornings, cereal, but nothing too sweet.
The occasional piece of toast but only gluten-free bread. When I stopped eating wheat, my LDL cholesterol went down 40 points in 2 months. I recommend the book, Wheat Belly, by Wm Davis, MD. Your library probably has it.
Another must-read is Grain Brain, by a psychiatrist, David Perlmutter:
https://www.drperlmutter.com/books/grain-brain-by-david-perlmutter/
i do love omellettes- love westerns actually- ham cheese, peppers, onions- when i go to restaurant which isn’t often, i get those- the bread i eat is a spinach or tomatoe basil tortilla wrap, and most of it i throw out to the birds- and keep just enough to keep my brunchwhich together- I used to be a big bread eater- but no more- I especially loved the chewy-er italian breads- dipped in oil=-
if you want to ‘fast’ sort of=- there is stuff called ‘semi elemental diet’ drink that has easy to digest nutrients in it- i went on it for 3 months - i did drink bone broth during that time too- supposed to be good for a person- it’s expensive though- more than $70 for a can- which lasts about 2 weeks or so- it’s called ‘Absorb Plus”
My dad made great Western omelets, but I don’t eat pork since I found out the pigs have higher IQs than dogs, and I would never eat a dog.
Yes indeed, I loved bread too when I lived in San Francisco quite close to Boudin Sourdough Bakery. Terrific stuff, but that was before wheat was genetically modified. No GMOs in our house, not even for the cat.
There are a couple of kinds of bread that are gluten free. Quite expensive and have to be kept in fridge. I buy about a loaf every month. My neighbor’s daughter is a domestic goddess, makes her own bread. She just brought me a loaf of sourdough still warm from the oven and gluten be d@amned, I’m eating it. Best thing since Boudin.
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