Posted on 12/13/2021 6:20:55 AM PST by Red Badger
Scanning electromicrograph of an HIV-infected H9 T cell. Credit: NIAID
NIH scientists developed vaccine platform. An experimental HIV vaccine based on mRNA—the same platform technology used in two highly effective COVID-19 vaccines—shows promise in mice and non-human primates, according to scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. Their results, published in Nature Medicine, show that the novel vaccine was safe and prompted desired antibody and cellular immune responses against an HIV-like virus. Rhesus macaques receiving a priming vaccine followed by multiple booster inoculations had a 79% lower per-exposure risk of infection by simian-human immunodeficiency virus (SHIV) compared to unvaccinated animals. The research was led by Paolo Lusso, M.D., Ph.D., of NIAID’s Laboratory of Immunoregulation, in collaboration with other NIAID scientists, investigators from Moderna, Inc. and colleagues at other institutions.
“Despite nearly four decades of effort by the global research community, an effective vaccine to prevent HIV remains an elusive goal,” said NIAID Director Anthony S. Fauci, M.D., chief of the Laboratory and a paper co-author. “This experimental mRNA vaccine combines several features that may overcome shortcomings of other experimental HIV vaccines and thus represents a promising approach.”
The experimental vaccine works like mRNA COVID-19 vaccines. However, instead of carrying mRNA instructions for the coronavirus spike protein, the vaccine delivers coded instructions for making two key HIV proteins, Env and Gag. Muscle cells in an inoculated animal assemble these two proteins to produce virus-like particles (VLPs) studded with numerous copies of Env on their surface. Although they cannot cause infection or disease because they lack the complete genetic code of HIV, these VLPs match whole, infectious HIV in terms of stimulating suitable immune responses.
In studies with mice, two injections of the VLP-forming mRNA vaccine induced neutralizing antibodies in all animals, the investigators report. The Env proteins produced in the mice from the mRNA instructions closely resembled those in the whole virus, an improvement over previous experimental HIV vaccines. “The display of multiple copies of authentic HIV envelope protein on each VLP is one of the special features of our platform that closely mimics natural infection and may have played a role in eliciting the desired immune responses,” said Dr. Lusso.
The team then tested the Env-Gag VLP mRNA vaccine in macaques. The details of the vaccine regimen differed among subgroups of vaccinated animals but involved priming the immune system with a vaccine modified to optimize antibody creation. The prime was followed by multiple booster inoculations delivered over the course of a year. The boost vaccines contained Gag mRNA and Env mRNA from two HIV clades other than the one used in the prime vaccine. The investigators used multiple virus variants to preferentially activate antibodies against the more conserved “shared” regions of the Env—the target of broadly neutralizing antibodies—rather than the more variable regions that differ in each virus strain.
Although the doses of mRNA delivered were high, the vaccine was well tolerated and produced only mild, temporary adverse effects in the macaques, such as loss of appetite. By week 58, all vaccinated macaques had developed measurable levels of neutralizing antibodies directed against most strains in a test panel of 12 diverse HIV strains. In addition to neutralizing antibodies, the VLP mRNA vaccine also induced a robust helper T-cell response.
Beginning at week 60, immunized animals and a control group of unimmunized macaques were exposed weekly, via the rectal mucosa, to SHIV. Because non-human primates are not susceptible to HIV-1, scientists use a chimeric SHIV in experimental settings because that virus replicates in macaques. After 13 weekly inoculations, two out of seven immunized macaques remained uninfected. The other immunized animals had an overall delay in infection, which occurred, on average, after eight weeks. In contrast, unimmunized animals became infected on average after three weeks.
“We are now refining our vaccine protocol to improve the quality and quantity of the VLPs produced. This may further increase vaccine efficacy and thus lower the number of prime and boost inoculations needed to produce a robust immune response. If confirmed safe and effective, we plan to conduct a Phase 1 trial of this vaccine platform in healthy adult volunteers,” said Dr. Lusso.
Reference: “A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques” by Peng Zhang, Elisabeth Narayanan, Qingbo Liu, Yaroslav Tsybovsky, Kristin Boswell, Shilei Ding, Zonghui Hu, Dean Follmann, Yin Lin, Huiyi Miao, Hana Schmeisser, Denise Rogers, Samantha Falcone, Sayda M. Elbashir, Vladimir Presnyak, Kapil Bahl, Madhu Prabhakaran, Xuejun Chen, Edward K. Sarfo, David R. Ambrozak, Rajeev Gautam, Malcom A. Martin, Joanna Swerczek, Richard Herbert, Deborah Weiss, Johnathan Misamore, Giuseppe Ciaramella, Sunny Himansu, Guillaume Stewart-Jones, Adrian McDermott, Richard A. Koup, John R. Mascola, Andrés Finzi, Andrea Carfi, Anthony S. Fauci and Paolo Lusso, 9 December 2021, Nature Medicine. DOI: 10.1038/s41591-021-01574-5
NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses.
NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases.
Regards,
Safe and effective!
PolitiFact labeled RFK Jr as “Pants On Fire” for labeling the COVID-19 vaccine as being deadly
Anybody else here remember back to the beginnings of this crap?
There was a report that supposedly proved that the virus was man made.
It was because the COVID virus had specific elements of the HIV AIDS virus that could not have happened naturally.
That story didn’t stay around long. It was buried as part of the Trump conspiracy.
It’s safe and effective.
I won’t come in your mouth.
The 2020 election was the most honest in history.
Trump is a Russian spy.
Biden is mentally competent.
Because it is so safe and effective, the drug companies demand a 100% liability shield.
Do the Dems/Rino’s ever tell the truth?
Oh, btw, you can mix and match covid “vaccines”...just ask Newson, the Calif Governor who did...worked REAL well!
That's some funny shit right there.
dayum
I remember that story - I saw a older virologist on a British news show (I think it was British) saying this as a matter of fact and he said he could say it because he is no longer funded by anyone, so he is free to speak.
I’ll never forget that clip.
mRNA has it’s place with specific diseases like HIV and cancers where they are targeted and they aren’t contually forming variants
Yeh, safe and effective way to get rid of gay people. 😣
“Experimental mRNA HIV Vaccine Safe, Shows Promise in Animals...”
Or...animals could just stop having unsafe sex.
The all have the same cell destroying virus and nano Id chips..no problem
https://rumble.com/vqmst3-traitor-joe-biden.html
“the novel vaccine was safe”
Been seeing that WAY to much! It “was safe” if it never was injected in victims.
Therefore, all those have AIDS, engage in Homosexual acts, use illegal drugs or frequent Gay establishements, should be required to get the jab on penalty of death.
“mRNA—the same platform technology used in two highly effective COVID-19 vaccines”
Major typo there. Should have read: two highly INeffective Covid-19 vaccines.
They are already under a penalty of death............................
If fake vax is called effective, this is a load of crappola. Discontinue reading.
Perhaps the number one thing this experimental vax has going for it is that it DOES NOT contain the spike protein.
Good point! Hadn’t thought about that!........................
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