Posted on 12/07/2021 10:50:18 AM PST by SeekAndFind
The Cleveland Clinic released a statement today announcing some unexpected but exciting news: Viagra may be an effective preventative for Alzheimer’s Disease (AD).
A new Cleveland Clinic-led study has identified sildenafil – an FDA-approved therapy for erectile dysfunction (Viagra) and pulmonary hypertension (Ravatio) – as a promising drug candidate to help prevent and treat Alzheimer’s disease
The research team, led by Feixiong Cheng, Ph.D., of Cleveland Clinic’s Genomic Medicine Institute, made the discovery as part of a data-mining study. They performed a large-scale computational analysis of medical insurance data from over 7 million patients, evaluating medicines already FDA-approved and in use as possible candidates for repurposing as therapeutics for the devastating disease.
Sildenafil came out on top, associated with a 69% (snicker) reduction in the incidence of AD in patients who took the drug.
The researchers then went on to create an AD-affected brain cell model on which they further tested sildenafil’s effect on the disease. The results here were promising as well:
In the model, they found that sildenafil increased brain cell growth and decreased hyperphosphorylation of tau proteins (a hallmark which leads to neurofibrillary tangles), offering biological insights into how sildenafil may influence disease-related brain changes.
As usual in the early stages of drug assessment, more research needs to be performed before sildenafil can definitively be declared an effective treatment for Alzheimer’s:
“Because our findings only establish an association between sildenafil use and reduced incidence of Alzheimer’s disease, we are now planning a mechanistic trial and a phase II randomized clinical trial to test causality and confirm sildenafil’s clinical benefits for Alzheimer’s patients,” said Dr. Cheng. “We also foresee our approach being applied to other neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis, to accelerate the drug discovery process.”
(Excerpt) Read more at pjmedia.com ...
I can’t believe this came up again!
Don’t tell Joe.
Hard to believe!
Ping ...
There’s hope for us yet!
Problem,
Now we will not be able to ***k and forget!
I’m 77....too tired....forget it...
Remember, Joe called his doctor after the election lasted longer than four hours...
69% reduction in incidence? Is that a coincidence? 😅😆
this news is big
Isn’t that an off-label use?! Has the FDA recommended that use?
Viagra related news always is on the rise.
Honey!
I think I will pass on this one too. I’m 88 and I still don’t want to grow a beard.
Fix two heads with one pill?
There is always stiff competition from the generics...
Scroll down a little more than halfway on the left side. You’ll see that Ivermectin is #2 in recommendations.
https://www.covid19treatmentguidelines.nih.gov/tables/table-2e/
21st Century Headline
Nan, I think it’s something else they want to grow.
A two-fer. Fix both heads at once.
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