Posted on 09/30/2021 1:13:38 PM PDT by nickcarraway
A likely cause of Alzheimer’s disease offers a significant finding that offers potential new prevention and treatment opportunities for Australia’s second-leading cause of death.
Ground-breaking new Curtin University-led research has discovered a likely cause of Alzheimer’s disease, in a significant finding that offers potential new prevention and treatment opportunities for Australia’s second-leading cause of death.
The study, published in the prestigious PLOS Biology journal and tested on mouse models, identified that a probable cause of Alzheimer’s disease was the leakage from blood into the brain of fat-carrying particles transporting toxic proteins.
Lead investigator Curtin Health Innovation Research Institute (CHIRI) Director Professor John Mamo said his collaborative group of Australian scientists had identified the probable ‘blood-to-brain pathway’ that can lead to Alzheimer’s disease, the most prevalent form of dementia globally.
“While we previously knew that the hallmark feature of people living with Alzheimer’s disease was the progressive accumulation of toxic protein deposits within the brain called beta-amyloid, researchers did not know where the amyloid originated from, or why it deposited in the brain,” Professor Mamo said.
“Our research shows that these toxic protein deposits that form in the brains of people living with Alzheimer’s disease most likely leak into the brain from fat carrying particles in blood, called lipoproteins.
“This ‘blood-to-brain pathway’ is significant because if we can manage the levels in blood of lipoprotein-amyloid and prevent their leakage into the brain, this opens up potential new treatments to prevent Alzheimer’s disease and slow memory loss.”
Building on previous award-winning research that showed beta-amyloid is made outside the brain with lipoproteins, Professor Mamo’s team tested the ground-breaking ‘blood-to-brain pathway’ by genetically engineering mouse models to produce human amyloid-only liver that make lipoproteins.
“As we predicted, the study found that mouse models producing lipoprotein-amyloid in the liver suffered inflammation in the brain, accelerated brain cell death, and memory loss,” Professor Mamo said.
“While further studies are now needed, this finding shows the abundance of these toxic protein deposits in the blood could potentially be addressed through a person’s diet and some drugs that could specifically target lipoprotein amyloid, therefore reducing their risk or slowing the progression of Alzheimer’s disease.”
Alzheimer’s WA Chairman Adjunct Professor Warren Harding said the findings may have a significant global impact for the millions of people living with Alzheimer’s disease.
“Having universities like Curtin working with the pharmaceutical industry is important if we are to tackle this devastating disease,” Mr. Harding said.
“In Australia, approximately 250 people are diagnosed with dementia daily, adding to the staggering half a million Australians who are already living with dementia. Without significant medical advances like the breakthrough Professor Mamo’s team has made, it is estimated that the number of Australians living with dementia will exceed one million by 2058. This has a significant impact on families, carers and communities.”
Professor Mamo and his research team’s previous research in this area was awarded the NHMRC-Marshall and Warren Award for the most innovative and potentially transformative research.
Currently, the team is conducting a clinical trial, the Probucol in Alzheimer’s-clinical trial, which is based on previous findings that a historic cardiovascular agent lowers lipoprotein-amyloid production and supports cognitive performance in mice.
For more on this research, see Protein Made in the Liver May Cause Alzheimer’s Disease in the Brain.
Reference: “Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype” by Virginie Lam, Ryusuke Takechi, Mark J. Hackett, Roslyn Francis, Michael Bynevelt, Liesl M. Celliers, Michael Nesbit, Somayra Mamsa, Frank Arfuso, Sukanya Das, Frank Koentgen, Maree Hagan, Lincoln Codd, Kirsty Richardson, Brenton O’Mara, Rainer K. Scharli, Laurence Morandeau, Jonathan Gauntlett, Christopher Leatherday, Jan Boucek, John C. L. Mamo, 14 September 2021, PLOS Biology. DOI: 10.1371/journal.pbio.3001358
Lucky for me, I can't eat much of any meat fat. Alpha-gal allergy - https://en.wikipedia.org/wiki/Alpha-gal_allergy
Alpha-gal allergy — or mammalian meat allergy (MMA)[1] — is a type of meat allergy characterized by a delayed onset of symptoms (3-8 hours) after ingesting mammalian meat and resulting from past exposure to tick bites. It was first reported in 2002. Symptoms of the allergy include rash, hives, nausea or vomiting, difficulty breathing, drop in blood pressure, dizziness or faintness and severe stomach pain.[2]
Got a bunch of tick bites while cleaning up the mo-in-law's property years ago. Took me a while to figure out why I was waking up at 2am with the hives. Finally associated it with ribeye night. The allergy subsides after a while but I live in the forest so another Lone Star tick bite and it comes back. Worst reaction I had was from a ham made from homegrown pig/hog. Basically anaphylactic shock. Dropped out of consciousness twice. Now if I eat beef or some cuts of pork, I take a Benadryl before bed. I also have an epipen. Never was real big on fat and have always trimmed it off but that marbling is fat too. We've got meat goats and will be taking any bucklings born from now on for the freezer. Very lean meat.
Well if you were going by what Freepers post, you wouldn’t have even needed to click on this thread as you would already know Vitamin D cures Alzheimer’s...
as well as everything else.
Vitamin D is all you need.
And the amount they advise people take is crazy.
People in cold countries for a long time advised to take 10 micrograms of vitamin d per day. If taking more was good, they would have noticed.
Norwegians are smart. The Danish are smart, too.
Many people here take in one month what they took in two years.
WAY too late for Joe, The Surrender Monkey!
My favorite flavors in any sugar-laden confection. If that counts.
Ya sure you got the decimal point in the right place there, Bigly?
Any food that tastes good and is filling, of course!
Would substituting an occasional sherbet for the ice cream suffice?
K2 must be important if they named a mountain after it.
I was thinking about vitamin c.
Not as important as the famous Mt. Everst climber that Hillary was named after.
The “toxic” protein in question, beta amyloid is normal to nerve cell growth and repair, in most people even into older age. And normally excesses of the protein are broken up and sent back as waste. The “leak” phenomena attributed to Alzheimers patients seems to be a situation where there is a breakdown in the normal dispensation of excess beta amyloid the brain is not in need of. Maybe further research needs to understand the why of that latter point.
Bkmrk
Alzheimer’s is not the only form of dementia. I wonder if this will also be helpful with other forms of dementia.
Is this the 1500th or 1600th ground breaking study?
It’s all in the same grocery section.
I have had a bad reaction to an MRI...not as bad as the wife of chuck Norris though. I wish i had read up on what to take before hand but for this one its not vitamin D!
Btw..i woke up in the middle of the night after that MRI with such bizarre reactions i wondered if i finally had covid. Read up on the contrast dye before you get one.
That’s been my diet for the last couple of years (except when I cook for the wife some nights), and I’ve gone from 250 to 225. Honest Injun.
This is a completely useless post. It doesn’t say what diet change is needed.
It no different than me saying “the answer for limitless free energy is already in everyone’s kitchen cabinets in a form that can be directly tapped, but follow on research will be needed.”
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