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Groundbreaking Research Identifies Likely Cause of Alzheimer’s Disease – Potential for New Treatment [Diet]
SciTechDaily ^ | SEPTEMBER 15, 2021

Posted on 09/30/2021 1:13:38 PM PDT by nickcarraway

A likely cause of Alzheimer’s disease offers a significant finding that offers potential new prevention and treatment opportunities for Australia’s second-leading cause of death.

Ground-breaking new Curtin University-led research has discovered a likely cause of Alzheimer’s disease, in a significant finding that offers potential new prevention and treatment opportunities for Australia’s second-leading cause of death.

The study, published in the prestigious PLOS Biology journal and tested on mouse models, identified that a probable cause of Alzheimer’s disease was the leakage from blood into the brain of fat-carrying particles transporting toxic proteins.

Lead investigator Curtin Health Innovation Research Institute (CHIRI) Director Professor John Mamo said his collaborative group of Australian scientists had identified the probable ‘blood-to-brain pathway’ that can lead to Alzheimer’s disease, the most prevalent form of dementia globally.

“While we previously knew that the hallmark feature of people living with Alzheimer’s disease was the progressive accumulation of toxic protein deposits within the brain called beta-amyloid, researchers did not know where the amyloid originated from, or why it deposited in the brain,” Professor Mamo said.

“Our research shows that these toxic protein deposits that form in the brains of people living with Alzheimer’s disease most likely leak into the brain from fat carrying particles in blood, called lipoproteins.

“This ‘blood-to-brain pathway’ is significant because if we can manage the levels in blood of lipoprotein-amyloid and prevent their leakage into the brain, this opens up potential new treatments to prevent Alzheimer’s disease and slow memory loss.”

Building on previous award-winning research that showed beta-amyloid is made outside the brain with lipoproteins, Professor Mamo’s team tested the ground-breaking ‘blood-to-brain pathway’ by genetically engineering mouse models to produce human amyloid-only liver that make lipoproteins.

“As we predicted, the study found that mouse models producing lipoprotein-amyloid in the liver suffered inflammation in the brain, accelerated brain cell death, and memory loss,” Professor Mamo said.

“While further studies are now needed, this finding shows the abundance of these toxic protein deposits in the blood could potentially be addressed through a person’s diet and some drugs that could specifically target lipoprotein amyloid, therefore reducing their risk or slowing the progression of Alzheimer’s disease.”

Alzheimer’s WA Chairman Adjunct Professor Warren Harding said the findings may have a significant global impact for the millions of people living with Alzheimer’s disease.

“Having universities like Curtin working with the pharmaceutical industry is important if we are to tackle this devastating disease,” Mr. Harding said.

“In Australia, approximately 250 people are diagnosed with dementia daily, adding to the staggering half a million Australians who are already living with dementia. Without significant medical advances like the breakthrough Professor Mamo’s team has made, it is estimated that the number of Australians living with dementia will exceed one million by 2058. This has a significant impact on families, carers and communities.”

Professor Mamo and his research team’s previous research in this area was awarded the NHMRC-Marshall and Warren Award for the most innovative and potentially transformative research.

Currently, the team is conducting a clinical trial, the Probucol in Alzheimer’s-clinical trial, which is based on previous findings that a historic cardiovascular agent lowers lipoprotein-amyloid production and supports cognitive performance in mice.

For more on this research, see Protein Made in the Liver May Cause Alzheimer’s Disease in the Brain.

Reference: “Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype” by Virginie Lam, Ryusuke Takechi, Mark J. Hackett, Roslyn Francis, Michael Bynevelt, Liesl M. Celliers, Michael Nesbit, Somayra Mamsa, Frank Arfuso, Sukanya Das, Frank Koentgen, Maree Hagan, Lincoln Codd, Kirsty Richardson, Brenton O’Mara, Rainer K. Scharli, Laurence Morandeau, Jonathan Gauntlett, Christopher Leatherday, Jan Boucek, John C. L. Mamo, 14 September 2021, PLOS Biology. DOI: 10.1371/journal.pbio.3001358


TOPICS: Food; Health/Medicine; Science
KEYWORDS: alzheimers; alzheimersdisease; diet; dsj03; health; research
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1 posted on 09/30/2021 1:13:38 PM PDT by nickcarraway
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To: nickcarraway

bookmark


2 posted on 09/30/2021 1:15:43 PM PDT by GOP Poet (Super cool you can change your tag line EVERYTIME you post!! :D. (Small things make me happy))
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To: nickcarraway

Another $39.95 bottle of something will be in the works...


3 posted on 09/30/2021 1:17:48 PM PDT by BiglyCommentary
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To: nickcarraway

https://en.wikipedia.org/wiki/Lipoprotein

No help at all. What kinds of foods do these lipoproteins come from?


4 posted on 09/30/2021 1:18:15 PM PDT by Pollard (Some people like to argue just to argue.)
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To: Pollard

Steak, potatoes and beeh (Aussie beer)


5 posted on 09/30/2021 1:23:46 PM PDT by steve86 (Prophecies of Maelmhaedhoc O'Morgair (Latin form: Malachy))
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To: Pollard

“No help at all.”

That’s why I skipped reading the article. I figured another Freeper would do it for me. Thanks


6 posted on 09/30/2021 1:24:24 PM PDT by Cold Heart
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To: BiglyCommentary

or more likely

“treatments could be available within 5 years...”

and in 5 years -— *Crickets*


7 posted on 09/30/2021 1:24:25 PM PDT by qam1 (There's been a huge party. All plates and the bottles are empty, all that's left is the bill to pay)
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To: Pollard

Meat, of course! It’s been a while, but as I understand it a lipoprotein carries fat molecules. Fat is not water soluble so it needs to be encapsulated and transported inside a molecule that is water soluble. It is interesting that a molecule that large can cross the blood brain barrier but I’m no expert.

I am in no position to dispute the theory but wonder how much of this is tainted by politics like so much science these days. Meaning, move to scare societies away from animal proteins.


8 posted on 09/30/2021 1:25:54 PM PDT by monkeyshine (live and let live is dead)
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To: nickcarraway

I’ve been told that as long as I stick to my diet of pizza, ice cream, and beer, all will be well.


9 posted on 09/30/2021 1:27:00 PM PDT by Telepathic Intruder
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To: nickcarraway

Is this good news or bad news for Joe Biden, I wonder?


10 posted on 09/30/2021 1:27:24 PM PDT by Richard Axtell (As if.)
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To: BiglyCommentary

Another $39.95 bottle of something will be in the works...

“Currently, the team is conducting a clinical trial, the Probucol in Alzheimer’s-clinical trial, which is based on previous findings that a historic cardiovascular agent lowers lipoprotein-amyloid production and supports cognitive performance in mice”

There you have, it soon to be at local CVS and Walgreens for a low, low price of $36.95 in the 7 day size and $61 for the 14 day supply. Use the above promo code to get the 1 month supply for only $110


11 posted on 09/30/2021 1:29:35 PM PDT by PIF (They came for me and mine ... now its your turn)
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To: Cold Heart
I figured another Freeper would do it for me. Thanks

Well if you were going by what Freepers post, you wouldn't have even needed to click on this thread as you would already know Vitamin D cures Alzheimer's...

as well as everything else.

Vitamin D is all you need.

12 posted on 09/30/2021 1:31:03 PM PDT by qam1 (There's been a huge party. All plates and the bottles are empty, all that's left is the bill to pay)
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To: Telepathic Intruder

I’ve been told that as long as I stick to my diet of pizza, ice cream, and beer, all will be well.


I think that’s correct. Maybe add a lemon or orange occasionally.


13 posted on 09/30/2021 1:31:52 PM PDT by TTFX ( )
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To: Pollard
What kinds of foods do these lipoproteins come from?

Good question, of course. I didn't see any mention of a food-to-brain path taken by the offending molecule from your sandwich; OR instead, whether the molecule forms from an interaction with something else you've eaten around the same time, or . . .

14 posted on 09/30/2021 1:33:01 PM PDT by SamuraiScot
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To: nickcarraway

I have come across such a “potential” groundbreaking medical news many times since I learnt English. But what could not be treated thirty years ago are still not treated


15 posted on 09/30/2021 1:33:30 PM PDT by Lee25 ( )
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To: qam1
Vitamin D is all you need.

and K2...

16 posted on 09/30/2021 1:34:49 PM PDT by 1Old Pro (Let's make crime illegal again!)
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To: Pollard

Don’t you worry they will have a Vaccine for that.


17 posted on 09/30/2021 1:35:15 PM PDT by ImJustAnotherOkie (All I know is The I read in the papers.)
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To: Pollard

I think it’s probably more related to how your body might be predisposed to process your food. Two people can eat the same stuff—one gets AD, the other just gets old.


18 posted on 09/30/2021 1:36:04 PM PDT by Vermont Lt
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To: nickcarraway

Can’t they suck it out?


19 posted on 09/30/2021 1:38:31 PM PDT by ARW
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To: BiglyCommentary

...probably already working on a vaccine


20 posted on 09/30/2021 1:42:17 PM PDT by Mr Radical (In times of universal deceit, telling the truth is a revolutionary act)
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