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Corona Virus Daily Thread #48 COVID-19 4/25/2020
many | 4/25/2020 | many

Posted on 04/25/2020 4:04:53 AM PDT by RaceBannon

New Thrtead, starting 4/25/2020


TOPICS: Business/Economy; Health/Medicine; Reference; Science
KEYWORDS: coronavirus; covid19; epidemic; pandemic
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To: RummyChick

Tom Terific
Tom Terific
5 hours ago
Excessive ROS production is indeed part of the inflammatory process. What complicates it is that LOW levels of ROS, from sources such as the mitochondria and NADPH oxidase, are part of normal cellular physiology, serving a signaling role, switching activities of key enzymes on and off by reversible redox reactions. Hydrogen peroxide is heavily involved in such normal signaling. Under normal conditions, the levels of ROS are kept under control by SOD/catalase and the glutathione redox system he mentions here. But if these cellular antioxidant systems’ capacity to maintain ROS at physiological levels is exceeded, then you get oxidant stress. And that can trigger inflammation. Even inflammation plays a normal role in host defense against pathogens, and as an initial step in the the repair process after an injury, and as part of that normal response, there are steps to tamp that inflammation back down once it’s no longer needed. Like excess ROS, it’s when inflammation gets out of control that problems arise. Finally, inflammatory cells themselves, e.g. macrophages, neutrophils, actually do their thing by generating ROS—it’s part of how they attack invading pathogens. Unfortunately, other things can trigger an inflammatory response besides an invading pathogen, and if that inflammatory response becomes dysregulated, diseases can result. Most of the big diseases plaguing Western society these days—cardiovascular disease, cancer, arthritis, inflammatory bowel disease, type 2 diabetes, autoimmune disorders, ischemia-reperfusion injury, etc. all have ROS-associated inflammation at their root. This has been recognized for decades now, and it is a huge area of research interest in biomedicine


501 posted on 04/29/2020 7:56:25 PM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
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To: RummyChick

b. ho
4 hours ago
In an other video Dr. Seheult states he takes Quercetin + zinc + vit c + vit d + (help me here someone) as a prophylaxis to prevent infection.

2

Bernardo Cantu
Bernardo Cantu
4 hours ago
@b. ho and NAC it looks like.


502 posted on 04/29/2020 7:59:39 PM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
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To: RummyChick

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567541/

Curcumin induced oxidative stress attenuation by N-acetylcysteine co-treatment: a fibroblast and epithelial cell in-vitro study in idiopathic pulmonary fibrosis


503 posted on 04/29/2020 8:04:55 PM PDT by RummyChick ( Yeah, it's Daily Mail. So what.)
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To: mrsmith

I thought to replace mine early (finger device) in the pandemic and no luck at the local pharm. Another hoarding item, I suppose. OTOH, not so much demand meant not so many on the shelves to begin with.

The good news is, if you have a 2019-20 fitness tracker, it probably has a passable spo2 function.

According to website, wareable:

the “Charge 3, Fitbit Ionic or any Versa smartwatch” has the function but “Inspire or Alta trackers don’t”

“Garmin... Fenix 6X, Fenix 5X, Vivoactive 4 and Forerunner 245/645/945”

” the Withings ScanWatch”

you can find some fluff info, here:
https://www.wareable.com/wearable-tech/pulse-oximeter-explained-fitbit-garmin-wearables-340

or do some deepdive research on a brand of your choice


504 posted on 04/29/2020 8:05:16 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017))
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To: mrsmith

‘chicken manure’

Did the local fencing contractor run out of temp chain-link panels? Or is the goal to burn the grass off with hot fertilizer while spreading a goodly share of chicken lice? Crazy swedes. Its a sure bet that fertilizer is going to end up where the city fathers didn’t expect it to end up


505 posted on 04/29/2020 8:12:15 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017))
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To: blueplum

Why would they be trying to prevent a festival? I thought Sweden was open?


506 posted on 04/29/2020 8:13:06 PM PDT by Black Agnes
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To: Black Agnes
That would make too much sense.

Much more intelligent to go with the half a$$ed approach, destroy the economy and reopen when infections are at high levels.

507 posted on 04/29/2020 8:20:30 PM PDT by riri (If people still dropping, most aint shopping.)
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To: blueplum

Saw an article that said many “smartwatches” had the ability,but FDA disapproved.
Don’t know if they’re accurate enough.

But a person who came for treatment of covid symptoms should be given one by the hospital if sent home

There’s still the coagulation issue, but I’m assuming that comes after the oxygen issue.


508 posted on 04/29/2020 8:20:49 PM PDT by mrsmith (Dumb sluts (M / F) : Lifeblood of the Media, Backbone of the Democrat/RINO Party!)
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To: cherry

” illnesses not addressed because we had to save some frail sickly elderly will result in many more deaths of 40yros..”

well, just how many ‘illnesses not addressed’ do 40yo’s actually have? For the most part they’re as healthy as 30yo’ds (USA). Those ‘frail elderly’ built the world you live in. Their lives are no less valuable. And, foundational to western civilization, you’re morally obligated to care about them. A lot of shootings and stabbings and overdoses have been delayed, tho - even the criminals stayed inside - as well as those who use the ER as a day clinic for minor complaints - guess what age group they are?

p.s., nobody has been denied critical to life care. The dialysis centers are still running. Shrinks and docs are available by telemed. Babies are still being born. It’s smart science to delay chemo/radiation/surgery treatments that can be delayed and use that time for the patient to continue to build strength, than to run the risk of catching CCPVirus post-radiation/surgery while the immune system is on the floor. Emergencies are still being taken care of.


509 posted on 04/29/2020 9:13:39 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017))
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To: mrsmith

https://www.khmertimeskh.com/50718559/vietnamese-soldiers-still-at-disputed-border-stretch/

“During the inspection they found that Vietnamese soldiers had erected tents in nine locations along the disputed border stretch in Koh Thom district’s Dambok Chev station, which is situated next to Vietnam’s An Giang province.”

Cambodia and ‘Nam … and China.


510 posted on 04/29/2020 9:17:34 PM PDT by mrsmith (Dumb sluts (M / F) : Lifeblood of the Media, Backbone of the Democrat/RINO Party!)
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To: RummyChick; Black Agnes
I think medcram has it figured out...at least why things are happening the way they are

It was an interesting presentation today. One correction to his presentation was SOD2 is in the mitochondria, SOD3 is secreted cellularly and SOD1 is localized to the cytosol and all other cellular organelles.

I think they are on to something and the NAC is a critical adjunct for stimulation of glutathione peroxidase (cysteine pathway). That is one ROS scavenger. There is the other side which I find interesting and that is the action of cysteamine and hypotaurine as the other ROS scavengers.

We (our group) have observed loss of PANK function in metabolic syndrome. We have't delved into it and it is just an observation related to our work. That would explain the reduction of all ROS scavengers.

I am highly anticipating the next lecture. I have avoided confirmation bias related to our work and this corona virus. I suspect Pantethine may play a prophylactic role along with NAC. It is another very affordable over the counter metabolite. Pantethine is the disulfide bond of pantetheine and converts to cysteamine and B5 (mostly) in the lumina of the intestine. Cysteamine then converts via cysteamine deoxygenase to hypotaurine. Both NAC and pantethine may provide the exogenous supplementation for the ROS scavengers.

An older publication of the actions of cyteamine and hypotaurine: The antioxidant action of taurine, hypotaurine and their metabolic precursors

I'll be following this closely. I stand by the 46% of Americans have an underlying disease state that makes them vulnerable to this virus.
511 posted on 04/29/2020 9:34:16 PM PDT by PA Engineer (Liberate America from the Occupation Media.)
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To: DEPcom

could it be because Germany’s neighbors shut their borders long before Germany shut theirs? (5,000 cases Mar 15 - 162,000 cases rounded April 28)
but, is Germany actually paralleling France? 5,000 cases Mar 15, April 28 166,000 cases (rounded)


512 posted on 04/29/2020 9:37:46 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017))
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To: Black Agnes
PAE has posted a lot on NAC. I think he speaks highly of the timed release version.

Yes I do. Difficult to swallow for some. I trust Jarrows products and QC/QA.

Jarrow Formulas N-A-C Sustain, Supports Liver and Lung Function, 600 mg, 100 Sustain tabs

Dosing is still an unknown with this virus.
513 posted on 04/29/2020 9:38:43 PM PDT by PA Engineer (Liberate America from the Occupation Media.)
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To: ETCM

the early Wuhan numbers were 17% of those admitted went to ICU and of that 6% died.

Your county numbers are on target with 22% hospitalized, (avg 80% mild/asymptomatic) and far better than the Wuhan numbers.


514 posted on 04/29/2020 9:47:03 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017))
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To: Black Agnes

Yes, I recall some Dr. saying all we had to do was just stay home for a month. However, you can’t make exceptions for going out for groceries, and all the other exceptions that were made to truly kill the virus that way.

Everyone would have to have had a prepper pantry of everything they needed. We could have done it, but many people could not. Considering what happened with toilet paper, I don’t guess they could have made an announcement —something like stock up for a month—shut down coming. LOL
Talk about empty shelves and fights...

We have not visited a grocery store since the end of February, and we only went twice in February for produce and milk—but that wasn’t really a necessity we could have just used powdered milk and frozen veggies and skipped the salad.

If only there was still an old fashioned milkman to bring dairy products, I’d be happy to never visit the grocery store again. LOL


515 posted on 04/29/2020 9:58:39 PM PDT by greeneyes ( Moderation In Pursuit of Justice is NO Virtue--LET FREEDOM RING)
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To: mrsmith

“Karen”: such a blatantly racist meme...
The media will eat it up.


516 posted on 04/29/2020 10:15:54 PM PDT by mrsmith (Dumb sluts (M / F) : Lifeblood of the Media, Backbone of the Democrat/RINO Party!)
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To: Black Agnes

not open at all
Mar 2 - flights from China/Iran restricted. Iran airlines landing permit pulled.
Mar 6 - restrict flights to Italy and SoK
First restrictions on hospital visits/elderly in pubic Mar 10
Mar 11 - banned groups of 500
Mar 14 - all int’l travel discouraged (not that there were flights avail)
Mar 15ish - salary package
Mar 16 - tougher elderly restrictions and work at home orders. ( by April 16 about 50% were working at home)
Mar 17 - secondary and university schools closed
Mar 19 - no unnecessary travel within Sweden
Mar 24 - restrictions on bars and restaurants -social distance or be shutdown
Mar 27 banned groups of 50 under threat of jail.
End of March -40-60K Swedes stranded outside Sweden
Apr 1 - nursing homes closed to visitors

https://en.wikipedia.org/wiki/2020_coronavirus_pandemic_in_Sweden


517 posted on 04/29/2020 10:16:52 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017))
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To: RaceBannon; SunkenCiv

Sorry, Civ, Race broke your record for most links in a single post.


518 posted on 04/29/2020 10:19:53 PM PDT by Nachoman (Following victory, its best to reload.)
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To: RummyChick

In an other video Dr. Seheult states he takes Quercetin + zinc + vit c + vit d + (help me here someone) as a prophylaxis to prevent infection.
*******************************************************************************
I wrote it down:

Zinc up to 50 mg—don’t do this too long as it’s too much
Quercitin-250 mg x2/day (zinc ionophore)
Green Tea—(can be 1 pill/day)
Melatonin 1-10mg@night for good sleep
Vit. C 250-500 mg x2/day
Vit. D3 — Stop if you get COVID

Interesting — I wonder how much he weighs?


519 posted on 04/29/2020 10:21:46 PM PDT by greeneyes ( Moderation In Pursuit of Justice is NO Virtue--LET FREEDOM RING)
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To: greeneyes

Seriously. I don’t get the toilet paper! People say you can’t eat gold. Well you sure as heck can’t eat toilet paper. If people need that much, they should buy a darn proctologist.


520 posted on 04/29/2020 10:24:31 PM PDT by PA Engineer (Liberate America from the Occupation Media.)
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