Posted on 01/11/2010 11:19:10 AM PST by decimon
COLLEGE STATION - Mango. If you know little about this fruit, understand this: It's been found to prevent or stop certain colon and breast cancer cells in the lab.
That's according to a new study by Texas AgriLife Research food scientists, who examined the five varieties most common in the U.S.: Kent, Francine, Ataulfo, Tommy/Atkins and Haden.
Though the mango is an ancient fruit heavily consumed in many parts of the world, little has been known about its health aspects. The National Mango Board commissioned a variety of studies with several U.S. researchers to help determine its nutritional value.
"If you look at what people currently perceive as a superfood, people think of high antioxidant capacity, and mango is not quite there," said Dr. Susanne Talcott, who with her husband, Dr. Steve Talcott, conducted the study on cancer cells. "In comparison with antioxidants in blueberry, acai and pomegranate, it's not even close."
But the team checked mango against cancer cells anyway, and found it prevented or stopped cancer growth in certain breast and colon cell lines, Susanne Talcott noted.
"It has about four to five times less antioxidant capacity than an average wine grape, and it still holds up fairly well in anticancer activity. If you look at it from the physiological and nutritional standpoint, taking everything together, it would be a high-ranking super food," she said. "It would be good to include mangoes as part of the regular diet."
The Talcotts tested mango polyphenol extracts in vitro on colon, breast, lung, leukemia and prostate cancers. Polyphenols are natural substances in plants and are associated with a variety of compounds known to promote good health.
Mango showed some impact on lung, leukemia and prostate cancers but was most effective on the most common breast and colon cancers.
"What we found is that not all cell lines are sensitive to the same extent to an anticancer agent," she said. "But the breast and colon cancer lines underwent apotosis, or programmed cell death. Additionally, we found that when we tested normal colon cells side by side with the colon cancer cells, that the mango polyphenolics did not harm the normal cells."
The duo did further tests on the colon cancer lines because a mango contains both small molecules that are readily absorbed and larger molecules that would not be absorbed and thus remain present in a colon.
"We found the normal cells weren't killed, so mango is not expected to be damaging in the body," she said. "That is a general observation for any natural agent, that they target cancer cells and leave the healthy cells alone, in reasonable concentrations at least."
The Talcotts evaluated polyphenolics, and more specifically gallotannins as being the class of bioactive compounds (responsible for preventing or stopping cancer cells). Tannins are polyphenols that are often bitter or drying and found in such common foods as grape seed, wine and tea.
The study found that the cell cycle, which is the division cells go through, was interrupted. This is crucial information, Suzanne Talcott said, because it indicates a possible mechanism for how the cancer cells are prevented or stopped.
"For cells that may be on the verge of mutating or being damaged, mango polyphenolics prevent this kind of damage," she said.
The Talcotts hope to do a small clinical trial with individuals who have increased inflamation in their intestines with a higher risk for cancer.
"From there, if there is any proven efficacy, then we would do a larger trial to see if there is any clinical relevance," she said.
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According to the National Mango Board, based in Winter Park, Fla., most mangoes consumed in the U.S. are produced in Mexico, Ecuador, Peru, Brazil, Guatemala and Haiti. Mangoes are native to southeast Asia and India and are produced in tropical climates. They were introduced to the U.S. in the late 1800s, and a few commercial acres still exist in California and Florida.
Understand this ping.
Now you listen to me...
If true, the drug companies will bottle it and sell at a premium price...available by prescription only
thanks, bfl
Any fruit or other agricultural product effective against high blood pressure?
Are mango sales low?
Don't know.
WARNING!
Mango is a cousin to poison ivy. The pulp is ok but there is a substance in the peel or right beneath the peel that can cause some to break out. Of course, anything in the peel is likely to get onto the pulp so you’re taking your chances if you are allergic.
You would doubt Texas A&M? Tsk tsk.
Garlic tablets
“Mango is a cousin to poison ivy”
Am I fortunate that I have never been near a mango. I spent a whole summer swollen up with Poison Ivy and the Bethesda Maryland Hospital had to give me a series of shots that they said I could never be given again in my life (I was 13 at the time) if I was exposed again. This was in VA. I have lived in the West since then and never go anywhere near parks and woods unless on well defined trails.
Oh no, just wondered. cough, cough
Some hot tea with lemon and honey for that cough. And chicken soup. And vitamin D. And C.
Ouch! I check every fruit drink and mixed fruit before I buy it to make sure it doesn’t contain mangoes. I have always been highly allergic to poison ivy but never knew about mango. Many years ago, before they were common in grocery stores, I ate a fresh mango and my whole face and mouth broke out. The Dr. thought I had some unknown disease. It was b-a-d. Never again.
Her intitial symptoms were diagnosed as gerd...
Just watch out for the effing tigers!
Just curious if anyone even gets that obscure reference.
“Mango peel contains urushiol, the chemical in poison ivy and poison sumac that can cause urushiol-induced contact dermatitis in susceptible people.[28] Cross-reactions between mango contact allergens and urushiol have been observed.[29] Those with a history of poison ivy or poison oak may be most at risk for an allergic reaction to mango skin.[30] This compound is also present in mango leaves and vines. During mango’s primary season, it is the most common source of plant dermatitis in Hawaii.”
http://en.wikipedia.org/wiki/Mango
No way I'm putting a mango in my colon. Those things are HUGE.
And then there's the urushiol. "Doc, I have this funny rash..."
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