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World-first tooth-regrowing drug will be given to humans in September
New Atlas ^ | May 28, 2024 | Bronwyn Thompson

Posted on 05/29/2024 12:49:48 PM PDT by Red Badger

The world's first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030.

The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar. The intravenous treatment will be tested for its efficacy on human dentition, after it successfully grew new teeth in ferret and mouse models with no significant side effects.

"We want to do something to help those who are suffering from tooth loss or absence," said lead researcher Katsu Takahashi, head of dentistry and oral surgery at Kitano Hospital. "While there has been no treatment to date providing a permanent cure, we feel that people's expectations for tooth growth are high."

Following this 11-month first stage, the researchers will then trial the drug on patients aged 2-7 who are missing at least four teeth due to congenital tooth deficiency, which is estimated to affect 1% of people. The team is recruiting for this Phase IIa trial now.

Researchers are then looking at expanding the trial to those with partial edentulism, or people missing one to five permanent teeth due to environmental factors. The incidence of this varies from country to country, but it's estimated around 5% of Americans are missing teeth, with a much higher incidence among older adults.

The medicine itself deactivates the uterine sensitization-associated gene-1 (USAG-1) protein, which suppresses tooth growth. As we reported in 2023, blocking USAG-1's interaction with other proteins encourages bone morphogenetic protein (BMP) signaling, which triggers new bone to generate.

(Excerpt) Read more at newatlas.com ...


TOPICS: Business/Economy; Health/Medicine; History; Military/Veterans
KEYWORDS: antibody; dentistry; gene; helixmakemineadouble; japan; katsutakahashi; kyoto; teeth; usag1
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To: Red Badger

21 posted on 05/29/2024 1:19:27 PM PDT by smokingfrog ( sleep with one eye open (<o> --- )
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To: Red Badger
He looks in my mouth and then he starts to gloat.
He says my teeth are O.K.,
But my gums got to go.
- Alice Cooper
22 posted on 05/29/2024 1:19:54 PM PDT by Sgt_Schultze (When your business model depends on slave labor, you're always going to need more slaves.)
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To: smokingfrog

I think I dated her 50 years ago.....................


23 posted on 05/29/2024 1:20:51 PM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
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To: Red Badger

Are you suggesting it comes from inbreeding?


24 posted on 05/29/2024 1:21:08 PM PDT by 9YearLurker
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To: 9YearLurker

Just sayin’.............🙄


25 posted on 05/29/2024 1:22:35 PM PDT by Red Badger (Homeless veterans camp in the streets while illegals are put up in 5 Star hotels....................)
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To: NorthMountain

26 posted on 05/29/2024 1:23:59 PM PDT by bankwalker (Repeal the 19th ...)
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To: Red Badger

Ladies and gentleman..... start your files.


27 posted on 05/29/2024 1:24:24 PM PDT by LastDayz (A blunt and brazen Texan. I will not be assimilated.)
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To: Red Badger

Just what I need: a new egg tooth.


28 posted on 05/29/2024 1:25:13 PM PDT by Hoosier-Daddy ("Washington, DC. You will never find a more wretched hive of scum and villainy. We must be cautious")
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To: ConservativeMind

It’s a tooth-fer!


29 posted on 05/29/2024 1:26:10 PM PDT by Hoosier-Daddy ("Washington, DC. You will never find a more wretched hive of scum and villainy. We must be cautious")
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To: Red Badger

I guess the meth users have something to legitimately celebrate.


30 posted on 05/29/2024 1:38:05 PM PDT by Delta 21 (If anyone is treasonous, it is those who call me such.)
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To: Red Badger
This paves the way for the medicine to be commercially available as early as 2030.

Doesn't climate change kill us all in 2030?

31 posted on 05/29/2024 1:39:29 PM PDT by 1Old Pro
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To: Red Badger

The birth defects this will cause can’t be fathomed.


32 posted on 05/29/2024 1:50:24 PM PDT by Clean_Sweep
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To: Red Badger

will it grow teeth in places where we didn’t know we had places??


33 posted on 05/29/2024 1:54:11 PM PDT by griffin (When you have to shoot, SHOOT; don't talk. -Tuco)
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To: irish guard

Just wait til one of these 30 guys sprouts a molar in the middle of his forehead
**************************************************
Or you chews their food going in and out.


34 posted on 05/29/2024 1:55:16 PM PDT by chickenlips (Neuter your politicians)
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To: griffin
will it grow teeth in places where we didn’t know we had places??

Honeymooning groom to new bride: "Well, I don't know either, but the d@mn thing bit me!"

35 posted on 05/29/2024 1:56:36 PM PDT by BlueLancer (Think of it as evolution in action. [Oath of Fealty - Pournelle and Niven])
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To: NorthMountain

[I hope it has an off-switch, though.]

“I am the walrus.”


36 posted on 05/29/2024 1:58:58 PM PDT by PLMerite ("They say that we were Cold Warriors. Yes, and a bloody good show, too." - Robert Conquest )
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To: napscoordinator

While, you’re at it, please ask Him if he could rethink coronary artery design.


37 posted on 05/29/2024 2:00:19 PM PDT by Savage Beast (If they'll do it to him, they'll do it to you.)
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To: Red Badger

There’s some snake-oil salesman advertising on YouTube about some magic gunk that will repair gums and regrow teeth.

I am skeptical about this, too.


38 posted on 05/29/2024 2:01:15 PM PDT by PLMerite ("They say that we were Cold Warriors. Yes, and a bloody good show, too." - Robert Conquest )
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To: V_TWIN

And dental implant companies weep.
*************************************************
I suspect Dr Bukk has been using this technology to produce his line of “teef” for a while.

https://www.drbukk.com/shop-all-products/


39 posted on 05/29/2024 2:02:11 PM PDT by chickenlips (Neuter your politicians)
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To: chickenlips

I have something like those around here somewhere.....used to freak people the hell out. Lol!


40 posted on 05/29/2024 2:07:48 PM PDT by V_TWIN (America...so great even the people that hate it refuse to leave!)
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