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Fighting tumors through sugar deprivation (Glioblastoma cure from standard “contrast” agent, 5-ALA)
Medical Xpress / Oslo University Hospital / Cancers ^ | August 22, 2022 | Mantas Grigalavicius et al

Posted on 08/22/2022 7:08:40 PM PDT by ConservativeMind

Brain tumor glioblastoma multiforme (GBM) is a disease for which 30% of adults diagnosed survive one year after diagnosis, and only 3% of patients live longer than five years.

GBM surgery is assisted by the use of fluorescent photosensitiser (PS) drugs. One such PS is Protoporphyrin IX (PpIX), a metadrug of exogenously administered 5-aminolevulinic acid (5-ALA). PpIX can precisely guide GBM resection as its prodrug 5-ALA very specifically accumulates in GBM lesions due to structural and functional differences in the vicinity of the GBM tumors.

Scientists have found that apart from being a photosensitive drug, 5-ALA is also a potent inhibitor of the glycolytic enzyme lactate dehydrogenase (LDH). This is a very important finding since most tumor cells draw energy from glycolysis, or the breakdown of glucose, in contrast to healthy cells. Interrupting the glycolysis in cancer cells can force them to die as they are unable to cover their energy needs from other sources. This is a well-established approach in cancer therapy, and LDH has been identified as a target in many anticancer strategies.

The advantage of 5-ALA as an inhibitor of LDH, and consequently of glycolysis, is that it specifically accumulates in GBM tumors. Hence the disruption of the "sugar" breakdown in GBM cells that can lead to their demise. This development opens avenues for other types of cancer.

Dr. Theodossis Theodossiou said, "The fact that 5-ALA is approved for the detection of malignant gliomas and GBM makes our findings more valuable and easier to apply in the clinic. For detection purposes, 5-ALA is only applied to patients for a few hours, which is not enough to kill the cancer cells by glycolysis disruption. However, prolonged administration for one or several days could lead to surprising, even curative results, in a disease which is currently incurable and lethal."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: brain; cancer; glioblastoma; tooomahhh; tumor
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5-ALA appears to normally be used as a sort of active contrast agent that allows only cancer cells to be identified and destroyed. Strangely, it can completely eliminate glioblastoma, simply by administering it over several days, rather than just enough to show the cancer to surgeons.

There now appears to be a cure for glioblastoma.

1 posted on 08/22/2022 7:08:40 PM PDT by ConservativeMind
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

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2 posted on 08/22/2022 7:09:33 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind
There now appears to be a cure for glioblastoma.

Dear God, let it be so! My daughter is a Radiologic Technologist at a children's hospital, and she's usually the first to see these types of cancers - it's just terrible!

3 posted on 08/22/2022 7:14:46 PM PDT by TonyInOhio (H-O-L-D F-A-S-T)
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To: ConservativeMind

I’ve had a few friends die of gbm. It is a wicked fast cancer. This would be a welcome avenue for treatment.


4 posted on 08/22/2022 7:18:52 PM PDT by CodeToad (No Arm up! They have!)
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To: ConservativeMind

Bill O’Reilly was just talking about a food compass Tufts University came out with. About half an hour ago.

Basically stay away from fast food and sugary drinks, especially soft drinks, sweet tea and the like.


5 posted on 08/22/2022 7:32:17 PM PDT by packagingguy
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To: ConservativeMind

A close passed away from this 12 years ago..in the prime of his life.
A co-worker just passed from this a month ago, 14mos after being diagnosed.
Praying it’s truly a cure 🙏🏻


6 posted on 08/22/2022 7:33:28 PM PDT by rainee (Trump won! )
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To: TonyInOhio

My wife was diagnosed with glioblastoma multiforme WHO Grade IV unmetylated wildtype 14 months ago. The tumor was larger than a jumbo egg. She went through 30 radiation treatments and 72 doses of Temodar chemo. While she was about half way through the radiation treatments I started her on fenbendazole and Tumeric. By October the remaining tumor shrunk over 40%. A few months later the tumor was gone. Her last 4 MRIs are cancer free.

Fenbendazole is supposed to prevent micro tubular cells from processing glucose. The theory is that it staves the cancer stem cells. We will see if it continues to work past the 2 year mark.


7 posted on 08/22/2022 7:35:48 PM PDT by Dutch Boy (The only thing worse than having something taken from you is to have it returned broken. )
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To: Dutch Boy

Congrats


8 posted on 08/22/2022 7:39:38 PM PDT by combat_boots
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To: ConservativeMind

It’s ridiculous that they published this without first trying to cure some dying patients. This is typical of current day medicine.


9 posted on 08/22/2022 7:44:10 PM PDT by devere
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To: packagingguy

Tufts claims that Cheerios is a health food, so I am somewhat doubtful of their secret methodology. Maybe General Foods is their corporate sponsor?


10 posted on 08/22/2022 7:45:52 PM PDT by devere
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To: ConservativeMind

Wonderful news. Prayers.


11 posted on 08/22/2022 7:56:48 PM PDT by Bigg Red (Trump will be sworn in under a shower of confetti made from the tattered remains of the Rat Party.)
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To: Dutch Boy

Good for you and your wife! During a routine chest x-ray while I was in the hospital for a stent, they found a growth in one lung. As soon as I got home I started taking fenbendazole which is a dog wormer PanacurC. In a month when I went for a PET scan and diagnosis, the growth had shrunk to almost nothing. Ivermectin is also used in cancer treatment.


12 posted on 08/22/2022 7:59:53 PM PDT by ryderann
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To: ConservativeMind

Only 2 months too late for my dad.

L


13 posted on 08/22/2022 8:01:24 PM PDT by Lurker (Peaceful coexistence with the Left is not possible. Stop pretending that it is.)
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To: ConservativeMind

Good deal! Positive side effect from administration of dye!


14 posted on 08/22/2022 8:32:41 PM PDT by Pete from Shawnee Mission
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To: ConservativeMind

And yet where is all this technology in fighting cancer? Still using Chemo and Radiation which destroys the good along with the bad. Caner is just Big Business and they Medical Cartels do not really want any real answer or cures, or treatments because it would put a lot of people out of work and depress the profits of Big Pharma.


15 posted on 08/22/2022 8:37:33 PM PDT by Captain Peter Blood
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To: Dutch Boy

Amazing!


16 posted on 08/22/2022 8:43:56 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

My Daughter never ate sugar in her adult life - she was a health food nut. She lasted 18 months before she passed away from a glioblastoma.

We have been hearing about cures for many years, but most procedures are still - operation to remove the tumor, high doses of Radiation and months of Chemo. All with the same results.


17 posted on 08/22/2022 8:50:36 PM PDT by EC Washington
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To: Dutch Boy
"Fenbendazole is supposed to prevent micro tubular cells from processing glucose. The theory is that it staves the cancer stem cells"

if the glucose isn't processed, what becomes of it?

18 posted on 08/22/2022 8:58:27 PM PDT by cherry
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To: EC Washington
so sorry for your loss....

I lost a brother to the covid death protocols and all you do when a dearly loved one dies is ask "what if"?..."what if"?.."what if"?.....

19 posted on 08/22/2022 9:03:47 PM PDT by cherry
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To: Lurker

My Dad died of glioblastoma of the brainstem in 1988.


20 posted on 08/22/2022 9:10:06 PM PDT by chronicles
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