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The pursuit of a cure for Alzheimer's disease is becoming an increasingly competitive and contentious quest with recent years witnessing several important controversies. In July 2022, Science magazine reported that a key 2006 research paper, published in the prestigious journal Nature, which identified a subtype of brain protein called beta-amyloid as the cause of Alzheimer's, may have been based on fabricated data. One year earlier, in June 2021, the US Food and Drug Administration had approved aducanumab, an antibody-targeting beta-amyloid, as a treatment for Alzheimer's, even though the data supporting its use were incomplete and contradictory.

I am starting to think that Kamala Harriss's cognitive health is an issue. She can't complete sentences, is mostly incoherent, and her party/media/campaign are hiding her and treating her as if she is Joe Biden aka a veal calf.

Can you pass me the whatchamacallit? It's right over there next to the thingamajig. Many of us will experience "lethologica", or difficulty finding words, in everyday life. And it usually becomes more prominent with age. Frequent difficulty finding the right word can signal changes in the brain consistent with the early ("preclinical") stages of Alzheimer's disease – before more obvious symptoms emerge. However, a recent study from the University of Toronto suggests that it's the speed of speech, rather than the difficulty in finding words that is a more accurate indicator of brain health in older adults. The researchers asked...

Growing's concerns about President Joe Biden's cognitive capabilities, fuelled by his dreadful debate performance, has prompted CNN to finally call for him to undergo cognitive testing.

Living brain cells wired into organoid-on-a-chip biocomputers can now learn to drive robots, thanks to an open-source intelligent interaction system called MetaBOC. This remarkable project aims to re-home human brain cells in artificial bodies. Biocomputing is one of the most bizarre frontiers in emerging technology, made possible by the fact that our neurons perceive the world and act on it speaking the same language as computers do – electrical signals. Human brain cells, grown in large numbers onto silicon chips, can receive electrical signals from a computer, try to make sense of them, and talk back. More importantly, they can...

The campaign previously said the single best hour of fundraising came immediately after Biden's debate against Trump The re-election campaign for President Biden says it has raised a whopping $27 million since his rocky debate performance against former President Trump. From the day of the debate through Friday evening, the Biden-Harris campaign told Fox News that it had raised $27 million. The updated figure comes after the campaign said on Friday that it raised $14 million in "a sign of strength of our grassroots support" on debate day and the morning after. The campaign also noted Friday that 11 p.m....

A new study suggests that certain drugs commonly used to treat enlarged prostate may also decrease the risk for dementia with Lewy bodies (DLB). This observational finding may seem surprising, but it mirrors previous work that links the drugs to a protective effect in another neurodegenerative condition—Parkinson's disease. The researchers think that a specific side effect of the drugs targets a biological flaw shared by DLB and Parkinson's disease, as well as other neurodegenerative diseases, raising the possibility that they may have broad potential for treating a wide range of neurodegenerative conditions. The researchers used a large database of patient...

By starving tumors of glucose, researchers may have found an innovative way of selectively killing cancer cells while sparing healthy ones.A team of researchers at Ben-Gurion University has unveiled a novel approach to treating brain cancer by targeting the survival mechanisms of tumor cells under glucose starvation. Their findings, published May 14 in Nature Communications, suggest that accelerating the metabolic processes of tumor cells during glucose starvation could cause them to quickly exhaust their energy supplies and die. Research head Prof. Barak Rotblat, along with co-lead researcher Gabriel Leprivier of the Institute of Neuropathology at University Hospital Düsseldorf, discovered that...

A new study suggests that people who take a few common drugs may have a decreased risk of having a bleeding stroke due to a ruptured brain aneurysm. The results do not prove that these drugs reduce the risk of this type of aneurysm; they only show an association. Said Jos Peter Kanning, MSc, "Our current surgical treatments for brain aneurysms have a risk of permanent disability and death that often outweighs the potential benefits, so preventing rupture with a non-invasive drug would be very beneficial." Researchers looked at 4,879 people who had ruptured brain aneurysms, called aneurysmal subarachnoid hemorrhages....

Researchers have identified mechanisms in the brain's hippocampal network that are rescued by ketones. These findings build on previous research showing that ketones can alleviate neurological and cognitive affects. As we age, our brain naturally becomes more insulin resistant. This creates a breakdown in communication between neurons, causing symptoms like changes in mood, cognitive decline, and eventually neurodegeneration. Nathan A. Smith, MS, Ph.D. and fellow researchers studied the mechanisms in the brain that break down when insulin resistance is suddenly present, like in trauma, but before symptoms manifest into chronic conditions, like diabetes or Alzheimer's. "Once neuronal function is lost,...

New research provides insights into how exercise may help to prevent or slow cognitive decline during aging. For the study, investigators assessed the expression of genes in individual cells in the brains of mice. The team found that exercise has a significant impact on gene expression in microglia, the immune cells of the central nervous system that support brain function. Specifically, the group found that exercise reverts the gene expression patterns of aged microglia to patterns seen in young microglia. Treatments that depleted microglia revealed that these cells are required for the stimulatory effects of exercise on the formation of...

It has long been known that a hallmark of Alzheimer's disease, and most other neurodegenerative diseases, is the clumping together of insoluble protein aggregates in the brain. During normal disease-free aging, there is also an accumulation of insoluble proteins. Researchers have recently completed a systematic study in worms that paints an intricate picture of the connections between insoluble proteins in neurodegenerative diseases and aging. Furthermore, the work demonstrated an intervention that could reverse the toxic effects of the aggregates by boosting mitochondrial health. "Our study shows how maintaining healthy mitochondria can combat protein clumping linked to both aging and Alzheimer's,"...

Exercise prompts muscles to release molecular cargo that boosts brain cell function and connection, but the process is not well understood. New research has found that the nerves that tell muscles to move also prompt them to release more of the brain-boosting factors. "The molecules released from the muscle go into the bloodstream and then to the brain." said Hyunjoon Kong. "As we get older, we lose these neurons from the muscle," he said. The researchers compared two muscle tissue models—one with neuron innervation and one without. They found that the innervated muscle produced more molecules that promote brain neuron...

A gray-haired older woman sat motionless with her gaze lowered. In the late stages of dementia, she no longer spoke to others or made eye contact.When Ayako Yonetani started playing the violin, the woman slowly lifted her head.“Her mouth moved, and her eyes brightened as if she heard my music and was trying to follow it,” recounted Ms. Yonetani, a concert artist and professor of violin and viola at the University of Central Florida School of Performing Arts.Those who spent time with the older woman were astonished. “They had never seen her react like this before,” she said. But this...

U.S. — Following the revelation that a deadly parasite was once removed from his skull, political experts were shocked to learn that the dead worm found in Robert F. Kennedy, Jr.'s brain was already polling higher than Joe Biden in 11 states. The latest poll results indicated a large portion of the electorate had abandoned Biden in favor of the deceased parasite that had previously been lodged in RFK Jr.'s brain, leaving the White House scrambling to formulate a strategy to combat the dead worm. "We weren't expecting to see numbers like these," said one high-ranking Biden campaign strategist under...

Prolonged use of certain progestogen hormone drugs is associated with an increased risk of developing a type of brain tumor known as an intracranial meningioma, finds a study. Progestogens are similar to the natural hormone progesterone. Meningiomas are mostly non-cancerous tumors in the layers of tissue (meninges) that cover the brain and spinal cord. Researchers set out to evaluate the real life risk of intracranial meningioma requiring surgery in women associated with use of several progestogens with different routes of administration. They used data from the French national health data system (SNDS) for 18,061 women (average age 58) who underwent...

Fiber is essential for the digestive system. It helps maintain a healthy weight and lowers the risk of diabetes, heart disease and certain cancers. Getting the right amount of fiber, whether through food or drinks, is a great way to relieve constipation. In addition to all that, fiber supplements could improve brain function in older adults, according to a new study. The study followed individuals over the age of 60 for a 12-week period. Results found those who took prebiotic fiber supplements showed a "significant improvement in memory." The study evaluated the gut microbiome and its correlation with both cognitive...

One of the persistent myths about shooting bears in self-defense is a bear’s skull is nearly bulletproof. Bears skulls are not bulletproof. However, bear heads are big. It is easy to miss the brain or spine if you aim at the wrong spot or aim away from the brain because you are afraid the bullet will “bounce off.” This is exacerbated by trophy hunters’ hesitancy to shoot a bear in the head. A powerful shot to the brain cavity will fracture the skull, making measurement for the record books impossible.It is difficult to hit the brain of a bear if...

A study provides compelling evidence for clinical practice to direct efforts toward preventing white matter damage in individuals with hypertension in order to protect against cognitive decline and dementia. Gray matter is where the brain cells exist, whereas white matter constitutes the network of nerve fibers that provides the communication connection between different areas of gray matter. The study, led by Dr. Jing Du, found that compared with gray matter, white matter is more vulnerable to raised blood pressure. "Because gray matter has a greater amount of small blood vessels, and therefore a greater supply of blood compared to white...

Scientists are sounding the alarm over the spread of “zombie deer disease” amid fears it may evolve to infect humans. Late last year, experts confirmed Yellowstone National Park’s first case of the infection — officially known as chronic wasting disease — after a deer carcass found in the Wyoming area of the park tested positive for the highly contagious disease. Now, cases have been reported in deer, elk and moose in 33 states across the US, as well as in Canada, Norway and South Korea. The disease “damages portions of the brain and typically causes progressive loss of body condition,...