Supplemental thiamine as a practical, potential way to prevent Alzheimer's disease from commencing

Alzheimer's Association ^ | 28 July 2021 | Jeffrey Fessel

[onthelookout777]

Alzheimer's Association

Supplemental thiamine [vitamin B-1] as a practical, potential way to prevent Alzheimer's disease from commencing

First published: 28 July 2021

Author: Jeffrey Fessel

“… In brief: it is easier to prevent Alzheimer's than to try to reverse it after it has developed. The data supporting the prophylactic use of thiamine are robust. In order to validate its use, a clinical trial is advocated that would enroll persons aged 65 or older who have evidence of depositions of amyloid or tau in their brains, and randomly assign them to take, for as long as 5 years, either thiamine 100 mgs daily or a matched placebo tablet…”

See detailed article:

https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/trc2.12199

[onthelookout777]

For more general info on thiamine deficiency, see:

Hiding in Plain Sight: Modern Thiamine Deficiency

Authors: Chandler Marrs and Derrick Lonsdale

https://www.mdpi.com/2073-4409/10/10/2595/htm

[onthelookout777]

Sorry, some of my above links don’t work. (This is my first time posting a thread.) I’ll try again:

https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/trc2.12199

https://www.mdpi.com/2073-4409/10/10/2595/htm

[alloysteel]

There are several different forms of thiamine, you know. Which is the most practical formulation for supplemental use?

Inquiring minds want to know.

[avital2]

thanks

[ckilmer]

I have read that alzheimer’s may be considered to be a type 3 diabetes. That its involved with too much sugar in the blood.

If that would be true, thiamine would have some kind of mediating effect on blood sugar—or some other pathway that too much sugar disrupts.

What is the pathway that thiamine is involved with that enables it to mitigate the risk of alzheimer’s?

[NetAddicted]

Guess my former mom-in-law was ahead of the game, eating so nutritionally for years, with lots of vitamins.

[onthelookout777]

“I have read that alzheimer’s may be considered to be a type 3 diabetes. That its involved with too much sugar in the blood.
If that would be true, thiamine would have some kind of mediating effect on blood sugar—or some other pathway that too much sugar disrupts.
What is the pathway that thiamine is involved with that enables it to mitigate the risk of alzheimer’s?”
____________________

Specifically regarding diabetes, here’s a quote from one of the articles:

“For individuals with Type 1 or Type 2 diabetes, plasma thiamine was estimated to be ~76% lower than in non-diabetic controls in one study [35]. In another, frank deficiency was found in 98% of the study population using plasma and urine samples [36]. The mechanisms involve hyperglycemia-driven impaired uptake in the kidneys [37] along with increased clearance [35]”

- Hiding in Plain Sight: Modern Thiamine Deficiency
https://www.mdpi.com/2073-4409/10/10/2595/htm

The other article, the one about thiamine to prevent alzheimer’s, has much more to say about glucose metabolism...

https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/trc2.12199

[disclaimer]

Dr. Eric Berg DC on Youtube

Vitamin B1: Synthetic vs. Natural – Dr.B erg

Top Foods High in Vitamin B1

[Faith65]

Thanks.
BKMK

[tinamina]

I was seeing Thimine being touted as a supplement beneficial in treating thyroid problems in the past couple of days. I wonder if there’s a connection.

[tinamina]

https://thyroidpharmacist.com/articles/thiamine-and-thyroid-fatigue/

[Jane Long]

Thanks for posting.

Pinging CM.

[newfreep]

A quick search did not find a definitive dose level - any suggestions?

My food-based multi-vitamin has 25mg (2000%) of daily requirements.

Also, it appears B-1 can help reduce “brain fog” - any comments appreciated by this seasoned citizen.

Thank God for my life long good health - DNA, healthy diet, 5-6x/week at Fitness club...and avoiding racist noise known as “rap crap”.

[jimwatx]

Benfotiamine is readily available and has improved absorption.

[ConservativeMind]

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20% fewer pings) or “Everything” list.

Thank you, Jane Long, for the heads-up.

[DannyTN]

I already take benfotiamine to help with diabetes. It’s a more bioavailable form than thiamine.

[Nea Wood]

Self-ping for later.

[onthelookout777]

ConservativeMind,

I’ve appreciated your past health-related posts. If you like, feel free to start your own new thread about thiamine/B1 as a possible Alzheimer’s preventative. You can clean up my formatting errors, include better quotes from the main article, and add whatever related info you find helpful. And can you find any definitive info on whether 100 mg thiamine per day (as suggested in the article) is safe to take long-term? Thanks for your help.

[Jane Long]

A quick search did not find a definitive dose level - any suggestions?

---

“100 mg thiamine per day (as suggested in the article)”, per the thread poster. See 18.

[GaltAdonis]

Benfotiamine in a form of thiamine that is both fat soluble
AND water soluble - so that it can get to more of the
places/tissues of your body that can benefit from vitamin B1.
(Or that is my understanding of it, anyway.)

I have been taking it daily for about a month, and it does
seem to somewhat relieve the numbness, tingling and occasional
pain of diabetic type 2 neuropathy in my feet.

Since the topic on this thread was B1 (Thiamine) - I thought I'd add my two cents.

Here is what WebMD says about the stuff -

What Is Benfotiamine?

And here is what The Life Extension Foundation (www.lef.org) says about it in regards to
addressing mental decline -

Benfotiamine intake associated with reduced progression of cognitive decline

I hope someone finds this useful.