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Scientists have achieved a breakthrough in sepsis research. In a study on mice, the researchers demonstrated that vitamin B1 (thiamine pyrophosphate, TPP) restores mitochondrial energy metabolism, drastically reduces lactate production, and increases survival rates in sepsis. Sepsis is the body's runaway reaction to an infection. Instead of only attacking the pathogen, the immune system goes into overdrive and also attacks the body itself, while patients experience an excessive buildup of lactic acid in the blood. In the study, the research team has discovered a simple yet powerful therapeutic approach: a combination of vitamin B1 and glucose. In 2021, the same...

Fatigue is a common and often debilitating companion for people with inflammatory bowel conditions. Now, a study provides insight into why vitamin B1—also known as thiamine—helps some patients regain their energy, while others do not experience the same effect. The study shows, among other things, that patients' response to vitamin B1 depends on gut bacteria, with researchers focusing particularly on a specific "good bug" that seems to play a crucial role. "We know that about half of the fatigued patients benefit from treatment with vitamin B1, but we haven't been able to find anything that distinguishes those who had an...

Cereals regarded as healthy may actually raise your risk of dementia — and it's not because of the sugar. A study published in the journal General Psychiatry found a link between a vitamin in brands such as Cheerios and Shreddies and cognitive decline, which can be a precursor for dementia. Thiamine, or vitamin B1, is also found naturally in whole grains, legumes, liver and salmon, and not getting enough of it has also been linked to health issues. But researchers say for the first time they've discovered a J-shaped curve that indicates consuming too much also has negative consequences.

Alzheimer's Association Supplemental thiamine [vitamin B-1] as a practical, potential way to prevent Alzheimer's disease from commencingFirst published: 28 July 2021 Author: Jeffrey Fessel “… In brief: it is easier to prevent Alzheimer's than to try to reverse it after it has developed. The data supporting the prophylactic use of thiamine are robust. In order to validate its use, a clinical trial is advocated that would enroll persons aged 65 or older who have evidence of depositions of amyloid or tau in their brains, and randomly assign them to take, for as long as 5 years, either thiamine 100 mgs...

Do you experience a weakness all the time or do you sometimes feel a slight dizziness whenever you stand up quickly or change your position quickly? If yes, you could be suffering from a low RBC count but relax! Here is the list of best foods to increase red blood cells in your body. Do you go for a frequent check up every once in a while? A busy life where you strive hard to meet your deadlines and accomplish your daily tasks may bring a lot many changes inside your body So the best measure you can take is...

Abstract Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid and Thiamine (HAT therapy) may reduce organ failure and mortality in patients with sepsis and septic shock. HAT therapy is based on the concept that a combination of readily available, safe and cheap agents, which target multiple components of the host’s response to an infectious agent, will synergistically restore the dysregulated immune...

Doses of vitamin B1 (thiamine) can reverse early kidney disease in people with type 2 diabetes, research shows. The team from Warwick University tested the effect of vitamin B1, which is found in meat, yeast and grain, on 40 patients from Pakistan. The treatment stopped the loss of a key protein in the urine, the journal Diabetologia reports. Charity Diabetes UK called the results "very promising" - but said it was too early for any firm conclusions.