I have read that alzheimer’s may be considered to be a type 3 diabetes. That its involved with too much sugar in the blood.
If that would be true, thiamine would have some kind of mediating effect on blood sugar—or some other pathway that too much sugar disrupts.
What is the pathway that thiamine is involved with that enables it to mitigate the risk of alzheimer’s?
“I have read that alzheimer’s may be considered to be a type 3 diabetes. That its involved with too much sugar in the blood.
If that would be true, thiamine would have some kind of mediating effect on blood sugar—or some other pathway that too much sugar disrupts.
What is the pathway that thiamine is involved with that enables it to mitigate the risk of alzheimer’s?”
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Specifically regarding diabetes, here’s a quote from one of the articles:
“For individuals with Type 1 or Type 2 diabetes, plasma thiamine was estimated to be ~76% lower than in non-diabetic controls in one study [35]. In another, frank deficiency was found in 98% of the study population using plasma and urine samples [36]. The mechanisms involve hyperglycemia-driven impaired uptake in the kidneys [37] along with increased clearance [35]”
- Hiding in Plain Sight: Modern Thiamine Deficiency
https://www.mdpi.com/2073-4409/10/10/2595/htm
The other article, the one about thiamine to prevent alzheimer’s, has much more to say about glucose metabolism...
https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/trc2.12199