Uncovering the mechanism by which calcium deposits accumulate on the walls of arteries
could help develop new treatments for everything from heart disease to dementia
(Credit: Melinda Duer)
Posted on 06/13/2019 7:59:00 AM PDT by Hostage
Uncovering the mechanism by which calcium deposits accumulate on the walls of arteries
could help develop new treatments for everything from heart disease to dementia
(Credit: Melinda Duer)
A landmark study, led by a team of scientists from King's College London and the University of Cambridge, has described the mechanism responsible for the hardening of arteries. The research also points to a common antibiotic as a potential new treatment to prevent this condition.
(Excerpt) Read more at newatlas.com ...
Short synopsis: As cells die, an enzyme, labeled as poly ADP Ribose or PAR, is released. PAR causes calcium to cluster and crystalize leading to plaques and hardening deposits. An already existing approved antibiotic minocycline is known to suppress PAR but unfortunately, its approved dosage levels are thought to be insufficient.
Me: So now we know, via NMR Spectroscopy, what the culprit is and we have a starting point for developing a treatment. My take going forward would be to look at elderly persons who have no symptoms of arteriosclerosis or related plaque hardening deposits, screen them to see if their RNA expression levels for PAR are uniformly low or diverse. If the former, the benefit is likely genetic. If the latter. what are they eating, drinking? Study that.
minocycline
Very interesting indeed. I hope it will result in development of a medicine to prevent hardening of the arteries.
Need to look at that!
Garlic and cayenne pepper, especially eaten in combination, are alleged to clear out clogged arteries.
Might work.
If peoples arteries are so hard why do we need Viagra?................
The only issue I see is the continuous use of any antibiotic can cause other problems such as digestive ailments, suppressed immune system and increased antibiotic resistance. But if they could sort that issue out this could be game changer....
It sounds like PAR is a critical enzyme with some important functions.
How does minocycline suppress PAR?
And a room................
Anyu chemists here?
What is the effect of potassium on calcium?
I had a feeling I was low, so I started taking some.
When you are low, you can’t take the RDA amount, that just keeps you low. So when I start something new I usually take 5 times the amount for a week or two.
I can usually tell if I ‘feel’ any effects that way.
I have to go check, but I think the potassium increase (supplements, bananas, and coconut water) are helping lower my blood pressure- My feet used to feel like they were swollen, but they weren’t looking fat or puffy. That has decreased.
Vitamin D makes you sleep better- and have pleasant dreams - but you MUST take magnesium supplements too or you’ll get cramping.
Magnesium makes your digestive system much better.
Stopping bread cut down on heartburn (A LOT~!) and joint pain (ALSO A LOT~!) if I eat wheat now I can barely walk from the joint pain.
JELLO also helps keep your fingernails good and reduces joint pain.
Now you've gotten to the important issue!
An interesting question:
Very sharp.
The last thing we need is another antibiotic, what utter B.S.
Big Pharma just can’t improve on the fact that God “made herbs for the service of man”...
Cayenne pepper. Every heart patient should have some in his glove box and bedside table. It absolutely clears arteries and strengthens heart muscle.
Yep. Why I would hope diet adjustments suggested in #6 above would be studied. A direct link would be great, one where certain diet adjustments point unequivocally to lower levels for PAR in the bloodstream.
We don’t.
What happened to bad cholesterol?
Exactly-—I never believed the BS “It’s eggs and meats that cause this...”
Interesting yes, but no explanation for why some people get hardened arteries and others don’t.
For decades a daily low dose of aspirin was to be the cure all for heart disease and and many of us took a daily aspirin. Now studies have shown that to be worthless. Needless to say I’m sceptical
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