Short synopsis: As cells die, an enzyme, labeled as poly ADP Ribose or PAR, is released. PAR causes calcium to cluster and crystalize leading to plaques and hardening deposits. An already existing approved antibiotic minocycline is known to suppress PAR but unfortunately, its approved dosage levels are thought to be insufficient.
Me: So now we know, via NMR Spectroscopy, what the culprit is and we have a starting point for developing a treatment. My take going forward would be to look at elderly persons who have no symptoms of arteriosclerosis or related plaque hardening deposits, screen them to see if their RNA expression levels for PAR are uniformly low or diverse. If the former, the benefit is likely genetic. If the latter. what are they eating, drinking? Study that.
minocycline
Very interesting indeed. I hope it will result in development of a medicine to prevent hardening of the arteries.
If peoples arteries are so hard why do we need Viagra?................
The only issue I see is the continuous use of any antibiotic can cause other problems such as digestive ailments, suppressed immune system and increased antibiotic resistance. But if they could sort that issue out this could be game changer....
It sounds like PAR is a critical enzyme with some important functions.
How does minocycline suppress PAR?
Anyu chemists here?
What is the effect of potassium on calcium?
I had a feeling I was low, so I started taking some.
When you are low, you can’t take the RDA amount, that just keeps you low. So when I start something new I usually take 5 times the amount for a week or two.
I can usually tell if I ‘feel’ any effects that way.
I have to go check, but I think the potassium increase (supplements, bananas, and coconut water) are helping lower my blood pressure- My feet used to feel like they were swollen, but they weren’t looking fat or puffy. That has decreased.
Vitamin D makes you sleep better- and have pleasant dreams - but you MUST take magnesium supplements too or you’ll get cramping.
Magnesium makes your digestive system much better.
Stopping bread cut down on heartburn (A LOT~!) and joint pain (ALSO A LOT~!) if I eat wheat now I can barely walk from the joint pain.
JELLO also helps keep your fingernails good and reduces joint pain.
bmk
(Remembering all of the admonitions to NEVER over-use antibiotics)... How many strains of how many germs will now become even more drug-resistant?
Beware of the Pharmo- government complex
Good health this primarily determined by two things
1- diet.
2- excercise
With just these two items you can pretty much cover your own health and I would be very very wary about ever taking any little pill that the government - medical complex tells you to take other than maybe an aspirin
Why ? Unintended consequences
Vitamin K2 cleans the calcium up.
Vascepa, by Amarin. FDA Approved for high trigs. Come Sept nearly a slam dunk for expanded label as Reduce-it Phase III trials shows 30% reduction in strokes, 26% reduction in cardiac events and 20% reduction in deaths vs placebo. (Both groups were on statin). The ADA has made the active ingredient in Vascepa ( icosapent ethyl) standard of care for high risk diabetics for 2019.
Also come Sept. a third party study of Vascepa will issue results from the Evaporate study. = Proving reduction in arterial plaque.
The mechanism for Vescepa’s effacy has been a bit of a head scratcher other than significant reduction in inflammation. I believe the plaque reduction result will be proven as well. Due your own DD but current share price is cheap. Amarin has this drug locked up in Patents for the next ten years. Highly likely Big Pharma will come calling with a significant offer once expanded label is approved. Full disclosure as if it isn’t obvious I own a couple thousand shares. And no I don’t have any affiliation with said company.
I hope this leads to new successes in treatment, but also hope this research team looks into non-antibiotic treatment as well as prevention of this, now that they better understand the mechanism.
Bookmark
Interesting, an antibiotic. I would have thought an anti-inflammatory.
5.56mm
Bttt
Idiopathic intracranial hypertension
Minocycline is known as an anti-inflammatory derivative of the Tetracycline antibiotic family. It was evaluated in clinical trials for treatment of Rheumatoid Arthritis, though now there are more effective drug treatments with fewer side effects available. It’s effectiveness was not attributed to combating any kind of underlying infection as a causative of the RA.
BookMarking!
Or you can just take K2.