Free Republic

Abstract Here, we propose a new strategy for the treatment of early cancerous lesions and advanced metastatic disease, via the selective targeting of cancer stem cells (CSCs), a.k.a., tumor-initiating cells (TICs). We searched for a global phenotypic characteristic that was highly conserved among cancer stem cells, across multiple tumor types, to provide a mutation-independent approach to cancer therapy. This would allow us to target cancer stem cells, effectively treating cancer as a single disease of “stemness”, independently of the tumor tissue type. Using this approach, we identified a conserved phenotypic weak point – a strict dependence on mitochondrial biogenesis for...

Impressionists, cartoonists, and even historians rely heavily on identifying and amplifying the physical and verbal idiosyncrasies of public figures, especially presidents. Their constant presence in the media means that their pet phrases and mannerisms become familiar to all (even against our will) as the inevitable caricatures demonstrate. There was Reagan's "Well..." and a shrug of the shoulders, GHWB41's slow-motion karate chops on the top of the lectern, Clinton's raised index finger, etc. Obama is a special case, however, as he rarely has anything to say of substance (or truth, if you like) beyond the verbal window dressing. His "Let me...