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Pfizer (PFE) CEO Albert Bourla is betting big on repeating the success of its COVID-19 vaccine with an experimental oral treatment — and he's putting the company's money where its mouth is. Bourla told Yahoo Finance Wednesday the company is committing $1 billion to develop the oral treatment — a protease inhibitor — which would give the world an easy-to-use, targeted treatment, hopefully by year's end. The current market for COVID-19 treatments includes monoclonal antibodies and some repurposed drugs, including generics and Gilead Sciences' (GILD) Veklury (formerly Remdesivir) - all of which require being in a hospital or clinic to...

IvermectinI've been watching Bret Weinstein's interview with Dr. Pierre Kory (M.D.) on the alleged suppression of Ivermectin as a therapeutic for COVID-19. The claim is that a meta-analysis of Ivermectin studies -- none of which are the highest quality study -- show an obvious and huge benefit to using the drug. Put another way, the "signal" that the drug works is so strong that it is obvious in any kind of study no matter the quality. And when you consider all the studies together (meta-analysis), the effectiveness of the drug is nearly beyond doubt. So why aren't we using it...

NeuroRx Announces ZYESAMI™ (aviptadil, RLF-100) Met the Primary Endpoint of Its Phase 2b/3 Clinical Trial and Also Demonstrated a Meaningful Benefit in Survival from Critical COVID-19 RADNOR, Pa., March 29, 2021 /PRNewswire/ -- NeuroRx, Inc. today reports 60-day results of the Phase 2b/3 trial of intravenously-administered ZYESAMI™ (aviptadil acetate) for the treatment of respiratory failure in critically-ill patients with COVID-19, which is being developed in collaboration with Relief Therapeutics Holding AG (SIX:RLF,OTCQB:RLFTF). Across all patients and sites, ZYESAMI™ met the primary endpoint for successful recovery from respiratory failure at days 28 (P = .014) and 60 (P = .013) and...

New neurons (seen here in green) can be generated in the hippocampus, a brain region involved in learning and memory. In the study, the use of focused ultrasound enhanced the delivery IVIg to the hippocampus and promoted neurogenesis. Credit: Kate Noseworthy and Dr. Rikke Hahn Kofoed =============================================================== A recent preclinical study from scientists at Sunnybrook Research Institute, Canadian Blood Services and the University of Toronto has demonstrated that focused ultrasound improves the delivery of intravenous immunoglobulin (IVIg), a blood product composed of antibodies from healthy donors, previously shown to have potential in treating a subgroup of patients with Alzheimer's disease....

New Drug Promises “Rapid Recovery From Respiratory Failure”“Overall, 81% of RLF-100™-treated patients survived beyond 60 days, compared to 17% of control patients.” Oct 13, 2020 GENEVA and RADNOR, Pa., Oct. 13, 2020 /PRNewswire/ – RELIEF THERAPEUTICS Holding AG and NeuroRx, Inc., today announced topline results from 45 patients assessed in an open-label prospective study where 21 patients admitted to an intensive care unit (ICU) with critical COVID-19 and respiratory failure were treated with RLF-100™(aviptadil) and compared to 24 control patients treated in the same setting. All patients had severe comorbidities that rendered them ineligible for the ongoing randomized controlled phase...

FDA Lets NeuroRx, Relief Therapeutics Test RLF-100 in COVID-19 PatientsZURICH — The U.S. Food and Drug Administration has granted NeuroRx Inc Investigational New Drug (IND) permission to test RLF-100 (aviptadil) for inhaled use in patients with moderate and severe COVID-19 to prevent progression to respiratory failure, it and partner Relief Therapeutics Holdings said on Thursday. ... They said aviptadil is shown as the first COVID therapeutic to block replication of the SARS-CoV-2 virus in human lung cells and monocytes while also preventing synthesis of cytokines in the lung. ... has been granted FDA fast track designation, FDA emergency use IND...

NeuroRx and Relief Therapeutics Announce Fast Track Designation Granted by the FDA to RLF-100 (Aviptadil) for the Treatment of Respiratory Distress in COVID-19 Fast Track Designation of RLF-100 for the treatment of Acute Lung Injury/Acute Respiratory Distress Syndrome associated with COVID-19 underscores the urgent need for new treatment options for these patients. At FDA's request, NeuroRx is submitting an expanded access policy enabling physicians to request RLF-100 for patients who meet this criterion. June 24, 2020 01:30 AM Eastern Daylight Time RADNOR, Pa. & GENEVA--(BUSINESS WIRE)--NeuroRx, Inc. (OTC:RLFTF), in partnership with RELIEF THERAPEUTICS Holding AG (SIX:RLF) “Relief” today announced that...

Conservative writer/filmmaker Dinesh D’Souza was spared prison time today when a federal judge sentenced him to five years probation for violating campaign finance laws....

SAN DIEGO, Oct. 1, 2008 – More than 50 recently wounded veterans, including troops being processed through the disability evaluation system, are experiencing the healing power of recreation here through the first National Veterans Summer Sports Clinic Pilot Program. Marine Cpl. Sherman Watson (left), who suffered a traumatic brain injury in Iraq, and Eric McDaniel Jr., a former Army sergeant who suffered a stroke in training at Fort Bragg, N.C., participate in track and field events during the National Veterans Summer Sports Clinic in San Diego. Department of Veterans Affairs photo by Gene Davies  (Click photo for screen-resolution image);high-resolution image...

Cardinal Denounces Proposal to Legalize Abortion in the Dominican Republic Says Supporters of the Measure Are Either "Sick", "Hypocritical", or "Comedians" By Matthew Cullinan Hoffman DOMINICAN REPUBLIC, September 10, 2007 (LifeSiteNews.com)--The Cardinal Archbishop of Santo Domingo, in the Dominican Republic, lashed out last week at politicians and groups agitating to legalize abortion in the country. When asked  about a recent proposal to legalize abortion for "therapeutic" purposes, he shot back: "No, no abortion, there is nothing more to say." "No one has the right to kill anyone and some of us are sick, some are hypocrites, some comedians who are...

The noted sociologist Philip Rieff died in 2006, leaving behind a series of works that offer highly original insights into the general state both of modern culture and of religion. Although he said little about liturgy as such, his theories provide an enlightening way of understanding the liturgical crisis. . . . The Three “Cultures” Rieff’s theory of history broadly identified three successive cultures, each of which had some kind of moral idea at its heart. The First (primitive) Culture regarded law merely as “taboo” — fear of magical forces in the universe. The Second Culture, beginning with the ancient...

Riding horses is part of the wild west charm of Southern Arizona. But, for some local veterans, it's a way to get back in the saddle of life. It's been a long, hard ride for retired Navy Airman, Rene Suarez. "I have arthritis in every joint in my body pretty much." This time last year, he needed a cane just to walk. Now, thanks to weekly visits to Therapeutic Riding of Tucson, he no longer needs that cane. Rene credits rides on Bisbee (the horse) for helping him gain strength, by stretching his legs and using muscles he wouldn't normally...

Having vanquished Nazism and Communism, we are now challenged by a totalitarian, anti-semitic ideology disguised as a religion -- Islamo-Fascism. The principles required for victory are no different than in any war: impose our will on our enemies by force of arms. But those enemies, sensing our superior battlefield strength, realize that our vulnerability lies not in our military capability, but elsewhere, in our highly civilized reluctance to use overwhelming force against our foes. Over the years, especially since the Vietnam war, adversaries have learned target our soft home-front underbelly -- the mainstream media (MSM) and the opinion-shaping academic wordsmith...

Last year, researchers at South Korea ’s Seoul National University became the first scientists to successfully clone a single human embryo. And just days ago, the team in Seoul raised the stakes again. They announced that they had found a way to clone embryos in bigger batches: eleven this time, possibly more in the future. But instead of being chilled by the prospect of producing people on a kind of assembly line, many of our leaders have decided to throw all moral caution to the wind. As soon as lead researcher Hwang Woo-suk announced the results, many in the media...

For some, the diagnosis comes out of the blue. For others, it arrives after a long battle. Either way, the news that death is just a few months away poses a daunting challenge for both doctor and patient. Drugs can ease pain and reduce anxiety, but what about the more profound issues that come with impending death? The wish to resolve lingering conflicts with family members. The longing to know, before it's too late, what it means to love, or what it meant to live. There is no medicine to address such dis-ease. Or is there? This month, in a...

SAN FRANCISCO (Reuters) - California is moving quickly to launch a $3 billion stem cell research program approved by voters this month even as the United States is leading a campaign at the United Nations (news - web sites) to ban all cloning of human embryos, including for stem cell studies. California's proposition 71, approved in the Nov. 2 election, calls for the state to fund $300 million a year in stem-cell research over 10 years. Last week the state began appointing members of an oversight panel and it has started evaluating plans for new labs and research sites. Researchers...

The most controversial aspects of Proposition 71 will have strict oversight, experts speaking at a Stanford University forum said Tuesday. A procedure called nuclear transfer, or therapeutic cloning, is central to research on stem cells. Because it involves the creation and destruction of embryos to study diseases and cures, ``it may offend some people,'' said Paul Berg, professor emeritus of molecular and genetic medicine at Stanford and a 1980 Nobel Prize winner. ---snip--- Berg said therapeutic cloning -- in which stem cells are harvested from a cloned embryo -- provides greater scientific opportunities than other methods of obtaining stem cells....

Hatch Is Urged to Back Cloning Ban Wednesday, March 6, 2002 BY DAWN HOUSE THE SALT LAKE TRIBUNE A second pro-life group is targeting Utah Sen. Orrin Hatch to pressure him to support a bill that would ban cloning human embryos for medical research. American Renewal, the lobbying arm of the faith-based Family Research Council, has mailed bright yellow postcards to thousands of Utah homes, charging that Hatch supports efforts to clone human beings to be quot;killed in medical experimentation.quot; But Hatch spokesman Chris Rosche said Utah's senior senator has taken no position on a bill to ban cloning, which...