Research shows that most cases of type 2 diabetes can be prevented through lifestyle interventions. But if you already have the condition, can it be reversed? The answer is a resounding yes, according to Gerald I. Shulman, MD, Ph.D. Insulin resistance drives type 2 diabetes, Shulman explains. "If you reverse insulin resistance, you reverse type 2 diabetes," he said. In a landmark study, Shulman and Kitt Petersen, MD showed that modest weight reduction—even as little as 10%—does just that. However, Shulman notes, many people who are initially successful at losing weight regain it. The novel anti-obesity GLP-1 medications can play...