Smallpox: The Triumph over the Most Terrible of the Ministers of Death Smallpox has been one of humankind's greatest scourges since time immemorial. Even illnesses as terrible as the plague, cholera, and yellow fever have not had such a universal and persistent impact. Smallpox is believed to have appeared at the time of the first agricultural settlements in northeastern Africa, around 10 000 BC (2). It probably spread from Africa to India by means of Egyptian merchants in the last millennium BC (3). The earliest evidence of skin lesions resembling those of smallpox is found on the faces of mummies...