Women ages 45 years and older taking estrogen hormone therapy in pill form were more likely to develop high blood pressure than those using transdermal (topical, applied to the skin) or vaginal formulations, according to research. "We know estrogens ingested orally are metabolized through the liver and this can lead to higher blood pressure," said Cindy Kalenga, an M.D./Ph.D.-candidate This study involved a large group of over 112,000 women, ages 45 years and older. First, researchers investigated the relationship between route of estrogen-only hormone therapy administration and risk of developing high blood pressure at least one year after starting the...