Polyethylene glycol (PEG) or macrogol is a polyether compound. It is widely used as an additive in pharmaceuticals, cosmetics and food [1]. Different types of macrogol exist according to their molecular weight from 300 g/mol to 10,000,000 g/mol [2]. Anaphylactic reactions to macrogol are rarely reported. However, in recent years more reports appeared in the literature with macrogol induced hypersensitivities due to drugs, personal hygiene products, dental products, lozenges and lubricants [3, 4]. Here we report on a female with a history of three immediate type reactions triggered by macrogol 3350.