In A Nutshell * Two FDA-approved cancer drugs — letrozole and irinotecan — significantly improved memory and reduced brain damage in mice with Alzheimer’s. * The combination therapy targets multiple brain cell types by reversing gene disruptions in neurons and glia. *Real-world medical records of 1.4 million patients show lower Alzheimer’s rates in people treated with these drugs for cancer. * The findings offer a new multi-target strategy that may outperform existing single-drug treatments, but human trials are still needed. SAN FRANCISCO — Two cancer medications already on pharmacy shelves might hold the key to treating Alzheimer’s disease, and early...