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Decline in the hypothalamic Menin may play a key role in aging, according to a study. The findings reveal a previously unknown driver of physiological aging, and suggest that supplementation with a simple amino acid may mitigate some age-related changes. Leng and colleagues showed that Menin, a hypothalamic protein, is a key inhibitor of hypothalamic neuroinflammation. They observed that the level of Menin in the hypothalamus, but not astrocytes or microglia, declines with age. Another change was a decline in levels of the amino acid D-serine, known to be a neurotransmitter and sometimes used as a dietary supplement. The authors...

Nutrition, Metabolism & Cardiovascular Diseases — Lima A, Ferin R, Fontes A, et al.This study was intended to assess whether cysteine is a better prognosticator of coronary artery disease than conventional homocysteine in high-risk subjects under preventive medication. Researchers enrolled a total of 174 individuals with symptomatic coronary artery disease (CAD) (age 56±9y; 68% men) who submitted to coronary angiography were split into 2 groups: one formed by CAD patients (≥50% stenosis in at least one major coronary vessel) and the other by non-CAD patients (<50% stenosis). Via RP-HPLC/FLD, Plasma and erythrocyte aminothiol profiles were assessed. Compared with non-CAD group,...