Reduced levels of coenzyme A (CoA) worsen heart failure and likely help exacerbate cardiac dysfunction during heart failure, according to a new study. In addition, the findings suggest certain metabolic pathways may be disproportionately affected by reduced CoA levels. CoA is a critical molecule in the metabolism. Fluctuations in the amount of the enzyme are often observed in foundational development of many diseases, such as cancer and diabetes. Prior to this study, the link between CoA levels and heart failure had not been investigated. Using mice that lacked a specific enzyme for CoA production, physiologists at the Diabetes and Obesity...