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Keyword: cellmutation

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  • Breast cancer-fighting gene's job made more difficult by obesity

    02/28/2023 9:16:01 PM PST · by ConservativeMind · 2 replies
    Medical Xpress / Science Translational Medicine ^ | Feb. 27, 2023 | Justin Jackson / Priya Bhardwaj et al
    A new study has found that in women with BRCA gene mutations, having a high body mass index (BMI) is linked to more DNA damage in breast cells. Specifically, the study discovered that elevated BMI was associated with more damage to epithelium tissue DNA. Priya Bhardwaj, Ph.D. Candidate and her team worked with cultured healthy breast tissues collected from individuals with mutated BRCA1 and BRCA2 genes. The samples were categorized as coming from a donor of lower weight (BMI < 25 kg/m2, n = 43) or overweight/obese (BMI ≥ 25.0 kg/m2, n = 26). BRCA1 and BRCA2 genes are protecting...