Scientists are working to understand how aging itself can be modified to prevent age-related diseases, including Alzheimer's disease. A new study has discovered that calcium alpha-ketoglutarate (CaAKG), a safe, naturally occurring metabolite commonly studied for healthy aging, can restore key memory-related brain functions that have been disrupted in Alzheimer's disease. The main aim of the study was to evaluate whether CaAKG could also enhance synaptic plasticity in the Alzheimer's brain, restore memory-related signaling, protect neurons from early degenerative changes, and contribute to healthier cognitive aging. The study shows that CaAKG helps brain cells communicate better in Alzheimer's disease models. It...