Posted on 01/17/2014 6:10:07 AM PST by Innovative
Acetaminophen is often used in pain medications with opioids such as oxycodone (Percocet), hydrocodone (Vicodin) and codeine (Tylenol with Codeine). These are called combination drugs, and the Food and Drug Administration is asking doctors to stop prescribing those that have more than 325 mg of acetaminophen per dose.
Acetaminophen overdose is one of the most common poisonings worldwide," according to the National Institutes of Health.
Taking too much of this pain reliever can lead to liver failure or death.
n 2011, the FDA asked manufacturers to limit the amount of acetaminophen in prescription combination drugs to 325 mg per capsule or tablet by January 2014. While more than half of the manufacturers agreed, some combination drugs with higher amounts of acetaminophen remain on the market.
To find out if your medications contain acetaminophen, read the drug label or the list of ingredients in the patient information leaflet that came with your prescription. Look for the word "acetaminophen" or the letters "APAP," an abbreviation sometimes used for the drug. If you are still unsure, contact your doctor or pharmacist.
(Excerpt) Read more at cnn.com ...
I think it has been known for a long time that acetaminophens can cause liver damage -- this is addressed now because the FDA rule of not having combination drugs with more than 325 mg of acetaminophen became effective Jan 2014.
MIGHT
Running with scissors MIGHT also be dangerous.
I’m sure the pharmaceutical companies will use this and find a way to get cheap competition over the counter drugs off the market. Why not? If everyone’s insured, why shouldn’t people pay more for safety? (sarcasm)
?
The recommended dosage on my bottle of Extra-Strength pills recommends 1 x 500mg.
How can one get NyQuil without the Ace- Aceeetomino -
Without the Tylenol?
Thus the Feds need to remove the most popular non-prescription pain killer from our shelves and regulate it.
Thus the Feds need to remove the most popular non-prescription pain killer from our shelves and regulate it.
Its not the dose its the 24 hour total that is the problem. A single dose of 650-1000 mg is fine. But one shouldn’t exceed 4000 mg daily in the short term and prob 3000 mg daily in the long term or liver damage may result.
Tylenol causes liver damage...
NSAIDs like advil/aleve raise blood pressures
I went back to taking good old fashioned miracle drug aspirin for my general aches and pains.
And yes, it bugs me that Tylenol is often included in many OTC drugs too, like...Nyquil.
Better to murder a druggie via liver failure than let him abuse Rx drugs, eh?
Ah well, the precedent was set with the requirement to poison, "denature", perfectly drinkable alcohol.
Better to have a million alkys (or naïve teenagers) go blind or die than miss a couple tax dollars, I suppose...
My mom has been popping Excedrins like candy for decades now. Don’t know how her liver is, but she is fine, so it is probably too. Still, I personally am very careful with the stuff.
Isn't Excedrin aspirin, not acetaminophen?
I just popped 2x 250mg pills before reading this. So total dose of 500mg.
But see the prev post about max daily dose. The situation here is apparantly that substantial doses are being “snuck” into peoples systems via combo drugs, quickly exceeding the daily limits without the person realizing it.
Not that kind of might. It would appear that this is the T-50, where for 50% of the people this dosage proves to be at least slightly toxic. So it’s “might” in that you MIGHT be part of the 50% that doesn’t get damaged until a higher dose (how much higher of course varies throughout the group, could be just 1 more mg for you), but you also MIGHT be part of the 50% damaged here, you MIGHT even be in a group being damaged by a lower dose.
We’ve known for a long time acetaminophen is rough on the liver, this is just ranging in on the danger line.
**** where people may not even be aware that they contain acetaminophen. ****
TRUE! It is in too many over the counter drugs. We have to read labels closely, and sometimes special order the OCT version with asprin.
They did the same with OTC asthma inhalers. Now we have to go the doctor and get refills and the albuterol ones don’t seem to last as long as the old Primatenes did. Yes I know epinephrine is bad in high/prolonged doses but a better rescue inhaler there is not.
Exactly right...My MIL has arthritis and broke a hip over ten years ago, she takes 650 mg doses 5 times a day, her doctors over the years have said exactly what you’ve posted.
The only thing is that my wife is careful not to buy any other meds she may need temporarily that contain Acetaminophen and there are many many that do.
An overdose of acetaminophen can cause depletion of glutathione and land a person in the hospital. The current treatment for acetaminophen overdose relies on a compound that replenishes the glutathione in the liver. This treatment is effective, provided it is given in time.
Perhaps they should add glutathione to acetaminophen pills.
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I just took 1 1/2 Excedrin. Otherwise, I'll have a migraine all day.
I do this from time to time on account of the sinus migraines. I'll take 1 or 1 and 1/2 but don't go up to two because the caffeine runs blood pressure up.
People react differently to the same drug but there are general cautions to be mindful of.
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