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Posted on 08/07/2025 12:34:30 PM PDT by Red Badger
It looks likely we'll see oral GLP-1 drugs on the market by next year, with pharmaceutical company Eli Lilly reporting impressive results following a large, robust 72-week trial that saw obese participants lose an average of 27.3 lb, or 12.4% of their body weight with the once-daily pill.
This week the company announced positive results from its Phase 3 ATTAIN-1 trial of the GLP-1 receptor agonist known as orforglipron, given to 3,127 adults with obesity over 72 weeks. In the long study, all doses passed their efficacy and tolerability benchmarks compared to a placebo, with clinically significant results across the board.
Now, the US drug maker is set to apply for global approval of orforglipron by the end of 2025, meaning it's likely to be the first oral weight-loss drug in this class and likely to be on offer in the new year.
"Obesity is one of the most pressing global health challenges of our time, driving global chronic disease burden and impacting more than one billion people worldwide," said Kenneth Custer, executive vice president and president of Lilly Cardiometabolic Health. "With orforglipron, we're working to transform obesity care by introducing a potential once-daily oral therapy that could support early intervention and long-term disease management, while offering a convenient alternative to injectable treatments."
"With these positive data in hand, we are now planning to submit orforglipron for regulatory review by year-end and are prepared for a global launch to address this urgent public health need," he added.
Trial participants on the highest dose lost an average of 27.3 lb (12.4%) at 72 weeks, and 59.6% of participants on this dose lost at least 10% of their body weight. What's more, 39.6% lost at least 15% of their body weight. Orforglipron also significantly lowered cardiovascular disease risk, including non-HDL cholesterol, triglycerides...
(Excerpt) Read more at newatlas.com ...
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This treatment can’t be good. I lost 48 last year just by light exercise, eating three times and day, cutting out alcohol, sweets, and drinking water throughout the day.
great, now we will see even more walking corpses walking around.
GLP’s make people look AWFUL
Price.
Same here. From 212 to 155. About 2 years.
Are you men?
I don’t know about cutting out drinking water.
I know a man who lost 60+ pounds by cutting out soda, junk food, and fast food, and he went to the gym with a personal trainer once a week.
He says now his tastes have changed and when he was out recently and needed to eat stopped at a McD’s (IIRC) and ordered his previous favorite meal and could hardly choke it down. But he did as he was hungry and he said he spent to much to throw it out. And never again.
I lost 170 pounds in 2 years. Not using drugs, just intermittent fasting and watching what I eat.
Maybe some people should just stop eating so much.
You guys are impressive. My husband can lose weight without trying. Drives me batty.
My weight has yo-yo’d so all the hard work just gets depressing when it gets undone from year to year. My doctor put me on Rybelsus - one pill per day - for diabetes, as I refused insulin, and I was shocked to find myself losing weight. Told her and got laughed at. Lost 40 lbs and have been complimented frequently. Totally joyful. And all of my medical numbers have rapidly moved into great ranges. Healthier than I can remember being in years. Energy, clear mind and restarting projects I let lapse for years. Mentally, I’ve lost 40 years beside the pounds. Back to blue jeans.
Husband, also diabetic, was green with envy and the doctor put him on it also. We’re working hard to make sure he DOESN’T lose weight. But all of his numbers are now moving in the right direction, too. He takes no insulin and I’m thrilled.
I seem to be one of those people who gain five pounds just seeing a McDonalds commercial.
My hubby is the same and it also drives me insane. I have the metabolism of a slug, OTOH, and I’ve struggled with my weight since I was a teenager. I’m 5 feet tall and weigh ~140, which is huge for me. I don’t binge eat, rarely snack, avoid junk food, and only eat 2 meals a day, yet the scale barely budges. Intermittent fasting and keto didn’t work for me, so I’m going back to the old fashioned method of increasing my activity level. I’ll be 72 soon and losing weight has been much harder since I turned 65. 😖
If someone could turn sweet tea into a weight-reduction tonic, I’d be as skinny as a 2x4.
You can buy them off of Amazon BUT I would not recommend trying until you talk to your doctor, but you can buy glucose meters. I’m on week 3 and the insights to food on my glucose level is staggering. I’m leveled off now by following Atkins.
I ate a package of peanut butter crackers you get in a vending machine & my glucose spiked to 225+ I told my wife that it gave me insight into previous behavior where I had a burger & fries and then dessert. If a package of crackers can make it spike, imagine the burger, fries etc. is doing to you!!
“orforglipron”
Great name!!
—> “Oh, for girl porn”
I’m 81 so I know what you mean. I was in my 40’s when I got so upset about being hit on that I purposely gained weight. STUPID! Never thought how tough it would be to take it off as it was so very easy to put it on. This diabetes medicine is the first time I’ve been able to have any control over weight loss. I’m on it for life and just grateful so much is covered by insurance.
I hear you.
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