Posted on 07/19/2024 5:16:41 AM PDT by Red Badger
Opioids, like morphine, are effective painkillers but have led to widespread addiction and serious side effects like respiratory depression, notably seen in the U.S. opioid crisis that claimed nearly 645,000 lives from 1999 to 2021. Researchers at Johannes Gutenberg University Mainz have identified a potential alternative, aniquinazolin B, from the marine fungus Aspergillus nidulans, which binds to opioid receptors and could replace opioids with fewer undesirable effects, after rigorous testing including over 750,000 calculations per substance using the MOGON supercomputer.
Researchers at Mainz University have discovered a natural compound that could potentially serve as a long-term alternative to opioids and may help alleviate the opioid crisis. Opioids, recognized for their significant pharmacological effects, have long been used as effective painkillers. Morphine, a notable example first isolated and synthesized in the early 19th century, provides crucial relief for patients in the final stages of severe illness.
However, when opioids are used inappropriately they can cause addiction and even the development of extremely serious undesirable effects, such as respiratory depression. In the USA, opioids were once widely promoted through the media and, as a consequence, were often prescribed to treat what were in fact mild disorders. According to the Centers for Disease Control and Prevention (CDC), there were nearly 645,000 cases of mortality due to opioid overdose in the United States between 1999 and 2021.
And the opioid crisis has arrived in Germany, too. The main problem is street drugs and the fact that the synthetic opioid heroin, in particular, is cut with other, cheaper opioids, such as fentanyl. While a dose of 200 milligrams of heroin is fatal, just two milligrams of fentanyl can kill. In 2022, more than 1,000 people in Germany died as a result of the consumption of opioids.
Starting with a database of 40,000 natural substances Governments have introduced measures to contain this epidemic. However, opioid addiction rates are high. Others suffer from extreme pain that needs to be alleviated. There is thus an urgent need for safe analgesics. Researchers at Johannes Gutenberg University Mainz (JGU) – with the financial support of the Research Training Group “Life Sciences – Life Writing”, funded by the German Research Foundation (DFG) – have now made progress towards this goal.
“A natural product called aniquinazolin B that is isolated from the marine fungus Aspergillus nidulans stimulates the opioid receptors and could possibly thus be used instead of opioids in the future,” explained Roxana Damiescu, a member of the research team headed by Professor Thomas Efferth.
Presentation of the binding of aniquinazoline B to an opioid receptor. Credit: Mohamed Elbadawi / JGU
In the search for new compounds, the team started with a chemical database of more than 40,000 natural substances. It was their aim to determine how effectively each substance would bind to the corresponding receptor. And, in addition, they had to ascertain whether these had the properties required of a pharmaceutical drug.
Such a compound must be water-soluble to some extent, for example. This research required calculations in the form of approximations, with the results becoming increasingly more precise the more frequently these calculations were performed. Each substance was the subject of some 750,000 individual calculations. Such a colossal number of calculations would vastly exceed the capacity of a standard PC. Therefore, the team utilized the MOGON supercomputer at JGU. The top 100 candidate products of these calculations were subsequently assessed using other analytical methods.
Further detailed investigation in the lab The resultant top ten found their way into the lab, where they underwent biochemical analysis. The initial priority was to establish safety. Using preparations of human kidney cells, the researchers looked at whether higher concentrations of each substance would prove toxic to the cells and even kill them. Finally, two other aspects had to be subjected to testing.
“We needed to confirm that the high binding energy of the substances to the pain receptors that had been predicted by the theoretical calculations was actually also produced in the real physical world,” said Professor Thomas Efferth, head of the JGU Department of Pharmaceutical Biology. However, binding of a substance to the receptors is not alone sufficient. The binding must also influence the functioning of the receptors.
Thus, the research team used a second test system to assess whether there was the kind of inhibition of biological activity that occurs during opioid use. One of the two compounds passed all tests with flying colors: aniquinazolin B, the substance present in the marine fungus Aspergillus nidulans. “The results of our investigations indicate that this substance may have effects similar to those of opioids. At the same time, it causes far fewer undesirable reactions,” concluded Roxana Damiescu.
Reference:
“Aniquinazoline B, a Fungal Natural Product, Activates the μ-Opioid Receptor” by Roxana Damiescu, Mohamed Elbadawi, Mona Dawood, Sabine M. Klauck, Gerhard Bringmann and Thomas Efferth, 23 May 2024, ChemMedChem.
DOI: 10.1002/cmdc.202400213
Soon to be bought up and price goes up exponentially by Big Pharma.
One wonders about the ubiquity of this fungus, how readily it can be replicated, and how easy it is to isolate the active.
They are modeling.
Computers models are not the real world, they are an imperfect simulacra of the real world.
When opioid receptors are blocked the cells immediately produce more receptors. This is key to addiction. The more receptors the more receptor blockers required. Did I miss how this self-defeating pain problem is addressed by the new substance? If the problem isn’t addressed, they’ve simply found a new artificial “opioid.”
FR’s libertarian addicts will be sorry to learn of this.
A marine fungus will now be a controlled substance?
Stick with what God made, Opiates. They work and they work very well. There was a time in this country when Doctors were allowed to actually practice medicine, NOT Insurance companies and the opiates literally saved my life in 1979, and since Doctors were allowed to Doctor, I spent a week in a hospital bed going thru withdrawls under doctors care before I had my surgery.
I believe the Forst and Only step we need to take to alleviatye the problem is to make it a MKajor Felony for ANY person to prescribe or offer to prescribe ANY OPIATE derivitve to ANY Public Employee or Officer of the COurt. Let them live without them first.
Did I miss how this self-defeating pain problem is addressed by the new substance?
~~~
I missed it too but I skimmed and skipped when reading. I was trying to find an answer to that very question. The substance binds to opioid receptors. Cool story. How is that different than opioids and why can’t it be abused?
I think low dose naltrexone is suppose to bind and block receptors
Since when is heroin a synthetic drug.
Science writers aren't what they used to be.
Or maybe this article was written by AI.
about halfway through Lent fast everything stopped hurting.
The work around to your suggestion is they will quit, get the script, then be rehired. You might want to make it contingent on NEVER working for the government at any level.
I am good with that and until they are forced to live under their own rules, nothing will change for the better.
Worry not. People will always find a way to ruin their lives no matter what.
Here we go again.
*sigh*
People need to be DEprogrammed from believing that most pain is natural and resolved by pharmacological methods.
Most ‘pain’ - a purely personal definition in nearly every case, i.e., NOT by injury - is self-inflicted by choice, ignorant or otherwise.
Free advice: Educate yourselves.
In that case, outlaw it. Big Pharma owns the guv.
bfl
Ping!
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