Posted on 12/01/2022 5:07:44 PM PST by nickcarraway
These results are a step forward in finding a vaccine against HIV and many other pathogens.
Researchers report the positive results from a Phase 1 clinical trial focused on a vaccine against the Human Immunodeficiency Virus (HIV). The pathogen does not usually produce an immune response large enough to stop it, which has made it a dangerous and deadly virus. One of the goals in the creation of a vaccine is to find a formula that would indue the so-called broadly neutralizing antibodies (bnAb), an immune response that can step up to the challenge. And the trial shows that this vaccine can induce the bnAb precursors.
The results are fascinating. These bnAbs rarely develop during infection; in particular, bnAb-precursors B cells are uncommon in humans. But creating such an immune response would prime the body to fight infections from the globally diverse strains of HIV. And this approach could be used not just for HIV but for influenza, the hepatitis C virus, and betacoronaviruses.
In this Phase 1 trial, the participants received either two doses of placebo or two doses of the vaccine, either a low-dose version or a high-dose. These were administrated eight weeks apart. The vaccine had a favorable safety profile and it induced the right response in 35 out of the 36 recipients of the vaccine.
The approach is known as germline targeting. There are a small number of B cells in the human body in their “naïve” or "germline" state. If they encounter a pathogen, these cells will weakly bind to it, and over the course of weeks, they will produce better and better antibodies that can fully attach themselves to the virus surface and neutralize it.
The vaccine aims to stimulate these B cells to produce bnAbs. Previous attempts might have not been successful because they did not stimulate enough B cells.
While the results are very promising, it is not a straightforward step to a full vaccine against HIV. But the methods show an incredible level of control over the responses and could herald a new era of precision vaccine designs. And not just for HIV.
The development of such a vaccine, especially if distributed equitably across the world, would be revolutionary. Currently, 38.4 million people are estimated to be living with HIV, two-thirds of them in Africa. There is no cure for the infection but given the proper medication, people can live long and healthy lives. And if the viral load falls below the detection level, it is impossible for the virus to be passed on. This is defined by the slogan U=U, undetectable equals untransmittable.
And while vaccines are still a thing of the future, there is a drug called PrEP (pre-exposure prophylaxis) currently available, which effectively reduces the chance of infection by 99 percent. While great strides have been made in understanding and fighting this disease, access to life-saving drugs and to educational material about it remains incredibly unequal, with the most marginalized and at-risk communities receiving the least. Stigma, poverty, education, access to healthcare, racism, homophobia, and transphobia are the main reasons why individuals can’t get the help they need.
There has also been a distinct lack of public and government-sponsored campaigns aimed to inform and destigmatize the infection, and too often politicians and religious leaders have contributed to the spread of ignorance and misunderstanding about both HIV and AIDS.
We can’t all help find a vaccine or a cure for HIV infections, but fighting the stigma surrounding the virus and demanding our elected leaders provide equitable access to life-saving drugs is something we can all do.
The results were published in the journal Science.
Or keep your d*ck out of other people’s a**holes.
That works, too.
This will drastically reduce the yearly count of hypoxia deaths due to assfixation
Now what are we going to do with that giant AIDS quilt ?
And those who died of tainted blood transfusions like Arthur Ashe? Really cold of you.
The video is titled: “Why is HIV so hard to Cure”
maybe someone should ask the guy who might have never wanted to cure it.
And unilke Fauchi and Big Pharma's solution , your suggestion saves the taxpayers hundreds of billions of dollars.
I don’t know how widespread it was but Arthur did die if that.
Thirty years after I worked in England I still can’t give blood here because I was there during the Mad Cow Disease outbreak. Awareness on checking blood supplies soared because of Ashe’s death.
Tainted blood is screened out. That capability was developed 40 years ago.
So yes, keeping one’s d*ck out of other’s a**holes [and needle sharing with other junkies] is the best prevention for the nearly every single case.
Common, no, because of the rules for blood donation (now being changed), but it did happen - one of them killed science fiction author Isaac Asimov.
And if the viral load falls below the detection level, it is impossible for the virus to be passed on.
That is not a certainty, although it does appear to have some empirical evidence to back up the claim that it is exceedingly rare. You wouldn't want to be the one case, though. Virus titer can reach zero but it doesn't stay there when the patient departs from the medication regimen, for example. Which does happen.
“Thirty years after I worked in England I still can’t give blood here because I was there during the Mad Cow Disease outbreak”
The Red Cross actually changed the guidance on that this year, you may be able to donate.
How large an equity stake does Fauci have?
Very common in the early days….I lost a 22 year old Godson that way.
.
This is good.
However, didja notice that they're not pushing the mRNA platform here?
Today one can see TV ads for HIV medications that show two perverts pretty close to fornicating.
So far no one’s mentioned Bill Clinton’s tainted prisoner blood scandal from when he was Gov. of Arkansas on into his presidency. Some have speculated that Vince Foster was ordered to “take the fall” — that he ended up “suicided” suggests he declined.
Here’s a pretty good account from Salon
https://www.salon.com/1998/12/24/cov_23news/
Also, HIV with its multitude of symptoms was never isolated as a single cause/single source new infx to this day. This is Fauci’s Fearmongering Playbook. Read Jon Rappoport’s book AIDS, Inc.and understand it’s another Scam like SARS/COVID19. Sure, people get sick from a horrible lifestyle, lousy diet, toxic treatments and recreational drug abuse. Contaminated blood transfusions, getting sick and then treated with drugs that kill, too. All that grant money only goes to the True Believers in HIV and a vxx...
“demanding our elected leaders provide equitable access to life-saving drugs is something we can all do.”
How is it “equitable” to only give these drugs to HIV infected and not everyone else?
I remember the absolute glee from the homo lobby ghouls when Ryan White got infected.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.