Posted on 09/21/2022 8:18:56 AM PDT by ConservativeMind
New research identifies the importance of the protein adropin in preventing stiffness in the arteries of people with obesity and type 2 diabetes.
Arterial stiffness is a condition associated with aging and insulin resistance, a chronic condition associated with obesity, and is a major contributor in the development of cardiovascular disease, including heart attack and stroke.
Adropin, a protein produced by the liver and other tissues, is involved in maintaining energy balance in the body and the metabolism of fat and sugar. Previous studies have suggested that adropin also plays a role in regulating cardiovascular health. People with chronic conditions such as obesity and type 2 diabetes have been found to have lower levels of adropin in the bloodstream.
Researchers reported decreased expression of adropin in the liver was associated with both an elevated body mass index and hemoglobin A1c, a marker of glycemic control, in patients undergoing bariatric surgery. In a separate group, people with type 2 diabetes had lower adropin levels and increased arterial stiffness when compared to healthy controls.
In addition, the researchers studied arteries isolated from mice that were lacking adropin. They reported that "loss of adropin alone causes an increase in arterial stiffness, mimicking the effects of obesity and type 2 diabetes." The researchers later used adropin to treat arterial stiffening in a mouse model of obesity and type 2 diabetes and found that "adropin exposure reduces obesity and type 2 diabetes-associated arterial stiffening."
These findings suggest that people with low adropin levels are more likely to develop arterial stiffening and, therefore, greater consideration should be given to adropin as a potential therapeutic target in the prevention and treatment of cardiovascular disease in people with obesity and type 2 diabetes.
(Excerpt) Read more at medicalxpress.com ...
This should help with blood pressure, at least high systolic, from my prior readings.
Other approaches to increase artery flexibility, which instead deal with embedded soft plaques or layered hard calcium plaques include aged garlic, fucoidan, and Arterosil, among others, for soft plaques, and Vitamin K & Vitamin K2-MK4 (and maybe MK7), for the hard calcium plaques.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036858/
Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research
I thought liver was a beware of the cholesterol food...but Dr. Oz has said it's good for you.
At age 57 my blood pressure was 140/90 and was diagnozed border line diabetic. What really scared me was chest pains after eating a good restaurant meal. I quit my job and began walking on golf course gradually increasing to 5 rounds of 18 every week. That was 30 miles of walking pushing the golf cart.
In a year’s time, my blood pressure was 130/85 and my A1C was normal. I did not take any vitamins or supplements or prescription drugs. Now at age 82, I continue to exercise on treadmill & light weight lifting and have zero health issues.
In summary, regular moderate exercise and keeping weight normal beats any other method to stay healthy. I can’t even remember last time I had a colod or flu or cough. Has to be more than 15 years ago. No chest pains, no high BP, sugar levels normal.
Dietary cholesterol does not raise blood cholesterol, unless it goes over 1,000 - 1,500 mg a day.
So enjoy your cholesterol, because if we don’t eat it, we have to make it.
Your vitalness at your age continues to be an encouragement.
It’s a beautiful story with hope for all.
interesting. is liver the only source of Adropin
Correct!
Just like dietary fat does not increase body fat.
Just do some resistence work (not all cardio) like entropy12 suggested, and watch those carbs, and your body will metabolize the LDL and your liver proteins will go to work for you maybe too.
“aged garlic, fucoidan” black garlic and brown seaweed in soup, but not miso thanks!
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