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Brazilian berry recognized for effects against obesity and diabetes can also help to treat cancers (Camu-camu’s castalagin helps gut bacteria target cancer)
Medical Xpress / University of Montreal / Cancer Discovery ^ | Feb. 3, 2022 | Meriem Messaoudene et al

Posted on 02/03/2022 1:34:49 PM PST by ConservativeMind

Quebec scientists have discovered that the Brazilian camu-camu berry, already recognized for its protective effects against obesity and diabetes, can also help to treat cancers.

Bertrand Routy, an Université de Montréal's medical professor, shows one compound from the fruit can have a positive role to play in immunotherapy.

"With this research, we have proved that castalagin, a polyphenol acting as a prebiotic, modifies the gut microbiome and improves immunotherapy response, even for cancers resistant to this type of treatment," said Routy.

"Our results pave the way for clinical trials that will use castalagin as a complement to medications called immune checkpoint inhibitors in cancer patients," added Meriem Messaoudene.

In recent years, immune checkpoint inhibitors (ICI) have given patients renewed hope that their immune systems can overcome cancer resistance by revolutionizing therapies targeting melanoma and lung cancer. This type of immunotherapy activates the immune system to kill cancer cells.

A hunt for new approaches

Despite these improvements, only a minority of patients have long-lasting responses to immunotherapy akin to a cure, so researchers like Routy have been on the hunt for new therapeutic approaches. Their ultimate goal is to turn an unhealthy microbiome into a healthy one in order to strengthen the immune system.

Among the strategies Routy has come up with is one that employs prebiotics, chemical compounds that can improve the composition of the gut microbiome.

"To evaluate the beneficial effects of castalagin, we orally administered the prebiotic to mice that had received a fecal transplant from patients resistant to ICI," he said. "We found that castalagin binds to a beneficial intestinal bacteria, Ruminococcus bromii, and promotes an anti-cancer response."

The discovery will soon be tested in patients thanks to the launch of the first clinical trial combining the camu-camu berry and ICIs.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cancer; diabetes; gutmicrobiome; immunotherapy; obesity
Castalagin is also in Oak and Chestnut trees, but it does not seem available in its own extracted form.

However, it is safe to have small amount of Camu-Camu, with is a berry from South America. It is the most concentrated form of naturally-available vitamin C in the world, though, and just a teaspoon of powder provides over 1,000% of the US RDA.

If not going above a tolerable dose of that powder, you could experiment along with the study participants, at least with some castalagin.

1 posted on 02/03/2022 1:34:49 PM PST by ConservativeMind
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...
The “Take Charge Of Your Health” Ping List

This potentially high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to implement for your benefit.

Please email or private message me if you want on or off of this list.

2 posted on 02/03/2022 1:35:12 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Health issues. Everyone’s looking for that magic bullet in the form of a pill. Why can’t they stick to Viagra?


3 posted on 02/03/2022 1:39:47 PM PST by DIRTYSECRET
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To: ConservativeMind

Camu-camu

So good they named it twice.


4 posted on 02/03/2022 1:51:41 PM PST by Adder (Proud member of the FJBLGB community: /s is implied where applicable.)
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To: DIRTYSECRET
Why can’t they stick to Viagra?

Viagra is reported to have some strange side effects. For instance, Viagra combined with Rogaine will make your hair stand on end.

5 posted on 02/03/2022 1:55:55 PM PST by Jeff Chandler (THE ISSUE IS NEVER THE ISSUE. THE REVOLUTION IS THE ISSUE.)
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To: Jeff Chandler

LOL, post of the day


6 posted on 02/03/2022 2:05:32 PM PST by faucetman (Just the facts, ma'am, Just the facts )
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To: ConservativeMind

The same key ingredient, castalagin, is found in oak, chestnut, and water apple leaves. Very few of these berries and super-foods have ingredients unique only to them. It is even found in wine aged in oak barrels.


7 posted on 02/03/2022 2:09:29 PM PST by Dr. Sivana ( “to defend themselves, they are using the same weapons with which they were struck.”Pope St. Pius X)
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To: Jeff Chandler
For instance, Viagra combined with Rogaine will make your hair stand on end.

Not just your hair or so I'm told.

8 posted on 02/03/2022 2:22:30 PM PST by BipolarBob (The roar of the masses could be "Let's Go Brandon".)
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To: ConservativeMind; Caipirabob
Camu-camu’s castalagin helps gut bacteria target cancer

Cami-Cami does things to my heart rate.

9 posted on 02/03/2022 2:37:00 PM PST by martin_fierro (< |:)~)
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To: Dr. Sivana

Bkmk


10 posted on 02/03/2022 2:44:22 PM PST by ptsal (Vote R.E.D. >>>Remove Every Democrat ***)
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To: Jeff Chandler

It does, Jeff... but only for 4 hours. :)


11 posted on 02/03/2022 3:00:39 PM PST by momtothree
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To: ConservativeMind

Bookmark


12 posted on 02/03/2022 3:13:07 PM PST by Glinda Whatsit
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To: ConservativeMind

I guess they’ve milked the acai berries and Tahitian whateveryoucall it as much as they can. Time for a new miracle thingie. It’s natural!! An the lower Slobovians who eat it all live to age 130!


13 posted on 02/03/2022 3:22:56 PM PST by Seruzawa ("The Political left is the Garden of Eden of incompetence" - Marx the Smarter (Groucho))
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To: ConservativeMind

Any potential popularity will to some degree depend on how this berry tastes. Is is sweet, harsh, or flat line neutral as with Avocados? Does it need to be combined with other fruit juices to make it palatable? Does it smell like the infamous Durian of Thailand?


14 posted on 02/03/2022 3:30:52 PM PST by lee martell
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To: lee martell

It’s supposed to be bitter.


15 posted on 02/03/2022 3:44:42 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: DIRTYSECRET

Viagra was successfully used in a woman’s severe COVID-19 case


16 posted on 02/03/2022 4:05:42 PM PST by griswold3 (When chaos serves the State, the State will encourage chaos)
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To: lee martell

Durian — I’ve had fresh and frozen, and it tastes like a wonderful pudding. Its smell, unfortunately, is a combination of garlic and skunk.

The flesh is truly a wonderful thing to eat, though.


17 posted on 02/03/2022 5:44:54 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Bkmk


18 posted on 02/03/2022 8:49:34 PM PST by hope_dies_last ( )
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