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Cannabinoids From Hemp Can Block SARS-CoV-2 Infecting Cells In Vitro
https://www.iflscience.com ^ | January 12, 2022 | Tom Hale

Posted on 01/12/2022 9:59:27 AM PST by Red Badger

Certain hemp cannabinoids have the power to block SARS-CoV-2 – the virus that causes COVID-19 – from entering human cells, new research has shown.

Let’s get in here early to say that this study has only been carried out in the lab, not humans, and there’s nothing to suggest using cannabis will boost your immunity against COVID-19 – unfortunately, it’s nowhere near that simple. With that out of the way, the new research does suggest that some of these compounds could potentially pave the way towards some interesting antiviral treatments in the future.

The study was recently reported in the American Chemical Society's Journal of Natural Products.

Scientists at Oregon State University used a special chemical screening technique to sniff out certain cannabinoids found in hemp (Cannabis sativa). To their surprise, they found that a pair of cannabinoid acids – cannabigerolic acid or (CBGA) and cannabidiolic acid (CBDA) – bind to the SARS-CoV-2 spike protein in vitro.

The spike protein is a key part of coronaviruses used to hack into human cells, so binding and obstructing it could block the process the virus uses to infect people. To test out this idea, the researchers placed CBGA and CBDA in a petri dish with a bunch of human epithelial cells. When they introduced a SARS-CoV-2 spike protein into the mix, they noticed that cannabinoids prevented the entry of live SARS-CoV-2 into the human cells.

“Any part of the infection and replication cycle is a potential target for antiviral intervention, and the connection of the spike protein’s receptor binding domain to the human cell surface receptor ACE2 is a critical step in that cycle,” Richard van Breemen, lead study author and a researcher with Oregon State's Global Hemp Innovation Center, said in a statement.

“That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs," explained van Breemen.

Once again, don’t be under the illusion that smoking pot and consuming edibles will definitely have any of these effects. CBGA and CBDA will not make you feel high, as the main psychoactive effects of cannabis come from THC.

However, these two cannabinoid acids are very well tolerated by humans, meaning they have little to no negative side effects, and they’re not controlled substances. Much more research is needed – it’s also noteworthy that the research only looks at the effects of CBGA and CBDA on the alpha and beta variants, not the delta and omicron variants, which are now the most prolific strains of the virus. All caveats aside, the researchers claim these cannabinoid acids have so far shown potential as some kind of antiviral treatment for COVID-19

“These compounds can be taken orally and have a long history of safe use in humans,” van Breemen explained. “They have the potential to prevent as well as treat infection by SARS-CoV-2. CBDA and CBGA are produced by the hemp plant as precursors to CBD and CBG, which are familiar to many consumers. However, they are different from the acids and are not contained in hemp products.”


TOPICS: Agriculture; Business/Economy; Gardening; Health/Medicine
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To: Red Badger

his buddy martha steward has a line of CBD products. I buy the gummies . you can usually find a coupon code for them. no idea if they help but I take one or two a day


21 posted on 01/12/2022 10:21:53 AM PST by RummyChick
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To: pnz1

As in hash oil? Might be optimized for THC concentration. Not sure what happens to other cannabinoids.


22 posted on 01/12/2022 10:23:55 AM PST by gundog ( It was a bright cold day in April, and the clocks were striking thirteen. )
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To: Red Badger
So, the obvious inference is that head freaks don't get Covid 19.   My wife just said and if they do catch it, they don't care.
23 posted on 01/12/2022 10:24:40 AM PST by higgmeister ( In the Shadow of The Big Chicken)
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To: higgmeister

They cough so much they wouldn’t know.................


24 posted on 01/12/2022 10:35:09 AM PST by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: ManardG

It’s safe. My Norton 360 Premium and MalwareBytes Premium scanned it, and it’s clean.


25 posted on 01/12/2022 10:48:39 AM PST by Carriage Hill (A society grows great when old men plant trees, in whose shade they know they will never sit.)
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To: blueunicorn6

These dont get people high

They arent thc


26 posted on 01/12/2022 10:50:23 AM PST by Secret Agent Man (Gone Galt; not averse to Going Bronson.)
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To: Red Badger

Not all browsers have a PDF reader plug in ... especially on older Android phones. Some versions of browsers require you to download a PDF if no plug-in. Some browsers require you to choose .. if you know how.

Too many variations of browser configurations exist to make this assertion.


27 posted on 01/12/2022 10:52:08 AM PST by ManardG
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To: Secret Agent Man

“Everybody must get stoned.”


28 posted on 01/12/2022 10:55:28 AM PST by blueunicorn6 ("A crack shot and a good dancer”)
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To: ManardG

Brave, that I use, has it built in.

ALSO, you can get rid of ADOBE Acrobat pdf viewer, and use Foxit pdf viewer. It’s free........................

https://www.foxit.com/pdf-reader/


29 posted on 01/12/2022 10:57:13 AM PST by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: Red Badger

Hemp has the cbd and marajana the thc. What about a hybrid? It would have both chemicals plus the Covid blocker?? And do they have an edible version of that?


30 posted on 01/12/2022 11:10:44 AM PST by dragonblustar (2 Peter 2:14,1 Corinthians 6:18-20)
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To: EQAndyBuzz
I smoke and I haven’t gotten sick. Not going to change up now.
Ditto dude
31 posted on 01/12/2022 11:11:40 AM PST by Karma_Sherab
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To: Red Badger

My son is the only one in the extended family that hasn’t gotten the flu. He no doubt has a handle on this.


32 posted on 01/12/2022 11:14:57 AM PST by mcshot (Sucked up and spat out by the black hole of liberalism.)
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To: Red Badger

33 posted on 01/12/2022 12:02:34 PM PST by \/\/ayne (I regret that I have but one subscription cancellation notice to give to my local newspaper)
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To: Red Badger

Is there anything that pot doesn’t help? /s


34 posted on 01/12/2022 12:22:20 PM PST by A Navy Vet (USA Birth Certificate - 1787. Death Certificate - 2021. )
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To: Macoozie

Outtasight.


35 posted on 01/12/2022 12:23:29 PM PST by A Navy Vet (USA Birth Certificate - 1787. Death Certificate - 2021. )
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To: dragonblustar

There are edibles that have both the hemp and the thc. There is also a liquid lemonade that one can buy that has both in it.

Don’t take too much of that one, though, you can really get stoned.


36 posted on 01/12/2022 12:29:09 PM PST by angry elephant (Been with Trump since huge 2016 Washington state rally in May.)
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To: Red Badger

It works great no vax for me 👍🏻


37 posted on 01/12/2022 12:43:36 PM PST by NWFree (Somebody has to say it)
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To: Sparticus
"Chlorine bleach kills corona viruses in vitro, too, but I’m not ingesting that either."

So does isopropyl alcohol (rubbing alcohol) which should never be injested. Not to be confused with ethyl alcohol which is what adult beverages are made with.

We have a regiment to sanitize every item we bring in our home with either pure rubbing alcohol or Lysol or any product that has 70% isopropyl alcohol. We have yet to contract Covid.

38 posted on 01/12/2022 12:50:12 PM PST by A Navy Vet (USA Birth Certificate - 1787. Death Certificate - 2021. )
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