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Cannabinoids From Hemp Can Block SARS-CoV-2 Infecting Cells In Vitro
https://www.iflscience.com ^ | January 12, 2022 | Tom Hale

Posted on 01/12/2022 9:59:27 AM PST by Red Badger

Certain hemp cannabinoids have the power to block SARS-CoV-2 – the virus that causes COVID-19 – from entering human cells, new research has shown.

Let’s get in here early to say that this study has only been carried out in the lab, not humans, and there’s nothing to suggest using cannabis will boost your immunity against COVID-19 – unfortunately, it’s nowhere near that simple. With that out of the way, the new research does suggest that some of these compounds could potentially pave the way towards some interesting antiviral treatments in the future.

The study was recently reported in the American Chemical Society's Journal of Natural Products.

Scientists at Oregon State University used a special chemical screening technique to sniff out certain cannabinoids found in hemp (Cannabis sativa). To their surprise, they found that a pair of cannabinoid acids – cannabigerolic acid or (CBGA) and cannabidiolic acid (CBDA) – bind to the SARS-CoV-2 spike protein in vitro.

The spike protein is a key part of coronaviruses used to hack into human cells, so binding and obstructing it could block the process the virus uses to infect people. To test out this idea, the researchers placed CBGA and CBDA in a petri dish with a bunch of human epithelial cells. When they introduced a SARS-CoV-2 spike protein into the mix, they noticed that cannabinoids prevented the entry of live SARS-CoV-2 into the human cells.

“Any part of the infection and replication cycle is a potential target for antiviral intervention, and the connection of the spike protein’s receptor binding domain to the human cell surface receptor ACE2 is a critical step in that cycle,” Richard van Breemen, lead study author and a researcher with Oregon State's Global Hemp Innovation Center, said in a statement.

“That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs," explained van Breemen.

Once again, don’t be under the illusion that smoking pot and consuming edibles will definitely have any of these effects. CBGA and CBDA will not make you feel high, as the main psychoactive effects of cannabis come from THC.

However, these two cannabinoid acids are very well tolerated by humans, meaning they have little to no negative side effects, and they’re not controlled substances. Much more research is needed – it’s also noteworthy that the research only looks at the effects of CBGA and CBDA on the alpha and beta variants, not the delta and omicron variants, which are now the most prolific strains of the virus. All caveats aside, the researchers claim these cannabinoid acids have so far shown potential as some kind of antiviral treatment for COVID-19

“These compounds can be taken orally and have a long history of safe use in humans,” van Breemen explained. “They have the potential to prevent as well as treat infection by SARS-CoV-2. CBDA and CBGA are produced by the hemp plant as precursors to CBD and CBG, which are familiar to many consumers. However, they are different from the acids and are not contained in hemp products.”


TOPICS: Agriculture; Business/Economy; Gardening; Health/Medicine
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1 posted on 01/12/2022 9:59:27 AM PST by Red Badger
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To: Red Badger

In vivo, too!


2 posted on 01/12/2022 10:00:26 AM PST by ComputerGuy (Heavily-medicated for your protection)
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To: Red Badger

“Everybody must get stoned”


3 posted on 01/12/2022 10:00:48 AM PST by blueunicorn6 ("A crack shot and a good dancer”)
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To: blueunicorn6

I smoke and I haven’t gotten sick. Not going to change up now.


4 posted on 01/12/2022 10:02:44 AM PST by EQAndyBuzz (If you are vaccinated, you cannot get COVID from someone who is not vaccinated. Lighted up Karen!)
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To: Red Badger

Is there anything that cannabinoids can’t do?

Except fix Democrats?


5 posted on 01/12/2022 10:04:27 AM PST by DannyTN
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To: Red Badger

Smoking weed helps keeps the ChiComWuHu away?

Groovy

Now, if they only had weed that would keep Herpes away . . .
now THAT would be something for humanity.


6 posted on 01/12/2022 10:04:28 AM PST by Macoozie (Handcuffs and Orange Jumpsuits)
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To: Red Badger
Snoop Dawg say:


7 posted on 01/12/2022 10:04:35 AM PST by Alas Babylon! (Rush, we're missing your take on all of this!)
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To: Red Badger

The speculation in this article reminds me of Trump’s speculation about repurposing chemicals found in some household cleaners into a form suitable for human consumption. Trump was mocked for actually thinking like a scientist, whereas this article is presented as reasonable speculation (which it is).


8 posted on 01/12/2022 10:04:44 AM PST by Steve_Seattle
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To: Alas Babylon!

I bet he doesn’t get Covid....................


9 posted on 01/12/2022 10:05:08 AM PST by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: Red Badger

Seem Bynadril and pot do better than vax.

‘’We know that the two doses of the vaccine offer very limited protection, if any.’’
CEO Pfizer pharmaceuticals


10 posted on 01/12/2022 10:05:27 AM PST by ManardG
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To: Steve_Seattle

https://www.hilarispublisher.com/open-access/chlorine-dioxide-in-covid19-mechanism-of-molecular-action-in-sarscov2.pdf


11 posted on 01/12/2022 10:07:11 AM PST by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: Red Badger

12 posted on 01/12/2022 10:09:40 AM PST by Magnum44 (...against all enemies, foreign and domestic...)
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To: Red Badger

I’ve been surrounded at work over the last 2 years by people who caught it, somehow though I’ve never gotten infected with the Covid. I’ve been smoking pot for 45 years and that’s why I’ve not been infected. If big Pharma would invent a Canaris based vaccine with no mRna tech that actually prevented the spread of Covid, almost everyone would take it. Just sayin.


13 posted on 01/12/2022 10:09:52 AM PST by fatman6502002 ((The Team The Team The Team - Bo Schembechler circa 1969))
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To: Red Badger

Not opening any PDF downloads!!

Please warn people.


14 posted on 01/12/2022 10:11:52 AM PST by ManardG
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To: EQAndyBuzz

I don’t smoke and I don’t have lung cancer.


15 posted on 01/12/2022 10:12:19 AM PST by blueunicorn6 ("A crack shot and a good dancer”)
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To: Red Badger

So that’s why I haven’t gotten covid!


16 posted on 01/12/2022 10:13:13 AM PST by glorgau
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To: Red Badger

Chlorine bleach kills corona viruses in vitro, too, but I’m not ingesting that either.


17 posted on 01/12/2022 10:14:30 AM PST by Sparticus (Primary the Tuesday group!)
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To: Red Badger

Would hemp oil work the same way?


18 posted on 01/12/2022 10:14:59 AM PST by pnz1 ("These people have gone stone-cold crazy")
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To: ManardG

Your browser can open it without downloading it..........


19 posted on 01/12/2022 10:15:26 AM PST by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: Red Badger

This might explain why the homeless seem immune.


20 posted on 01/12/2022 10:21:37 AM PST by gundog ( It was a bright cold day in April, and the clocks were striking thirteen. )
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