Posted on 12/09/2021 4:04:52 PM PST by nickcarraway
Can the time of day you get your COVID-19 vaccine affect how many antibodies you'll make?
A new study suggests that it can.
Researchers found higher antibody levels in health care workers who received their vaccines in the afternoon, and they suggest that response to the vaccine may be affected by circadian rhythms.
"Our observational study provides proof of concept that time of day affects immune response to [COVID-19] vaccination, findings that may be relevant for optimizing the vaccine's efficacy," said co-senior study author Dr. Elizabeth Klerman.
Pfizer says COVID-19 vaccine booster shot ramps up protection against Omicron She's a research investigator in the Division of Neurophysiology's Unit at Massachusetts General Hospital.
Klerman emphasized that getting vaccinated, regardless of the time of day, is the most critical step in preventing COVID-19 infection.
Her team evaluated antibody levels among nearly 2,800 health care workers in Britain, whose blood samples were collected at the time of vaccination as part of the British infection prevention program.
The researchers created a model to investigate the effect on antibody levels based on time of day of vaccination, vaccine type -- Pfizer or AstraZeneca -- age, sex and the number of days post-vaccination.
They found that antibody responses were higher in general for everyone who was vaccinated later in the day. Other groups that had higher antibody responses were those who received the Pfizer vaccine, women and younger people.
While symptoms of some diseases and the effect of medications can also vary by time of day, this research contrasts with earlier studies in elderly men who had higher numbers of anti-influenza titers after getting flu shots in the morning.
"The [COVID-19] vaccine and the influenza vaccine have different mechanisms of action from each other, and antibody response may vary greatly depending on whether the immune system recognizes the pathogen from earlier infections, such as influenza, or whether it is confronted by a novel virus," Klerman said in a hospital news release.
A limitation of the study was the lack of data on participants' medical and medication history, their and shift-work patterns, which can also influence vaccine responses.
"We need to replicate our findings and develop a better understanding of the underlying physiology of [COVID-19] and the body's response to vaccination[s] before we can recommend that people who want an extra boost from the vaccine, such as older individuals or those who are immunocompromised, schedule their vaccine for the afternoon," Klerman said.
"This research is the first step in demonstrating the importance of time-of-day response to [COVID-19] vaccine," Klerman said.
Klerman and her colleagues are now analyzing data on vaccine side effects from people who got their shots at Mass General Brigham facilities.
She also hopes to have the opportunity to reanalyze data from randomized, controlled trials of the COVID-19 vaccine, to determine whether the time of day participants received the vaccine affected its efficacy.
"If antibody levels are higher when people receive the vaccine in the afternoon, we may see that side effects are also greater," Klerman suggested.
The findings were published this month in the Journal of Biological Rhythms.
The U.S. Centers for Disease Control and Prevention has more on COVID-19 vaccines.
Phase of moon also important. It’s science.
Oh give me a break.
How does the time of day affect when I refuse to get the shot?
They’re just grasping at straws now
Also depends on whether the Witch Doctor has you utter “ooo, watta goo siam”, when you receive the shot.
If you get the shot in the morning, you must be facing east toward the sun and get your shot in your RIGHT arm...VEEEEERY IMPORTANT.....
If you are facing west in the morning away from the sun, you MUST get the shot in your LEFT arm...
It’s also important if you have your eyes open or closed when get the shot...If your eyes are open, you must breathe through your nose and if your eyes are closed, you MUST breathe through your mouth...
;)
No day is complete without a new dose or 10 of pseudoscience.
If your female, and get the shot while doing a handstand, will the lipid nanoparticles stay in your shoulder and not lodge in your ovaries?
The planets need specific alignment.
Another FReeper mentioned Halley's Comet. Will need to wait for it's return.
pffft.
Now they’ll mandate what time you must be shot.
Once again proving they really don’t know anything about this vaccine, how it works on the micro level, and what impact it may have.
Just wow.
What about people that work graveyard? Their afternoon is in the middle of the night.
The girls need to instantly start doing cartwheels to get the nanoparticles to spread out...
Best time for playing Russian Roulette is never.
That needs one of those Pfizer single blind, throw out the dead participant studies.
Also color of hair, and voting history.
A new study suggests that it can.
Researchers found higher antibody levels in health care workers who received their vaccines in the afternoon, and they suggest that response to the vaccine may be affected by circadian rhythms.
Idiots! Instead of looking at circadian rhythms, how about investigating improper handling of the vaccine itself, regarding careless or inept workers using the vaccine after it had reached room temperature.
https://www.cdc.gov/vaccines/hcp/admin/storage/toolkit/storage-handling-toolkit.pdf
When the cold chain fails Ensuring vaccine quality and maintaining the cold chain are shared responsibilities among manufacturers, distributors, public health staff, and health care providers.An effective cold chain relies on three main elements:
» A well-trained staff
» Reliable storage and temperature monitoring equipment
» Accurate vaccine inventory management
Results of a cold chain failure can be costly.1,2,3 ACIP’s General Best Practice Guidelines for Immunization states, “vaccine exposed to inappropriate temperatures that is inadvertently administered should generally be repeated.”A break in the cold chain can mean extra doses for patients, increased costs for providers, and damage to public confidence in vaccines.
More importantly, patients refusing revaccination can remain unprotected from serious, vaccine-preventable diseases.
Vaccine appearance is not a reliable indicator that vaccines have been stored in appropriate conditions. For example, inactivated vaccines—even when exposed to freezing temperatures—may not appear frozen, giving no indication of reduced or lost potency.
By following a few simple steps and implementing CDC-recommended storage and handling practices, providers can ensure patients receive high-quality vaccine that has not been compromised.
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