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Moths and tree bark: How the Novavax Covid vaccine works
Nebraksa Medicine ^ | 08/11/2021

Posted on 08/11/2021 3:08:21 PM PDT by SeekAndFind

Novavax has created a fourth COVID-19 vaccine using moth cells and tree bark. Instead of an mRNA vaccine (Pfizer, Moderna) or a viral vector vaccine (Johnson & Johnson), Novavax is a subunit protein vaccine.

Infectious diseases expert Diana Florescu, MD, led the phase 3 clinical trial of the Novavax vaccine at the University of Nebraska Medical Center (UNMC). "Diversity in vaccine production helps increase the number of patients vaccinated," says Dr. Florescu. "Some might not accept mRNA vaccines, while others may be allergic to certain ingredients."

For example, some are allergic to polyethylene glycol (PEG), an ingredient in the mRNA (Pfizer and Moderna) vaccines. There's no polyethylene glycol (PEG) in Novavax.

How does the Novavax vaccine work?

The Novavax COVID-19 vaccine contains a protein (made using moth cells) plus an adjuvant (made from tree bark). An adjuvant is an ingredient added to boost a person's immune response, creating higher levels of antibodies.

The Novavax vaccine uses a telltale piece of the coronavirus: the notorious spike protein. All alone, the spike protein is harmless and can't cause COVID-19. When your immune system encounters the lonely spike protein, it produces antibodies against it. This gives you protection against future COVID-19 infection.

"Unlike mRNA vaccines, the spike protein is already premade in the Novavax vaccine. It's a shortcut," explains Dr. Florescu. "All the synthesis happens outside the body and we just give the end product: the spike protein."

Like other COVID-19 vaccines, Novavax does not cause COVID-19 infection. It can't get you sick. This vaccine doesn't contain either live or inactivated virus.

How did they get the spike protein?

The Novavax method uses moth cells to make spike proteins:

  1. Researchers select the desired genes that create certain SARS-CoV-2 antigens (spike protein).
  2. Researchers put the genes into a baculovirus, an insect virus.
  3. The baculovirus infects moth cells and replicates inside them.
  4. These moth cells create lots of spike proteins.
  5. Researchers extract and purify the spike proteins.

"The Novavax vaccine has no genetic material, only proteins," says Dr. Florescu. "The vaccine technology is more traditional, and it's very similar to a protein-based influenza vaccine."

Influenza vaccines have also used this moth cell factory method.

What does the adjuvant (soapbark tree extract) do?

Adjuvants increase the immune response to a vaccine. In this vaccine, soapbark tree extract adjuvant makes achieving immunity possible with a smaller dose of the spike protein.

Matrix-M is the adjuvant used by Novavax. It is based on a saponin extracted from the soapbark tree (Quillaja saponaria). The soapbark extract encourages immune cells to activate, generating a more potent immune response.

Saponins are found naturally in various plant species like beans and green peas. They're used in agriculture, animal feeds, veterinary vaccines and human food. Saponins can boost immune responses to proteins. Using the Matrix-M adjuvant, a smaller dose of spike protein achieves the desired immune response.

See how well the Novavax vaccine performed in phase 3 clinical trials here.


TOPICS: Health/Medicine; Science; Society
KEYWORDS: covid19; novavax; vaccine
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1 posted on 08/11/2021 3:08:21 PM PDT by SeekAndFind
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To: SeekAndFind

So the big question is... Safer than the other offerings of Big Pharma, or just a different public relations department?


2 posted on 08/11/2021 3:12:54 PM PDT by Retrofitted
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To: SeekAndFind

Tree bark.

By no means a novel concept.

Known to none other than the Father of our Country, George Washington.

HCQ, Quercetin trace back to a similar source.

These people have a lot of nerve.


3 posted on 08/11/2021 3:15:33 PM PDT by one guy in new jersey
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To: SeekAndFind

How about we replace the entire mRNA component with a new HCQ or Ivermectin compon entertainment (i.e., known effective therapeutics), call it an oral form of the same vaccone (even though that’s not true), swear up and down that this does not mean that the Bad Orange Man said a single thing that was true in his entire life, and call it a day.


4 posted on 08/11/2021 3:20:12 PM PDT by one guy in new jersey
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To: one guy in new jersey

Autocorrect edit:

compon entertainment = component
vaccone = vaccine


5 posted on 08/11/2021 3:22:14 PM PDT by one guy in new jersey
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To: Retrofitted

Novavax’s Adjuvanted COVID-19 Vaccine Caused Severe Adverse Reactions in Clinical Trials:

https://thevaccinereaction.org/2020/09/novavaxs-adjuvanted-covid-19-vaccine-caused-severe-adverse-reactions-in-clinical-trials/

Toxicology. Quillaja saponin (sapotoxin) is reported to be highly toxic. 3 Severe toxic effects following the ingestion of large doses of the bark include liver damage, gastric pain, diarrhea, hemolysis, respiratory failure, convulsions and coma.

https://www.drugs.com/npp/quillaja.html#:~:text=Toxicology.%20Quillaja%20saponin%20%28sapotoxin%29%20is%20reported%20to%20be,and%20coma.%201%20Digitalis%20may%20stabilize%20cardiac%20involvement.

This is their adjuvant: MATRIX-M1 ADJUVANT (UNII: YZ7P8Y8ECX)—quillaja saponin???

Someone tell me I am getting this incorrect. Please?


6 posted on 08/11/2021 3:28:04 PM PDT by packagingguy (Kit)
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To: SeekAndFind
This should have lots of appeal to the Earthy Crunchies.

7 posted on 08/11/2021 3:28:18 PM PDT by Governor Dinwiddie ("Success is 10 percent inspiration and 90 percent perspiration." — Thomas Edison)
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To: one guy in new jersey

“ Autocorrect edit:

compon entertainment = component…”
***************************************
LOL - It’s amazing the “corrections” that autocorrect can come up with.


8 posted on 08/11/2021 3:28:32 PM PDT by House Atreides
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To: SeekAndFind

The spike protein IS THE TOXIN!!!

Even without the body of the virus, our body (and those of test animals) show the same inflammation response to just the spike protein.

https://rumble.com/vkopys-a-pathologist-summary-of-what-these-jabs-do-to-the-brain-and-other-organs.html


9 posted on 08/11/2021 3:30:21 PM PDT by datura (The voice that brought you peace has nothing left to say.)
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To: House Atreides

Not sure, but my smart phone may be in the thrall of Lucifer’s lexicographer.


10 posted on 08/11/2021 3:31:35 PM PDT by one guy in new jersey
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To: SeekAndFind

Sounds like an herbal remedy. :)


11 posted on 08/11/2021 3:34:02 PM PDT by TigersEye (Who shot Ashli Babbitt?)
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To: SeekAndFind

CRISPR

Genesis 6
Leviticus 19
Matt 24:37

Hybridization Initiation.


12 posted on 08/11/2021 3:35:39 PM PDT by Varsity Flight ( "War by the prophesies set before you." I Timothy 1:18)
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To: SeekAndFind

So, the tree bark makes it cost effective.

Spikes collected from “moth cells” sounds safer than grown in my heart cells, but more expensive, so I suppose they want to use less.


13 posted on 08/11/2021 3:38:01 PM PDT by Empire_of_Liberty
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To: SeekAndFind

Does anyone know if it was developed or tested using cell lines from aborted human fetuses or embryos?


14 posted on 08/11/2021 3:38:46 PM PDT by scouter (As for me and my household... We will serve the LORD.)
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To: SeekAndFind

Bttt.

5.56mm


15 posted on 08/11/2021 3:40:28 PM PDT by M Kehoe (Quid Pro Joe and the Ho need to go.)
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To: packagingguy

Dosage makes the poison.

For example, a number of blood pressure medicines are not much more than small amounts of snake venom (anything ending in -pril).

Captopril, in particular, is pretty much just pit viper venom.

Mind you THIS IS NOT an endorsement of this vaccine. But the fact that a little bit of poison is in it is pretty common with all medicines.


16 posted on 08/11/2021 3:47:31 PM PDT by Jewbacca (The residents of Iroquois territory may not determine whether Jews may live in Jerusalem)
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To: SeekAndFind

This would be a more acceptable vaccine to me. If I needed a vaccine.


17 posted on 08/11/2021 3:54:56 PM PDT by wgmalabama (We will find out if the Vac or virus risk was the correct choice - can we put truth above narrative)
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To: packagingguy
RE: Severe toxic effects following the ingestion of large doses of the bark include liver damage, gastric pain, diarrhea, hemolysis, respiratory failure, convulsions and coma.

Almost anything, any substance, taken in large doses will produce severe reactions, even Tylenol.
18 posted on 08/11/2021 3:56:56 PM PDT by SeekAndFind
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To: packagingguy

The “severe Adverse Reactions” cited in the first link are such things as “fatigue”, “malaise”, temp of 101.5. The article also says that these reactions were limited to 2 days on average. It does not list any long term negative effects.

The toxicology link you gave pointed out that there are safe amounts of the saponin compound in foods. The first link, in the comments, points out that saponin occurs in root beer. Of course, ingesting a compound is different than injecting a compound. But, at any rate, it’s toxicity is not quite as bad as it sounds. The purpose of an adjuvant is to increase the immune response of the body. So it wouldn’t do to use salt water.


19 posted on 08/11/2021 3:57:51 PM PDT by the_Watchman
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To: SeekAndFind

CAUTIONARY NOTICE: Recipients strangely develop an uncanny attraction to open flames and a strong desire to climb trees.


20 posted on 08/11/2021 3:58:17 PM PDT by TomGuy
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