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Diabetes drug found to slow, or in some cases prevent, Parkinson’s
newatlas.com ^ | October 27, 2020 | By Rich Haridy

Posted on 10/28/2020 9:37:45 AM PDT by Red Badger

The diabetes drug exenatide is currently being investigated as a Parkinson's treatment in Phase 3 human trials Esbenklinker/Depositphotos

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A large population-based cohort study, led by researchers from University College London, is suggesting some drugs used to treat diabetes may also prevent the onset of Parkinson’s disease. Along with prior research, these new findings help validate an upcoming Phase 3 human clinical trial set to test one particular diabetes drug in Parkinson’s patients.

Following several years of conflicting studies, a large and somewhat definitive 2018 study confirmed a link between type 2 diabetes and Parkinson’s disease. Following several million subjects, the study found type 2 diabetics were 32 percent more likely to develop Parkinson’s disease.

Alongside these findings, substantial preclinical and preliminary human research has been chronicling the effect of a drug called exenatide on Parkinson’s disease symptoms. Most recently, a placebo-controlled study with a cohort of 60 Parkinson’s patients suggested exenatide may slow the progression of degenerative motor symptoms.

This new study, published in the journal Brain, investigated medical records from over 100,000 people diagnosed with type 2 diabetes. The cohort was broken down into different groups depending on what particular diabetes drug treatment they were administered.

The findings revealed notably lower rates of Parkinson’s disease diagnoses in those diabetic subjects taking one of two classes of diabetes drug: GLP-1 agonists and DPP4 inhibitors. Exenatide is a GLP-1 agonist.

Co-lead author on the new study, Tom Foltynie, says these findings certainly help add weight to the link between type 2 diabetes and Parkinson’s disease. He also points out the research offers clear signals a drug such as exenatide may actually alter the course of the disease, and not merely improve symptoms.

“We have added to evidence that exenatide may help to prevent or treat Parkinson’s disease, hopefully by affecting the course of the disease and not merely reducing symptoms, but we need to progress with our clinical trial before making any recommendations,” says Foltynie.

Foltynie is leading the Phase 3 clinical trial set to explore the disease-modifying effect of exenatide on Parkinson’s patients. The trial is currently recruiting 200 subjects who will either take exenatide or a placebo once weekly for two years.

Li Wei, co-lead author on the new study, suggests it is certainly too early for doctors to offer exenatide to Parkinson’s patients. However, Wei does point out doctors should consider Parkinson’s risk factors when determining diabetic treatments.

“It may be helpful for doctors to consider other risk factors for Parkinson’s disease when prescribing medications for type 2 diabetes, but further research will be needed to confirm clinical implications,” says Wei.

The new study was published in the journal Brain.

Source: University College London


TOPICS: Health/Medicine; History; Science; Society
KEYWORDS: diabetes; diabetesdrug; exenatide; parkinsons

1 posted on 10/28/2020 9:37:45 AM PDT by Red Badger
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To: Red Badger

and the drugs cost will skyrocket


2 posted on 10/28/2020 9:39:28 AM PDT by Secret Agent Man (Gone Galt; Not Averse to Going Bronson.)
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To: kalee

For later.


3 posted on 10/28/2020 9:46:49 AM PDT by kalee
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To: Red Badger

Yada, yada, yada.
Here’s hoping...but lots of mileage to go.


4 posted on 10/28/2020 9:52:43 AM PDT by Getready (Wisdom is more valuable than gold and diamonds, and harder to find.)
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To: Red Badger

The method which lowered my H1C from pre-diabetic range down to normal range was free of additional costs. I began using the treadmill every day at the community gym where I already was paying HOA dues. Not only my H1C improved, my blood pressure also improved. And my energy level is off the charts for a 80 year old man.

Conclusion: Exercise is the best option to maintain good health. Now looking forward to reaching 100 without pain and without needing a wheel chair.


5 posted on 10/28/2020 9:57:34 AM PDT by entropy12
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To: entropy12

Awesome! Great to hear. :D


6 posted on 10/28/2020 10:01:47 AM PDT by GOP Poet
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To: entropy12

Congratulations on taking charge and renewing your health. Our bodies were created to work and move every day.

Peach


7 posted on 10/28/2020 10:19:43 AM PDT by CarolinaPeach
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To: Red Badger

A true diabetes preventative would be truly a Godsent for millions of people. Diabetes is the source of many other deseases.


8 posted on 10/28/2020 11:09:24 AM PDT by 353FMG
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To: entropy12

Using a treadmill is about the most boring thing a human can do as far as I am concerned. What techniques do you use to avoid the boredom?


9 posted on 12/16/2020 5:14:27 AM PST by mad_as_he$$ ("I don't know why they still make bolts." David Freiburger)
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To: mad_as_he$$

You are exactly 100% right... treadmill is as boring as it gets. I have 200 of my most favorite songs & music stored on my smart phone as MP3 files and I play it using a free app called Musicolet and I can listen to it during treadmill via Bluetooth so it is wireless. The phone is parked on a window nearby. I can choose via Musioclet which playlist I want to listen, such as Mozart or Pop or select a certain group such as Beetles or Abba, or a combination of any MP3 files.

The benefits of keeping this discipline of doing one mile in 23 minutes at 2 deg up-slope are so huge for my 80 year old body, I will be stupid to quit. I have no balance issues, no leg joint pains or cramps, the heart is working flawless, and I swear I could join a ballet class if I wanted to. Never ever expected to feel this athletic at 80 when I retired at age 57 with hip joint pain, racing heart, fainting spells at work, panic attacks in closed malls. All those issues are gone!


10 posted on 12/16/2020 12:00:12 PM PST by entropy12 (Those who vote decide nothing, those who count votes decide everything--Joseph Stalin)
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To: 353FMG

Diabetes preventive is already available to everyone at no cost. Limit all calorie intake during ANY 9 hours in a 24 hour period. And walk 1 mile daily at brisk pace. I was diagnosed prediabetic in mid-50’s. Began walking on golf course gradually increasing to 5 rounds of 18/week. All health issues disappeared. At age 75 I quit the private golf course (unlimited rounds for fixed monthly fee) and now doing boring treadmill 6-7 times every week. Still feeling great at age 80.


11 posted on 12/16/2020 12:23:00 PM PST by entropy12 (Those who vote decide nothing, those who count votes decide everything--Joseph Stalin)
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To: entropy12

Thanks for the reply! I will try music. I have been watching the TV.


12 posted on 12/16/2020 2:07:13 PM PST by mad_as_he$$ ("I don't know why they still make bolts." David Freiburger)
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