Posted on 09/18/2019 12:59:13 PM PDT by Red Badger
Prescribing metformin and vildagliptin to people newly diagnosed with type 2 diabetes reduced their long-term blood sugar levels more than single-drug therapy in a recent study.
Sept. 18 (UPI) -- When it comes to controlling early symptoms of type 2 diabetes, two drugs are better than one, a new study says.
Prescribing metformin and vildagliptin to people newly diagnosed with type 2 diabetes reduced their long-term blood sugar levels more than single-drug therapy, according to findings published Wednesday in The Lancet. The patients also had lower rates of treatment failure than those who only used Metformin, the current first-line drug used by new type 2 diabetics.
"The findings of VERIFY support and emphasize the importance of achieving and maintaining early glycaemic control," the authors wrote.
The VERIFY study was also presented at the Annual Meeting of the European Association for the Study of Diabetes in Barcelona.
Researchers recruited 2,001 patients in 254 medical centers in 34 countries, randomizing 998 to receive the early combination therapy and 1,003 who only received metformin.
Some patients took a combination therapy of one daily dose of between 1,000 and 2,000 milligrams of metformin and a twice-daily dose of 50 milligrams of vildagliptin. The monotherapy group took the same daily dosage of metformin and placebo twice a day.
The patients had their HbA1c blood sugar levels monitored every 13 weeks.
Anyone in the monotherapy group whose HbA1c levels rose above 53 mmol/mol during two consecutive monitoring sessions had a treatment failure. They were then prescribed the combination therapy.
Those in the early combination therapy group whose levels went above 53 mmol/mol just continued the regime.
Nearly 44 percent of patients in the early combination group had treatment failure versus more than 62 percent of patients in the monotherapy group.
If either group had another failure after two more monitoring sessions, they were placed on insulin treatment.
The early combination group had half the likelihood of losing blood sugar control than the monotherapy group. They also had a 26 percent lower risk of having HbA1c levels above 53 mmol/mol than the group moved from monotherapy to combination therapy after first treatment failure.
"Early intervention with a combination therapy strategy provides greater and durable long-term benefits compared with the current standard-of-care monotherapy with metformin for patients with newly diagnosed type 2 diabetes," the authors wrote.
In Agriculture class we were taught that the government created the food pyramid as a marketing idea for dairy farmers. This was way back in the early 20th century. They wanted people to think they needed to drink milk and eat cheese.
The food pyramid was built by lobbyists.
The average people of this country are lemmings going over a cliff.
Conservative are generally above average on independent thought.
What ever happened to the question authority bumper stickers?
IF you are NOT terribly overweight and have type-2; you may have been misdiagnosed...check into type 1.5 (LADA).
Thank for the compliment. My goal is to be about 195-considered the weight for a normal BMI.
Link doesn’t work
PS I know that a couple of Ultralights won’t mess me over
Absolutely. It’s really scary to not only see the level of ignorance, but the level of arrogance too. Makes it a little easier to understand the NeverTrumpters. It’s a mindset.
https://www.delish.com/food/g26987069/low-carb-beer/
sorry about that, I’ve tried some and they’re OK but I still pine for my Belgian ales.
/jk
It's not about "fault". Type II is a dietary disease. That's a fact. You can control it by controlling your diet. It's not your fault that this hasn't been what you've been told, but it is up to you to act on it.
I was diagnosed in July. Already down from 280 to 260, maybe a little lower (last weighed 10 days ago).
A1C down from 8.7 to 7.8. Definitely watching my carbs.
Veterans Administration assigned me a very nice nurse practitioner, who, unlike most MDs I’ve encountered, is actually willing to listen to me.
She just halved my glypizide and said that if I get down to about 240 I should be off meds entirely. Hope she’s right.
Great link that led me to even more lo-carb sweet pepper recipes...my bumper crop of bells demands it!
“Type II is a dietary disease. That’s a fact.”
No , that’s bullcrap.
Yes, you can CONTROL it to a point with diet. Depending on the severity, you be able to bring A1C levels down to normal by diet alone. But guess what? Even then you STILL are diabetic. You haven’t cured anything. You still are not converting sugar to energy properly, your cells are still starving for energy. A1C is not the whole story.
Type 2 is hereditary. If you are going to get it you are going to get it. It doesn’t matter what you do or do not do. THAT is a fact.
“Type 1 or Type 2?”
It doesn’t matter. The answer is the same.
“AND you live in New York on top of that.”
Yeah, well, somebody has to stay and fight the liberal dirt bags who have ruined this once great State. My family has been here for well over 200 years. I am not letting a bunch of relative newcomers chase me out. Not yet, and not without a fight. This is MY home, not theirs.
That might not have been all bad-cheese is good-milk is for babies and very small kids-not adults-but somewhere after the original, all those starches from processed grain products got added to the pyramid-white rice and flour from bleached and hulled grains that are just starch and carbs with almost no nutrients-and then instead of healthy, natural butter they pushed that veggie oil-based abomination called margarine-I saw sticks of that stuff at a couple of friends’ houses-my mom never had a stick or a tub of margarine on our table-and there is none on mine, either...
You’re welcome-I’d like to see a few young people who were advised to use that food pyramid as a dietary guide and did so to sue for morbid obesity, diabetes type II, etc, etc-I’ll bet some grandstanding attorney would take the case and file that suit...
I take 1000mg of metformin twice a day. I also take glipizide and Victoza. My fasting sugars usually stay around 125 to 130 unless I am battling an infection like I am now.
Type II is a dietary disease. Thats a fact.No , thats bullcrap.
Yes, you can CONTROL it to a point with diet. Depending on the severity, you be able to bring A1C levels down to normal by diet alone. But guess what? Even then you STILL are diabetic. You havent cured anything. You still are not converting sugar to energy properly, your cells are still starving for energy. A1C is not the whole story.
Type 2 is hereditary. If you are going to get it you are going to get it. It doesnt matter what you do or do not do. THAT is a fact.
It isn't bullcrap. You've been misinformed.
Type II is when your body becomes unresponsive enough to insulin that it can't control glucose. You still produce insulin, it just doesn't work as well. This desensitization is called Insulin Resistance and it part of the Metabolic Syndrome complex.
This happens gradually and is a consequence of prolonged exposure to high levels of insulin, triggered by persistent high levels of glucose. Over time, the more insulin your body secretes the less effective it becomes. The glucose, and the insulin response it generates, are a consequence of diets high in foods that create glucose.
It is not a heriditary disease and the idea that if you're going to get it, you're going to get it, no matter what, is complete nonsense.
Also, it is not true that if you control it with diet you are still starving your cells. Completely false. With the proper diet you not only bring down A1C, but over time you reverse the insensitivity, potentially to the point where insulin response becomes normal.
Type II Diabetes is a dietary disease. That is a fact. I don't blame anyone for not knowing this, as it's been obscured by a lot of very bad nutrition science. But it's still true, whether you know it or not.
Thanks Red Badger. Maybe Bill Maher will want to weigh in on diabetes prevention?
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