Skip to comments.Two-drug combo more effective at lowering blood sugar in diabetes patients
Posted on 09/18/2019 12:59:13 PM PDT by Red Badger
Prescribing metformin and vildagliptin to people newly diagnosed with type 2 diabetes reduced their long-term blood sugar levels more than single-drug therapy in a recent study.
Sept. 18 (UPI) -- When it comes to controlling early symptoms of type 2 diabetes, two drugs are better than one, a new study says.
Prescribing metformin and vildagliptin to people newly diagnosed with type 2 diabetes reduced their long-term blood sugar levels more than single-drug therapy, according to findings published Wednesday in The Lancet. The patients also had lower rates of treatment failure than those who only used Metformin, the current first-line drug used by new type 2 diabetics.
"The findings of VERIFY support and emphasize the importance of achieving and maintaining early glycaemic control," the authors wrote.
The VERIFY study was also presented at the Annual Meeting of the European Association for the Study of Diabetes in Barcelona.
Researchers recruited 2,001 patients in 254 medical centers in 34 countries, randomizing 998 to receive the early combination therapy and 1,003 who only received metformin.
Some patients took a combination therapy of one daily dose of between 1,000 and 2,000 milligrams of metformin and a twice-daily dose of 50 milligrams of vildagliptin. The monotherapy group took the same daily dosage of metformin and placebo twice a day.
The patients had their HbA1c blood sugar levels monitored every 13 weeks.
Anyone in the monotherapy group whose HbA1c levels rose above 53 mmol/mol during two consecutive monitoring sessions had a treatment failure. They were then prescribed the combination therapy.
Those in the early combination therapy group whose levels went above 53 mmol/mol just continued the regime.
Nearly 44 percent of patients in the early combination group had treatment failure versus more than 62 percent of patients in the monotherapy group.
If either group had another failure after two more monitoring sessions, they were placed on insulin treatment.
The early combination group had half the likelihood of losing blood sugar control than the monotherapy group. They also had a 26 percent lower risk of having HbA1c levels above 53 mmol/mol than the group moved from monotherapy to combination therapy after first treatment failure.
"Early intervention with a combination therapy strategy provides greater and durable long-term benefits compared with the current standard-of-care monotherapy with metformin for patients with newly diagnosed type 2 diabetes," the authors wrote.
From $4 a month to $400 per month.
No mention of diet and exercise. Just make the drug companies richer.
When I was first diagnosed (with an A1C of 13.7) the ‘nutritionist’ (i use that term loosely, because she was an idiot) told me a diet of no more than 10% fat (not even 20%) and at least 100g of carbs with EACH MEAL was the recommended plan to ‘control’ my diabetes...
I shudder to think how many meds I’d be on and how many limbs I would have lost by now had I not found Atkins and then Keto/fasting.
Last A1C (with no meds at all) 4.9.
“one daily dose of between 1,000 and 2,000 milligrams of metformin”
Medical Underwriter here. That’s a big dosage. A typical Type II dosage for Metformin is 500mg and with diet and exercise not cutting it, then 1000mg. But 2000mg? Wow. and $$$.
Quit eating Sugar and get OFF Meds 100% for 0$
Congrats to you and well done. A1C of 4.9 is awesome.
The Magic Pill
*** “Last A1C (with no meds at all) 4.9” ***
You are Rocking it! I have had different but similar results
<45lbs in 8 months and off ALL Meds, I feel great and the gals say I look great too!
Type 2 Diabetes is a self induced illness, quit doing what you are doing to create it and it will clear up all on it’s own with NO PILLS or SHOTS!!!
In other words CHANGE YOUR EATING HABITS to High Fat, Moderate Protein and Low Carb
I can live with that!...................
With Intermittent Fasting.
Since January I have lost 80 pounds. From 300 to 220.
My morning fasting blood sugar has been between 85 and 95.
Tomorrow I have lab work done. I am hoping I can get off metformin. I had been taking 4 pills (2 metformin and 2 glipizide) a day for type II but now I am down to one metformin. Hopefully tomorrow, the one metformin goes away too!
I am waiting for the new Light Beer treatment. It may work when Coors Light is combined with Miller Light but not to exceed one case and not less than two six packs in a 24 hour period.
I have done that and have gotten off 3/4 of my Type II meds.
I try to keep down the sugar, but it is very difficult.....................
How many of the “new” diabetes drugs have been recalled in recent years? I’m more inclined to stay with well known meds for diabetes.
Vildagliptin apparently is not in widespread use, at least in the US.
My husband’s type 2 has been brought under control with the Atkins diet. It’s amazing.
Excellent & well done. Is 220 your desired weight? Hopefully, your blood results will allow you to kick metformin to the curb.
A friend and neighbor of mine had a dietician/nutritionist recommend that low fat/carb-fest diet to her last year-her kitchen was stocked with enough pasta, potatoes and rice to see her through 6 months of a famine, and she was gaining even more weight till another neighbor and I turned her on to the Paleo and Keto way of eating-once she got with the program, she started losing weight, was not tired at work and now she is not on any meds any more-and her numbers are low and normal. I guess some nutritionists and dieticians have been living off-grid in the Alaskan bush totally isolated from the internet and other humans for the last 4-5 years...
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