Posted on 02/27/2018 9:53:11 AM PST by nickcarraway
Destiny Pharma’s antibiotic for post-surgical infections will begin its clinical development after the FDA accepted its Investigational New Drug application.
Destiny Pharma wants to combat the growing antibiotic resistance crisis by targeting post-surgical Staphylococcus aureus infections like methicillin-resistant Staphylococcus aureus (MRSA). The FDA has accepted an investigational new drug application (IND) for Destiny’s MRSA candidate, XF-73, which will allow the company to complete Phase I and finalize the design of a Phase II trial.
XF-73 is a dicationic porphyrin molecule, which is a member of a new class of antibiotics called XF drugs. Interestingly, XF-73 is a nasal gel, which is administered to reduce the entry of S.aureus through the nose, which represents the source of around a third of all post-surgical infections. The candidate has demonstrated a number of major advantages over current drugs, including their capacity to kill bacteria even when they’re not actively growing, to attack bacteria in biofilms, a structure that normally protects them from antibiotics.
Destiny launched a £15.3M (€16.7M) IPO on the London Stock Exchange’s AIM market in September and the company’s stock price is up by over 3% this morning. Another company working on new antibiotics is Motif Bio, which is hoping to bring its candidate, Iclaprim, to market after it achieved positive Phase III results.
This will be a VERY expensive drug. $500? $1000?
This news, plus the news that the japanese have a new flu vaccine that wipes out the flu, with one pill, in 24 hours, and makes it non contagious while it is kicking the flu for that 24 hours- There’s also going to be a one time a year vaccine that covers more flu strains- lots of new things coming around it seems
Is it in the air or are they not sterilizing air tubes and anesthesia equipment properly.
Damned thing nearly killed me in 2011..2 weeks in Hospital...105 temp...doctors didn’t know if I was gonna live. Glad to hear this...
“This will be a VERY expensive drug. $500? $1000?”
When it comes to inflated medication cost for those of us who can pay $1000.00 is nothing. My wife is on two medications that cost more than a grand each every month. Thanks to Obama my co-payment for them have doubled. Also, I had MRSA a few years ago and would have gladly paid whatever they asked for a cure.
My mother wasn’t as fortunate. She fought post-surgical MRSA for a little over a week before it killed her. This medicine might have saved her
Pathway is mostly from our hands to our face - the nose is the most susceptible for transporting microbes from our fingers to a nice warm growth medium.
If they are just now obtaining an IDE approval it will be several years until a commercial introduction.
“Damned thing nearly killed me in 2011..2 weeks in Hospital...105 temp...doctors didn’t know if I was gonna live. Glad to hear this...”
By the time the wretched government gets around to approving any of these maybe our grand kids can benefit.
“
This news, plus the news that the japanese have a new flu vaccine that wipes out the flu, with one pill, in 24 hours, and makes it non contagious while it is kicking the flu for that 24 hours- There’s also going to be a one time a year vaccine that covers more flu strains- lots of new things coming around it seems”
It sucks that we’d have to go to Japan to get cured.
Moisture may be far more important than temperature.
it;s going to come here too0- just needs approval- they say it ‘should be’ here around the fall or early next year- We’ll see though- they are fast tracking it overseas- but here i think it’s harder to fast track
An expensive new drug . Say your prayers and hope that Staph won’t adapt to it as well.
I had it in 2009. I was in a hospital for less than a week but they listed me in Serious condition for two days.
My infection occurred in my armpit. Started out looking like a tiny pimple on a Friday, went to marble size on Monday, and golf ball size on Monday and into a hospital on Tuesday when it spread to my chest.
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