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Posted on 08/09/2025 9:57:34 PM PDT by SeekAndFind
Hiroshima University researchers have found that fermented stevia extract may fight pancreatic cancer without harming healthy cells—potentially making it more than just a zero-calorie sugar substitute.
art samuel/Shutterstock
Pancreatic cancer shows significant resistance to existing treatments like surgery, chemotherapy, and radiation.
“Globally, the incidence and mortality rates of pancreatic cancer continue to rise, with a five-year survival rate of less than 10 percent,” study coauthor Narandalai Danshiitsoodol, associate professor at Hiroshima University, said in a press statement.
There’s a growing need to find new, effective cancer-fighting compounds—especially those that come from medicinal plants, said Danshiitsoodol.
The study, recently published in the International Journal of Molecular Sciences, found that when stevia is fermented with a probiotic, the resulting extract kills pancreatic cancer cells while sparing healthy kidney cells. The fermented extract inhibited cancer growth but did not harm normal cells.
The research team fermented stevia leaf extract using the probiotic Lactobacillus plantarum SN13T, a beneficial bacterium commonly found in fermented foods like sauerkraut, pickles, and kimchi. The researchers noted that fermenting the extract with bacteria can change its structure and produce beneficial compounds called bioactive metabolites.
“To enhance the pharmacological efficacy of natural plant extracts, microbial biotransformation has emerged as an effective strategy,” Masanori Sugiyama, a professor of microbiology and biotechnology and coauthor of the study, said in a press statement.
Sugiyama’s lab has studied more than 1,200 strains of bacteria from fruits, vegetables, flowers, and medicinal plants, evaluating their health benefits.
The results showed that the fermented stevia leaf extract (FSLE) was more effective at killing cancer cells than the nonfermented version.
Sugiyama said that FSLE was also less harmful to the HEK-293 cells, which are human kidney cells used in the study. Even at the highest dose tested, FSLE caused minimal damage to these cells.
This is important because conventional chemotherapy, such as cisplatin, can damage the kidneys—especially the left one, which is adjacent to the pancreas.
Further analysis identified a compound called chlorogenic acid methyl ester (CAME) as the key anticancer agent. Fermentation reduced the amount of chlorogenic acid—a precursor to CAME—in the extract by sixfold, a change caused by bacterial enzymes, according to Danshiitsoodol.
“This microbial transformation was likely due to specific enzymes in the bacteria strain used,” she said.
CAME was found to stop cancer cells from multiplying, trigger them to self-destruct, and change the expression of key genes so that cells are more likely to die.
The experiments were conducted on cancer cells grown in laboratory dishes—not in living organisms. The researchers plan to conduct tests in mice to better understand how different doses of the fermented extract affect the entire body.
They emphasized that their results help explain how probiotic bacteria can boost the anticancer effects of herbal medicines. Danshiitsoodol noted that the study significantly advances understanding of how the Lactobacillus plantarum SN13T strain works in fermenting herbal extracts, and it also offers insight into using probiotics as natural antitumor agents.
Dr. Joseph Mercola, a board-certified family medicine physician not involved in the study, called the research “a powerful reminder” that plants like stevia offer more than just sweetness—they may deliver compounds that support long-term health.
Mercola noted that stevia extract is a “far healthier” alternative to artificial sweeteners like aspartame, sucralose, or saccharin. “Unlike synthetic options that can disrupt gut bacteria or trigger metabolic changes, pure stevia extract—which has a glycemic index close to zero—has minimal to no impact on your blood sugar or insulin,” he added.
However, he cautioned that sweeteners blended with stevia—such as those containing dextrose or maltodextrin—can raise blood sugar if taken in large amounts.
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Danshiitsoodol
Hope it works, because as a sweetener its taste is vile
If you or someone you know is fighting cancer ..I wish you or them the very best.
When they start testing this in living humans with pancreatic cancer then it might be something...in the meantime, I hope they are really are on to something...
She had two risk factors: smoking and drinking. Luckily I don't have either vice.
My best friend died of pancreatic cancer....way back in 2010.
Or we will never hear about it again. Israel had a significant breakthrough against cancer and never heard another word about it.
How in the world do they come up with this stuff? Who says “Let’s ferment stevia and see what happens?”
Don’t get me wrong,,,I think its great. But it just amazes me when they announce findings like this. Some weird concoction that kills cancer...
I think there are a lot of benefits to Stevia.
HOwever, the crap that is in our foods, is not pure Stevia. It’s cut with erythritol which causes cancer in mice.
Allulose is a great natural sugar, zero cals, that helps you sleep better, but even the crap at the store has that erythritol in it.
I tried growing Stevia this year, and drying in, but that takes time. There are reputalvbe suppliers out there.
Stevia is a good one.
Lots of things kill cancer cells... in petri dishes. (Or in animals). The trick is finding some that work in humans without being so toxic it does more harm than good.
Where can I get some FAST? You don’t want to see my latest MRI reports.
Bkmk
One of my wife’s cousins found out he had pancreatic cancer about three weeks ago. His funeral was this past Friday. He hadn’t been feeling good for “awhile”, but by the time they caught it, it was too late.
“Danshiitsoodol”
No kidding.. what a name!
You sound like you have some familiarity with pancreatic cancer
My mother died of pancreatic cancer and I have battled chronic pancreatitis for decades. It’s an ugly way to go.
“Let’s ferment stevia and see what happens?”
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
https://scitechdaily.com/scientists-supercharge-sugar-substitute-and-it-starts-killing-cancer/
Right... and not only that, ferment it with a ‘specific bacteria from banana leaves’....
“Researchers at Hiroshima University have found that stevia, when fermented with specific bacteria from banana leaves, gains a remarkable ability to kill pancreatic cancer cells while leaving healthy kidney cells unharmed.”
Nature is an amazing thing.
The chemo for PC is devastating. It can cause subsequent problems that are almost as life threatening as the cancer itself. It includes kidney and gastric issues that can cause lifelong damage.
The PC community cheered when the 5 year SEER went over 10%. Anything to push it higher—even just a bit—would be a huge win.
6,000 Patents Hidden By The Government | U.S. Invention Secrecy Act
Be sure to read thru the comments below the video:
“Apparently they had no problem with the Jab virus patents.”
https://www.youtube.com/watch?v=sNR_6aBQyDk
https://www.youtube.com/@FORGOTTENHISTORYCHANNEL
In 1998, Stanley Meyer claimed to invent a car that ran on water. Days later, he was dead—and his invention disappeared. But Meyer wasn’t the only one. There’s a federal law, still active today, that allows the U.S. government to classify and bury private inventions deemed a “threat.” It’s called the Invention Secrecy Act—and it’s already been used over 6,000 times.
From Nikola Tesla’s wireless energy to Townsend Brown’s anti-gravity tech to Joseph Papp’s engine that ran on noble gases, history is littered with breakthrough inventors who vanished into obscurity... and whose technologies never made it to the public.
This episode uncovers the case studies, the hidden power of secrecy orders, and the chilling question: What else have they buried?
Note to those who’d take to snorting and/or binging on fermented Stevia:
“The experiments were conducted on cancer cells grown in laboratory dishes—not in living organisms.”
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