Posted on 06/08/2023 11:45:41 AM PDT by Red Badger
Hair Growth
Northwestern Medicine scientists found that the stiffness of aging hair follicle stem cells hinders hair growth. They discovered that softening these cells using a tiny RNA, miR-205, stimulates hair growth in mice. Future experiments will test whether topically delivered miR-205 can promote hair growth potentially in humans.
Softening stiff hair follicle stem cells with a microRNA regrows hair.
Regulating cell mechanics stimulates hair growth in mice
Next step will be testing if delivering microRNA via nanoparticles grows hair Potential for human hair growth
Just as people’s joints can get stiff as they age and make it harder for them to move around, hair follicle stem cells also get stiff, making it harder for them to grow hair, reports a new Northwestern Medicine study.
But if the hair follicle’s stem cells are softened, they are more likely to produce hair, the scientists found.
Northwestern scientists discovered how to soften up those stem cells to enable them to grow hair again. In a study in mice published recently in the journal PNAS, the investigators report that they can soften the stem cells by boosting the production of a tiny RNA, miR-205, that relaxes the hardness of the cells. When scientists genetically manipulated the stem cells to produce more miR-205, it promoted hair growth in young and old mice.
“They started to grow hair in 10 days,” said corresponding author Rui Yi, the Paul E. Steiner Research Professor of Pathology and professor of dermatology at Northwestern University Feinberg School of Medicine. “These are not new stem cells being generated. We are stimulating the existing stem cells to grow hair. A lot of times we still have stem cells, but they may not be able to generate the hair.
“Our study demonstrates the possibility of stimulating hair growth by regulating cell mechanics. Because of the potential to deliver microRNA by nanoparticles directly into the skin, next we will test whether topically delivered miR-205 can stimulate hair growth first in mice. If successful, we will design experiments to test whether this microRNA can promote hair growth potentially in humans.”
This study was conducted in genetically engineered mouse models. The scientists used advanced microscopy tools, including atomic force microscopy, to measure the stiffness and two-photon microscopy to monitor cell behaviors in live animals.
Reference:
“MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells” by Jingjing Wang, Yuheng Fu, Wenmao Huang, Ritusree Biswas, Avinanda Banerjee, Joshua A. Broussard, Zhihai Zhao, Dongmei Wang, Glen Bjerke, Srikala Raghavan, Jie Yan, Kathleen J. Green and Rui Yi, 22 May 2023, Proceedings of the National Academy of Sciences.
DOI: 10.1073/pnas.2220635120
Other Northwestern authors include Jingjing Wang, Yuheng Fu, and Kathleen Green.
This study was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases grants AR066703, AR071435, AR043380, AR041836, and P30AR075049 of the National Institutes of Health.
Have to admit, at (this November) 90, my hair is thinning a little...
Mostly due to the Nation’s descent into the tyranny of communism...
Testing the rats will not do me any good...🙄
Someone is about to make a lot of $$$!
“The years passed, mankind became stupider at a frightening rate. Some had high hopes the genetic engineering would correct this trend in evolution, but sadly the greatest minds and resources where focused on conquering hair loss and prolonging erections.” - Idiocracy
If I want hair I’ll buy a wig!..........
Prescient!.............
Scientists finally doing something useful.
No kidding. Incontrovertible evidence!
It’ll be banned except for bald MtF trannies
The spike proteins grow out of the top of your head.
My husband has always had very thick, beautiful hair that grows rapidly. About 10 years ago he started saving it off and now looks much like the guy in the first parts of the clip.
He just didn’t want to deal with it anymore, and will probably never go back. Even as short as it is now, it’s amazing how much he shaves off every few weeks.
First there was Rogaine. Then came Propecia. If the stuff really worked you wouldn’t see any bald men out there-it’s not cheap.
If it worked they could name their price.
I think they make a Rogaine for women too, and when I’ve seen it, it seemed very expensive.
LOL! He’s cute.
(He looks like some kind of dusting or cleaning tool I’ve had...)
LOL, you forgot “Uncontrollable greasy discharge”!!!
Yeah at some point hair is just more trouble than it’s worth.
Well, I think losing it can be very difficult for some people.
Women often go through a thinning of their hair after menopause, but it usually isn’t as drastic as it is for men who go actually bald.
On the other hand, some men actually look very handsome when they are balding. I think the Prince of Wales looks very distinguished. (His younger brother looks like a medieval tonsured monk, though...)
some look distinguished, some look handsome, and some are just very macho looking.
I’m sure you fit in there somewhere :-)
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