Posted on 06/08/2023 11:45:41 AM PDT by Red Badger
Hair Growth
Northwestern Medicine scientists found that the stiffness of aging hair follicle stem cells hinders hair growth. They discovered that softening these cells using a tiny RNA, miR-205, stimulates hair growth in mice. Future experiments will test whether topically delivered miR-205 can promote hair growth potentially in humans.
Softening stiff hair follicle stem cells with a microRNA regrows hair.
Regulating cell mechanics stimulates hair growth in mice
Next step will be testing if delivering microRNA via nanoparticles grows hair Potential for human hair growth
Just as people’s joints can get stiff as they age and make it harder for them to move around, hair follicle stem cells also get stiff, making it harder for them to grow hair, reports a new Northwestern Medicine study.
But if the hair follicle’s stem cells are softened, they are more likely to produce hair, the scientists found.
Northwestern scientists discovered how to soften up those stem cells to enable them to grow hair again. In a study in mice published recently in the journal PNAS, the investigators report that they can soften the stem cells by boosting the production of a tiny RNA, miR-205, that relaxes the hardness of the cells. When scientists genetically manipulated the stem cells to produce more miR-205, it promoted hair growth in young and old mice.
“They started to grow hair in 10 days,” said corresponding author Rui Yi, the Paul E. Steiner Research Professor of Pathology and professor of dermatology at Northwestern University Feinberg School of Medicine. “These are not new stem cells being generated. We are stimulating the existing stem cells to grow hair. A lot of times we still have stem cells, but they may not be able to generate the hair.
“Our study demonstrates the possibility of stimulating hair growth by regulating cell mechanics. Because of the potential to deliver microRNA by nanoparticles directly into the skin, next we will test whether topically delivered miR-205 can stimulate hair growth first in mice. If successful, we will design experiments to test whether this microRNA can promote hair growth potentially in humans.”
This study was conducted in genetically engineered mouse models. The scientists used advanced microscopy tools, including atomic force microscopy, to measure the stiffness and two-photon microscopy to monitor cell behaviors in live animals.
Reference:
“MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells” by Jingjing Wang, Yuheng Fu, Wenmao Huang, Ritusree Biswas, Avinanda Banerjee, Joshua A. Broussard, Zhihai Zhao, Dongmei Wang, Glen Bjerke, Srikala Raghavan, Jie Yan, Kathleen J. Green and Rui Yi, 22 May 2023, Proceedings of the National Academy of Sciences.
DOI: 10.1073/pnas.2220635120
Other Northwestern authors include Jingjing Wang, Yuheng Fu, and Kathleen Green.
This study was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases grants AR066703, AR071435, AR043380, AR041836, and P30AR075049 of the National Institutes of Health.
I like my natural baldness. The last thing I want is gene therapy to fix something I don’t consider broken.
Let me guess, in 5 years.........
Nice. Over time I suspect they will figure this out and help out a lot of people.
Side effects include gynecomastia, sporadic moodiness and chocolate cravings.
Bttt
I’ll take it!
Nice time lapse of a person’s hair growing back after shaving it.
microRNA....mRNA?? There is/was discussion that Big Government wants to make all vaccines into some kind of gene therapy. I used to trust the historic USA medical and vaccines industry. When we were very, very young we were given sugar cubes with vaccine. The USA eliminated some very bad diseases with real science. Today, I have very little trust. They recommend I get the pneumonia vaccine. Before the Plandemic, I would not have hesitated.
Probably also causes strokes.
But at least you’ll die with a full head of hair......................
I used to understand mRnA as messenger RNA which is form or class of RNA that has the function of carrying proteins from one location to another. Maybe the writer of this article doesn’t know that there is no such thing as microRNA. RNA is already smaller than micro, it’s even smaller than nano.
As long as it doesn’t lead to heart attacks I’m all in.
Or institute the mark of the beast. Either way.
cha-cha-cha-chipet
He looks like he has a porcupine on his head!...........
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